LOCUS       FN545816               22370 bp    DNA     linear   BCT 27-FEB-2015
DEFINITION  Clostridium difficile R20291 complete genome.
ACCESSION   FN545816
VERSION     FN545816.1
KEYWORDS    .
SOURCE      Clostridioides difficile R20291 (Clostridium difficile R20291)
  ORGANISM  Clostridioides difficile R20291
            Bacteria; Firmicutes; Clostridia; Clostridiales;
            Peptostreptococcaceae; Clostridioides.
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-32bee55(changed)
            Run date     :: 2021-04-09 12:09:52
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3742177
            Orig. end    :: 3764547
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22370
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[3752177:3754547](-)"
                     /cutoff="2000"
                     /detection_rule="((PFL_proline or cds(PFL-like and
                     Gly_radical)) and Radical_SAM and P5CR_dimer and
                     F420_oxidored)"
                     /neighbourhood="10000"
                     /product="Hydroxy-L-proline2proline"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(10001..12370)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_proline or cds(PFL-like and
                     Gly_radical)) and Radical_SAM and P5CR_dimer and
                     F420_oxidored)"
                     /neighbourhood="10000"
                     /product="Hydroxy-L-proline2proline"
                     /protocluster_number="1"
     cand_cluster    1..22370
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((PFL_proline or cds(PFL-like and
                     Gly_radical)) and Radical_SAM and P5CR_dimer and
                     F420_oxidored)"
                     /kind="single"
                     /product="Hydroxy-L-proline2proline"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..22370
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Hydroxy-L-proline2proline"
                     /region_number="17"
                     /rules="((PFL_proline or cds(PFL-like and Gly_radical)) and
                     Radical_SAM and P5CR_dimer and F420_oxidored)"
                     /tool="gutsmash"
     gene            complement(1743..2798)
                     /locus_tag="CDR20291_3136"
     CDS             complement(1743..2798)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3136"
                     /db_xref="EnsemblGenomes-Tr:CBE06984"
                     /db_xref="GOA:C9YRB8"
                     /db_xref="InterPro:IPR001347"
                     /db_xref="InterPro:IPR005855"
                     /db_xref="UniProtKB/TrEMBL:C9YRB8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CDR20291_3136"
                     /product="putative phosphosugar isomerase"
                     /protein_id="CBE06984.1"
                     /sec_met_domain="SIS (E-value: 8.1e-11, bitscore: 39.6,
                     seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIQDYMLETPVRMREIISNADSLFNEVKRANLKKIIITGSGTSY
                     HSGVQVQPYLQNLLDIDVVKMYPFMITEDTFKFDNENTLVVGVSQGGSSYSTYNAMKLA
                     EDKGCKIASMAGCKNALIDEISDYILTVNCGEEKSGAKTKGYYCTKLNLMLLGLQIARE
                     KGTISSEKYNEEINKILDAINRFEAVYKLSKQWIERNKEKLVNSKEIRIIGHSDIYGDT
                     LEAALKLLETMRIPVTGYEFEEFIHGIYNAINSDSTIFILDTGKEPRVTKMIDVLSGWT
                     ENVFAIGRDVTENDKNLKIDITDNPYYQTFNFIVPIQLICGEIPTLRGVDPSVPKDTRF
                     HMKLGSKKLNK"
     gene            complement(2846..3613)
                     /locus_tag="CDR20291_3137"
     CDS             complement(2846..3613)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3137"
                     /db_xref="EnsemblGenomes-Tr:CBE06986"
                     /db_xref="GOA:C9YRB9"
                     /db_xref="InterPro:IPR004704"
                     /db_xref="UniProtKB/TrEMBL:C9YRB9"
                     /locus_tag="CDR20291_3137"
                     /product="PTS system, IId component"
                     /protein_id="CBE06986.1"
                     /transl_table=11
                     /translation="MFWRSFALQGAFNYERMQNLGYCYSMLPAIKKLYNKKENQAKAIE
                     RHLEIFNTTTVVVPAILGITAAMEEENANNPEFDESSISAVKTALMGPLAGIGDSLFWG
                     TFRIIAAGVGVSLAKEGNIFGPLLFLLLYNIPAFALRIFGLKYGYKVGVNSLERIQREG
                     LMEKIMSMATTVGLFVVGGMVATMLSITTPLKFNLNGAEVILQDILDKIIPNMLPLTFA
                     FLIYYMLKRKVSVTKLTIGTIVTGIALHAIGLL"
     gene            complement(3639..4430)
                     /locus_tag="CDR20291_3138"
     CDS             complement(3639..4430)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3138"
                     /db_xref="EnsemblGenomes-Tr:CBE06987"
                     /db_xref="GOA:C9YRC0"
                     /db_xref="InterPro:IPR004700"
                     /db_xref="UniProtKB/TrEMBL:C9YRC0"
                     /locus_tag="CDR20291_3138"
                     /product="PTS system, IIc component"
                     /protein_id="CBE06987.1"
                     /transl_table=11
                     /translation="MLVQATMLAIIAGVGILDGRIFGQSMFDRPIVTGMLVGLVLGDIK
                     SGIMIGAQLELIWMGIAGIGAATPPDVVTGGVLGTAFAILSGNGAEVALAVAVPVAVLA
                     QSLGVLVRIINSYFSQKAVFYAKQADFKKVTIMMWLPVILFFLSTSVPTFLAIMIGADK
                     VTTLINAIPKVILDGLGVAGTLLPAVGFALLMDMLISKKMSVFFFIGFLLASYGGLDIT
                     AIALFGVCVAFVLNFYINNKENNQNPQLAMNTLTEGEIDFE"
     gene            complement(4470..4892)
                     /locus_tag="CDR20291_3139"
     CDS             complement(4470..4892)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3139"
                     /db_xref="EnsemblGenomes-Tr:CBE06989"
                     /db_xref="GOA:C9YRC1"
                     /db_xref="InterPro:IPR004701"
                     /db_xref="UniProtKB/TrEMBL:C9YRC1"
                     /locus_tag="CDR20291_3139"
                     /product="PTS system, IIa component"
                     /protein_id="CBE06989.1"
                     /transl_table=11
                     /translation="MKKFLIATHGELSRELVDTSKLIIGSLANIEYFCMTKDKSADDAE
                     KEIRSILSNNKDSEEFVVLTDVFGGSVANICTNLLLQGFKFELLTGVNLPMLLSIFLLV
                     EEDTKLIVKSGLEEAKNGIVYVNELLENRNKIKNVM"
     gene            complement(4908..5387)
                     /locus_tag="CDR20291_3140"
     CDS             complement(4908..5387)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3140"
                     /db_xref="EnsemblGenomes-Tr:CBE06991"
                     /db_xref="GOA:C9YRC2"
                     /db_xref="InterPro:IPR004720"
                     /db_xref="UniProtKB/TrEMBL:C9YRC2"
                     /locus_tag="CDR20291_3140"
                     /product="PTS system, IIb component"
                     /protein_id="CBE06991.1"
                     /transl_table=11
                     /translation="MVSLMRIDDRLIHGQVAYGWATSLGINVILVANDEAKNDQMKAMS
                     LNLAKPSNVTLYIRGVEESGEIVEKFASSKKSNVLVLVKNTRDALVVAKNSGGVLKEIN
                     VGGLRYEEGKKKLTDLVAVDDDDINNFKEIGDLGIDIELRMLPRDKKKQLSDLIK"
     gene            complement(5519..8275)
                     /locus_tag="CDR20291_3141"
     CDS             complement(5519..8275)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3141"
                     /db_xref="EnsemblGenomes-Tr:CBE06993"
                     /db_xref="GOA:C9YRC3"
                     /db_xref="InterPro:IPR002078"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR004701"
                     /db_xref="InterPro:IPR011608"
                     /db_xref="InterPro:IPR025662"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:C9YRC3"
                     /locus_tag="CDR20291_3141"
                     /product="putative transcription antiterminator"
                     /protein_id="CBE06993.1"
                     /transl_table=11
                     /translation="MRDEILSFVNECVLFNNFDELKKESGIITEDIVKKFNLSRTQSSR
                     LLNDLVKSDNLIKINSRPVIFLPKNKINDVVGPTKKSIYENLDELKNECKLLKQETVFN
                     SIIGYDNSLKEVIEQIKTAVLYPNGGLTIMLTGESGVGKTFLAKIIYKYSVSSNVLEKN
                     SPYNVLNCAQYYNNLELLSSLLFGHVKGAYTGANESRAGLIEQSDGGVLFLDEVHRLNS
                     EGQEKLFTFMDTGTFSRIGENGVIRKARVRLIFATTESLSKFLQTFLRRIPINIYVPNI
                     EERGTIEKRKIVEHFIYEESKVLGLPIEITQITLNTILKIKFKGNIGECKNVIKYACGR
                     AYAKNQRRNGNIFVTLQDLPRNLYIENVDIFQFQSGKSKSIIFSPKQFSIEMSNGRNKR
                     NIIYQSFIKCLDYFDRLEKNEITKEIFSKKSSNLMIRLMDNLVFSNNDENNNVLMELII
                     SIMQDIFRNLEVNNNIKYDGNNVLAFSSYLYLKDESYQLSDEYKALESKLLIYLKKESY
                     KEYSIISKISTLITNRLDMYLNNVDTIIMIIFIKSTIIRMKFNQVNATIIAHGYATASS
                     MANVCNRMLGKNIFTAIDMPIDATIADVSKQMSRYLEGDRIKNGLIVLFDMGSLNLIYE
                     DLKNKINGPMLFIDQISTISALEVGNLLMQGKNIEQIAEIMDEETKPNIQLYYPQKNKE
                     YAIISSCFTGIGTAIKIQHLLSESLIGIVDVKIIPYDYDSLVSMGDKEPVFEMYDVMAI
                     VGTANPNVNGVDFILLEDIISGKGEDDVFRIFSRVVENEKIKNINDSIVKNFSLIRVID
                     SLTILDSKKIIERIEEGINAIENIQKKKLPNDKKISLYVHLSCMIERLVRQTEIEEYTD
                     MDLLIKNHHSEVKLIKNAFSVLEKSYSVQIPISEIGYIYNIIYGLPQ"
     gene            complement(8873..9676)
                     /gene="proC2"
                     /locus_tag="CDR20291_3142"
     CDS             complement(8873..9676)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3142"
                     /db_xref="EnsemblGenomes-Tr:CBE06995"
                     /db_xref="GOA:C9YRC4"
                     /db_xref="InterPro:IPR000304"
                     /db_xref="InterPro:IPR008927"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR028939"
                     /db_xref="InterPro:IPR029036"
                     /db_xref="UniProtKB/TrEMBL:C9YRC4"
                     /gene="proC2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) P5CR_dimer"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CDR20291_3142"
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="CBE06995.1"
                     /sec_met_domain="NAD_binding_2 (E-value: 2.3e-07, bitscore:
                     28.8, seeds: 140, tool: rule-based-clusters)"
                     /sec_met_domain="F420_oxidored (E-value: 2.4e-19, bitscore:
                     67.4, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="P5CR_dimer (E-value: 8.8e-42, bitscore:
                     139.4, seeds: 951, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLGFIGSGNMGSAMIGGIVQSGLVKAEDITVSDLSQVALDKVK
                     EEFGINTTTDSKVAVTNSDVVIVALKPNICEKALTPLKELIDANKIIVSIAAGKTIESL
                     ESFIGSDKKIVRVMPNTPALVGEGMSALCKNSNVTDEELNMIKALFESFGEAEIVSEYL
                     MDTVTGISGSSPAYVFMFIEAMADAAVLAGMPRQQAYKFASQAVMGSAKMVLETGKHPG
                     ELKDMVCSPAGTTIEAVKVLEEEGFRAAVIKSIVACIDKSKDMSK"
     gene            complement(10001..12370)
                     /gene="pflD"
                     /locus_tag="CDR20291_3143"
     CDS             complement(10001..12370)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3143"
                     /db_xref="EnsemblGenomes-Tr:CBE06997"
                     /db_xref="GOA:C9YRC5"
                     /db_xref="InterPro:IPR001150"
                     /db_xref="InterPro:IPR004184"
                     /db_xref="UniProtKB/TrEMBL:C9YRC5"
                     /gene="pflD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Hydroxy-L-proline2proline: PFL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Hydroxy-L-proline2proline: Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_3143"
                     /product="putative formate acetyltransferase"
                     /protein_id="CBE06997.1"
                     /sec_met_domain="Gly_radical (E-value: 9.8e-33, bitscore:
                     110.6, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL-like (E-value: 2.4e-228, bitscore:
                     757.7, seeds: 123, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARGTFERTKKLREESINAEPHISIERAVLMTEAYKKYEGSVEIP
                     VLRALSFKHYIENRTLSINDGELIVGEKGDSPNGAPTYPEICCHTMEDLEVMHNRDIIN
                     FSVSEEARKIHKEEIIPFWKKRQTRDKIINAMTPEWLAAYEAGMFTEFMEQRAPGHTVC
                     GDTIYKKGFLDLKKDIEARLKELDFLNDLDAYNKKADLEAMAIACDAMVILGKRYAEKA
                     RQMAEEETDEAKKKDLLLIAETCDVVPAHKPETYHQAIQMYWFVHIGVTTELNIWDAFT
                     PGRLDQHLNPFYERDVENGILDRDRAQELLECLWVKFNNQPAPPKVGITLKESSTYTDF
                     ANINTGGINPDGQDGVNEVSYIILDVMDEMKLIQPSSNVQISKKTPQKFLKRACEISRK
                     GWGQPAFYNTEAIVQELMEAGKTIEDARLGGTSGCVETGCFGKEAYVLTGYMNIPKILE
                     LTLNNGYDPISKKQIGIETGDPRNFQSYEELFEAFKKQLHYMIDIKIEGNAVIENICAK
                     HMPCPLMSTIVDDCIEKGKDYQRGGARYNTRYIQGVGIGTITDSLTAIKYNVFDKKKFD
                     MDTLLKALDANFEGYEAILNLVSNKTPKYGNDDDYADEIMQEIFNAYYNEVTGRLTVCG
                     GEYRVDMLPTTCHIYFGEIMGASPNGRLCAKPVSEGISPEKGGDTNGPTAVIKSCAKMD
                     HIKTGGTLLNQRFAPSVVQGEKGLDNMANLVRAYFNMDGHHIQFNVFDKNVLLEAQKNP
                     KDYKDLIVRVAGYSDHFNNLSRTLQDEIIGRTEQTF"
     gene            complement(12375..13283)
                     /gene="pflE"
                     /locus_tag="CDR20291_3144"
     CDS             complement(12375..13283)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3144"
                     /db_xref="EnsemblGenomes-Tr:CBE06998"
                     /db_xref="GOA:C9YRC6"
                     /db_xref="InterPro:IPR001989"
                     /db_xref="InterPro:IPR007197"
                     /db_xref="InterPro:IPR012839"
                     /db_xref="InterPro:IPR017896"
                     /db_xref="InterPro:IPR017900"
                     /db_xref="UniProtKB/TrEMBL:C9YRC6"
                     /gene="pflE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CDR20291_3144"
                     /product="putative pyruvate formate-lyase 3 activating
                     enzyme"
                     /protein_id="CBE06998.1"
                     /sec_met_domain="Radical_SAM (E-value: 3.4e-19, bitscore:
                     67.5, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPLVINLQKCSIHDGPGIRSTVFFKGCPLECVWCHNPESQTYTK
                     QVLYNEERCSKCEACINICPHKAIYKGETKICLDQDKCEFCETCLDYCVNNAREIVGQE
                     YSVRDLVKEIEKDRIFYEESGGGVTLSGGEVMAQDMDFICGVINMCKSKGIHVAIDTCG
                     YAKSENYERVAKCADLFLYDIKLIDEDKHIKFTGKSNDLILKNVKILSELGVNINIRIP
                     LIVGVNVDDENLEVKKMIEFLKPLNIQAVSLLPYHNIGKHKYDKIYKKYEGEELQRPSE
                     EKLEEIKRLFEASNFNTKIGG"
     gene            complement(13628..14707)
                     /locus_tag="CDR20291_3145"
     CDS             complement(13628..14707)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3145"
                     /db_xref="EnsemblGenomes-Tr:CBE07000"
                     /db_xref="GOA:C9YRC7"
                     /db_xref="InterPro:IPR001254"
                     /db_xref="InterPro:IPR001478"
                     /db_xref="InterPro:IPR001940"
                     /db_xref="InterPro:IPR009003"
                     /db_xref="UniProtKB/TrEMBL:C9YRC7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trypsin_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CDR20291_3145"
                     /product="probable protease"
                     /protein_id="CBE07000.1"
                     /sec_met_domain="Trypsin_2 (E-value: 2.6e-34, bitscore:
                     117.0, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRRKKGISLVILVAIISSILSSFLTIILVKDNLVSKSTGSSTPI
                     VVNDDGKSQNIYQAVAEKATPSVVGITTTSVDTSNMFAIPTETQGVGTGIIVDSNGYIL
                     TNSHVISDGQATSVNVLFNDGSTTSGKVVWFDQQLDLAIVKVDKTGLTPAEFADSDKVK
                     VGDISIAIGNPLGLDFQKTVTQGIISGLDRTIQTEKTNMTGLLQTDASINAGNSGGPLL
                     NQKGQVIGINTAKASQAEGLGFAIPINTAKSIVEEVIKNGKYEKVTLGIKGTDVSNYEA
                     ATGTKLSTDKGVYVAEVISGSSAEKAGVKVGDIITKVGDTDITGMNDLNKKLYTFSKGA
                     STKITVNRGGKAVTINVNF"
     gene            complement(14863..16212)
                     /gene="pgi"
                     /locus_tag="CDR20291_3146"
     CDS             complement(14863..16212)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3146"
                     /db_xref="EnsemblGenomes-Tr:CBE07002"
                     /db_xref="GOA:C9YRC8"
                     /db_xref="InterPro:IPR001672"
                     /db_xref="InterPro:IPR018189"
                     /db_xref="UniProtKB/TrEMBL:C9YRC8"
                     /gene="pgi"
                     /locus_tag="CDR20291_3146"
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="CBE07002.1"
                     /transl_table=11
                     /translation="MGKINFDYSKATEFFCQNEIDVMQPYVDVAHDMLHNKTGLGNTFL
                     GWIDLPKNYDKEEFDRIKKSAEKIKSDSDVLLVIGIGGSYLGSRAAIDMVSHSFRNGLK
                     KEQRKAPEVYFVGHNISSTYIMDLLDIIEGKDISVNVISKSGTTTEPALAFRIFKDYLE
                     KKYGKEEARKRIYATTDASKGALRQLATEEGYETFVIPDDVGGRFSVLTAVGLLPIAAA
                     GLDIDAMMKGANDAREAFQNPDLKSNDSYRYAVARTILHRKGKDVELLVNYEPQLHYVS
                     EWWKQLYGESEGKENKGLFPASVDFSTDLHSMGQYIQDGKRLLFETVLNVENCKRNITI
                     SSEEVDLDGLNYLAGKTVDFVNHKAFEGTLLAHTDGKVPNLVINIPQLDEYNFGYLVYF
                     FEKACGISGYLLGVNPFDQPGVEAYKKNMFALLGKPGYEKEKEELEKRLK"
     gene            complement(16477..18084)
                     /locus_tag="CDR20291_3147"
     CDS             complement(16477..18084)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3147"
                     /db_xref="EnsemblGenomes-Tr:CBE07004"
                     /db_xref="GOA:C9YRC9"
                     /db_xref="InterPro:IPR003841"
                     /db_xref="InterPro:IPR004633"
                     /db_xref="InterPro:IPR026022"
                     /db_xref="UniProtKB/TrEMBL:C9YRC9"
                     /locus_tag="CDR20291_3147"
                     /product="putative sodium-dependent phosphate transporter"
                     /protein_id="CBE07004.1"
                     /transl_table=11
                     /translation="MGGLGLFLYGMNLMGEGLQKSAGTKLKKIIKLLTSNLFMGVLVGT
                     GVTAVIQSSSATTVMVVGFVNAGIMTLKQAIGVIMGANIGTTVTAQLVSFDLTGMAPVA
                     LGVGIILYLFGNKPRIKNIAEILIGFGILFTGMDFMKMAVEPLRDYQGFTDLLVTFGRY
                     PLLGLLLGFGITAIIQSSSASMGMLVALAAEGLVPLSAALPILYGQNIGTCVTSLLSSI
                     GANKNARRAAMMHLIFNVLGTVIFLIFLNKPVVSMVTSWDPSNVARQIANTHTLFNIIS
                     VLILLPFTNLIIKLAIKLVPDRAGDIDEDETKTIKYIDDRMIETPSIALANTIKEALRM
                     GEKAKESLNASMEALVEHSTEKIAKTYRRERLINDLQKAILNYLLKLSKAPLDDDSREV
                     VDTLFNTVNDIERIGDHAKNIAELSQVAIDSNISFSEEGQSELDVMYNRVVSAYTYALE
                     SMRTDNVDLACKVIKIEEQVDIMEKSCRANHMYRLNNNLCSIENGVIYLDVISNLERIS
                     DHAVNIAQQVIAKRLGND"
     gene            complement(18229..19935)
                     /locus_tag="CDR20291_3148"
     CDS             complement(18229..19935)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3148"
                     /db_xref="EnsemblGenomes-Tr:CBE07005"
                     /db_xref="GOA:C9YRD0"
                     /db_xref="InterPro:IPR006076"
                     /db_xref="InterPro:IPR028348"
                     /db_xref="UniProtKB/TrEMBL:C9YRD0"
                     /locus_tag="CDR20291_3148"
                     /product="conserved hypothetical protein"
                     /protein_id="CBE07005.1"
                     /transl_table=11
                     /translation="MGRKSSKREYRSYICRKLGITLAFLYYNLREENNMLRVSNVKLGI
                     DKDISLLKDVVLKKLKIKEKNLVKYSIYKESIDARKKGKMEFVYSVDVEVKDENKILNS
                     KIKDVTKIKEIRYINVPVGDKKLKNNPLVIGSGPAGLFAGLLLAQMGYEPIILERGLDV
                     DSRTKDISDFWTTRKLKNNSNVQFGEGGAGTFSDGKLTTRIKDIRCRKVLEELVQFGAP
                     DEILYSHKPHVGTDILKNVVKNIRNEIISLGGQVRFNSKVTDIVVSNDSIQSVIINDTE
                     KIDTDTIILAVGHSARDTYEMLYSRGIKIVQKPFAIGARVEHPQDLINKAQYKDFYNHP
                     RLGAADYRLIEHVSNGRTAYTFCMCPGGSVIASASNDFEIVTNGMSEHARDKINANSAF
                     LVNVTPEDFKSDNPLAGVHFQQKYEKLAFELGGKNYNAPVQLVGDFINNKTSLNLGSVE
                     PSYRPGYTLTNLSECLPSFVTETMREAFISLDKKLNGFAMYDAVLTGVETRSSSPIRIV
                     RDENTLESVSIKNLYPCGEGAGYAGGIVTAAVDGIKCAEKIIQKYTNNTKI"
     gene            complement(19881..20198)
                     /locus_tag="CDR20291_3149"
     CDS             complement(19881..20198)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3149"
                     /db_xref="EnsemblGenomes-Tr:CBE07007"
                     /db_xref="UniProtKB/TrEMBL:C9YRD1"
                     /locus_tag="CDR20291_3149"
                     /product="hypothetical protein"
                     /protein_id="CBE07007.1"
                     /transl_table=11
                     /translation="MDYIGIENITPYENTYEFSVYEYDDEITLGSEKLYVCELRVVLIK
                     VNSLYVERLHKSVEAMVLVKNLKKDLDKTLVVNKIKNFVLDEIWVENLVKENIEVIFVE
                     S"
     gene            complement(20203..20568)
                     /locus_tag="CDR20291_3150"
     CDS             complement(20203..20568)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3150"
                     /db_xref="EnsemblGenomes-Tr:CBE07009"
                     /db_xref="UniProtKB/TrEMBL:C9YRD2"
                     /locus_tag="CDR20291_3150"
                     /product="hypothetical protein"
                     /protein_id="CBE07009.1"
                     /transl_table=11
                     /translation="MSLSLGNAIAVSTNFIKSNPAVPVYNGEEIYAVIYHIEIGYNNGV
                     SPDTKQYIIIDYKEFDLSMDKKNELINVAKEYCKSKGIVENENLEINLLDNEEAENFLE
                     KVFNNMKVIRGLITKKG"
     gene            complement(20649..21698)
                     /locus_tag="CDR20291_3151"
     CDS             complement(20649..21698)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_3151"
                     /db_xref="EnsemblGenomes-Tr:CBE07011"
                     /db_xref="GOA:C9YRD3"
                     /db_xref="InterPro:IPR004027"
                     /db_xref="InterPro:IPR007889"
                     /db_xref="InterPro:IPR013763"
                     /db_xref="UniProtKB/TrEMBL:C9YRD3"
                     /locus_tag="CDR20291_3151"
                     /product="putative protein translocase"
                     /protein_id="CBE07011.1"
                     /transl_table=11
                     /translation="MEVILLGRNELCPCGSGKKYKKCCLNKDIVSERACRKTELSQKQY
                     TDLYSKLYDYSRQDKFKEECEKAKEMFYIMQNDSVNEKFERFFNTYLIQDHIMENKKVM
                     TVGFLEENGANLSQSEVSILKSMFESYVSIYEVKEVSAGKIVLKDCLSGNELCTEDVKL
                     LRSFKIGSCMIARIVDIEGTNILIDITISISNEVKDIILKDIMNLFNQYQDVYKDMKSF
                     LIYHTHILYKYIQQLLDPSIAEYLKRERDKNDTKVNSENELAEEECKVLDTLKENVEKE
                     NIDACIEFWNEYKKNHENIKGAENGWAAAVEYYVKKEAGQPITQVQISKKYDISSSTLG
                     KRYKDLKIS"
ORIGIN
        1 atatagatgc caaaaaatta agtgaagaac ttggagtaat tgttgttcca attatagcaa
       61 aaaagaaaaa tggtgttgat aggatagaag aagagattaa gggagctacg caaaaagctt
      121 ttatatatca gaaaaacttt ggaagtgaaa cagaaacata taaaaaatta gaatccattt
      181 tatcgagatg tacaaaaact acatatacac aaaagaaatc tatcagtgat aagatagaca
      241 atatagtctt gaatcctata ttagcatatc cgatatttat tggtgtattg ttcctcttat
      301 ttaaatttac ctttgactgg gtcggaggac cactacaaga gggatttgct agtcttatag
      361 aggcttatat ttctgcacct gttagtgata tgttatctaa ctctagccca tggtttaaat
      421 cacttatagt tgatggaata attggaggtg ttggtggtac tttaccattc ttccctttaa
      481 tatttacatt attctttggt atatcgttgt ttgaagatag tggatacatg tcaagaacag
      541 catttttaat ggataaagtt atgagaaagg ttggtctatc tggtaaagct tttataccta
      601 tagttatggg tatgggatgt tcttctccag ctataatggc aactagaaca ttggaaagcg
      661 aaaaagatag aagagttaca gctcttattg caccacttat gacttgtgga gcaaagctac
      721 ctatatatgc actatttgta gctatattct ttccacataa tgctgcttta gtaactacgt
      781 cactgtattt ggtgggtata gttatggcaa ttgtagttgc attattctta aataaaacag
      841 cctttaaaac agaggctgaa ccatttatat tagaattacc agaatataga atccctacta
      901 tagatgcact tattaaaaat acttggaata aatcaaaagg tttcttgata agagttgtta
      961 ctgtcatgtt tgcaatgtca gtcgtaattt ggggactttc ttcattcaat gtttttggat
     1021 atacagaaga tataaatgta agcttcttgg ctactctagg tcatattata tctcctatat
     1081 tcaaacctct tggttttgat gattggagaa cttcagttgc tattttaagt ggtcttggag
     1141 caaaagaaat cgtagtaaac tctttaaata tactatatgg taatctaact gttgtcttac
     1201 caacaatatt taatggagtt actgcatata cattcttgat atttactgct ttatatactc
     1261 catgtatagc tgcacttgca actatgaaaa aagaatatgg caataaaatg atgtttacat
     1321 catttgcata tcaatttata ctagcatgga taatggcttt tatagttaaa agcataggtg
     1381 gagtactatt tatgggtaat tcaataatgg aagctttgat aggtggaata attatagtcc
     1441 ttgcactctt tattctgttt aataaattca agtctacaaa aaacggaaat gtctgtagtg
     1501 gatgttctat ttgctctgga tgtccaagtg ctaattcttg ctcaagtaag gaagacagca
     1561 ataaaaaaag taatacacac taatatataa atattttagt ttaaaataag ataaaagtgg
     1621 gtgtctcaaa attaactttt tagttcatga ggcactcttt tttatataaa atcaaatata
     1681 ttttcatcat ttcaacagtc aaaaagaggc ttatctctat tttgagacaa cctctttttt
     1741 tgttacttat tcagtttctt gctacctaac ttcatgtgga acctagtatc ttttggaaca
     1801 cttgggtcta cgcctcttaa tgtaggtatt tccccacata ttagttgtat aggtactata
     1861 aaattaaatg tttgatagta aggattatct gtgatatcaa tctttaaatt tttatcattt
     1921 tctgtaacat ctctacctat agcaaataca ttttccgtcc aaccagaaag tacatcaatc
     1981 atcttagtta ctctaggttc ttttcctgta tctagtataa atatagtaga atcactattt
     2041 atagcattat atataccgtg tataaactct tcaaactcat acccagttac aggtattctc
     2101 attgtttcca ataattttaa tgctgcttct aatgtatctc catatatatc agagtgacct
     2161 attattctta tttctttaga attaactaac ttttctttgt ttctttcaat ccattgttta
     2221 gagagcttat acactgcttc aaatctatta attgcatcta atatcttatt tatttcctca
     2281 ttgtactttt cactagatat tgtacctttt tctctagcta tttgaagacc taataacatt
     2341 aagtttaact ttgtacaata atatcctttt gttttagctc cagatttttc ttcaccacaa
     2401 tttactgtta atatataatc agaaatctca tctattaaag cattcttaca acctgccata
     2461 gatgctattt tacaaccctt atcttcagct aacttcatag cgttgtatgt agaataacta
     2521 ctcccacctt gagatacacc tactactagg gtattttcat tatcaaactt gaatgtatct
     2581 tcagttatca taaatggata cattttcaca acatctatat ctaataaatt ttgtaaatat
     2641 ggttgcactt gcactcctga gtgatagcta gtacctgaac ctgttattat aatctttttt
     2701 agatttgctc tcttaacttc attaaataag ctatctgcat tagatataat ttctctcatt
     2761 ctaactggtg tttctaacat ataatcttgt attgtcattt tatacacctt ccttatctat
     2821 atattcaata aattataatt aatttctata acaaacctat agcatgtaaa gcgattcctg
     2881 ttactatagt gcctatagtt aattttgtta cacttacctt tctcttcaac atgtaatata
     2941 ttaaaaatgc aaaggttaaa ggtaacatat taggtattat tttatctagt atatcttgta
     3001 aaattacttc tgcaccattt aagttaaatt tcaaaggagt agttatactc aacatagttg
     3061 caaccattcc tcctacaacg aataaaccga cagttgtagc catagacatt atcttctcca
     3121 taagtccctc tctttgtatt ctttcaagag aatttacccc tactttataa ccatacttaa
     3181 gtccaaatat tctaagggca aatgctggta tattgtataa taataagaat aatagtggtc
     3241 caaagatatt gccttctttt gcaagtgata ctcctactcc tgctgctata atcctaaatg
     3301 ttccccagaa taatgaatca ccaattcctg caagaggtcc cataagagct gttttaacag
     3361 cactaattga actttcatca aattctggat tattagcatt ttcttcttcc atagctgctg
     3421 ttatacctaa tatagcagga actaccactg tcgttgtatt aaaaatctct aaatgccttt
     3481 ctattgcttt tgcttgattt tctttcttat tatatagctt ctttattgca ggtaacattg
     3541 aataacaata acctaagttt tgcattcttt cgtaattaaa tgcaccttga agagcaaatg
     3601 aacgccaaaa catacttctt aattcttttt ttgttaattt attcaaagtc aatctctcct
     3661 tccgttaaag tattcattgc taattgagga ttttgattat tttctttgtt attgatataa
     3721 aagtttagta caaatgctac acatactcca aataaagcta tagcagttat atctaatcca
     3781 ccataagatg ctaacaaaaa ccctataaag aaaaatacag acatcttttt tgaaatcaac
     3841 atatccataa gcaacgcaaa acctactgct ggcaacaatg ttcctgcaac acccaatccg
     3901 tctaatataa ctttaggtat tgcatttatc aatgttgtaa ctttatcagc accaatcata
     3961 attgctaaaa aggttggaac tgatgtactt aaaaagaata atattactgg caaccacatc
     4021 attatggtaa ctttcttaaa atcagcctgt ttagcataga aaactgcctt ttgagaaaag
     4081 tacgaattta ttattctaac taatactcca agagattgtg ctaatactgc tactggcact
     4141 gccactgcta aagcaacttc tgcaccatta cctgataata tagcaaaagc tgtacccaat
     4201 acacctcctg ttactacgtc tggaggagta gctgcaccta tccctgcaat tcccatccaa
     4261 attaattcaa gctgtgcacc aatcataatt cctgatttta tgtctcctaa aactaatcca
     4321 actaacatac ctgtaactat tggcctatca aacatagatt gaccaaatat acgcccatct
     4381 agtataccaa ctcctgctat aatagctaac atagtagctt gtactaacat attgaacctc
     4441 cattttaact tagtttaatt tacattaaat tacattacat ttttgatttt atttcgattt
     4501 tctaataact catttacata aacaattcca ttttttgctt cctctaagcc tgatttaact
     4561 attagttttg tatcctcctc aactaataag aatatagata aaagcattgg taaatttacg
     4621 cctgtcaaca attcaaattt gaacccttgc aaaagtaagt ttgtacatat atttgccaca
     4681 cttccaccaa acacatctgt taaaacaaca aattcttcac tatctttatt atttgataat
     4741 atacttctaa tttctttctc agcatcatct gctgatttat cttttgtcat acaaaaatac
     4801 tcaatattag ctaatgaacc aattattaat ttacttgtgt caacaagttc tctagacaat
     4861 tctccatgtg ttgcaattag aaattttttc attctctttc tcctaaatta ttttattaaa
     4921 tctgatagtt gtttcttttt gtctctaggt aacattctaa gttctatatc aattcctaaa
     4981 tcacctattt ctttaaagtt atttatatca tcatcatcaa cagcaactaa atctgtaagt
     5041 ttcttttttc cttcttcata tcttaaccct cctacattta tttcttttaa tactcctcct
     5101 gaatttttag ctacaactaa agcatctctg gtatttttta ctaacactaa tacattgctt
     5161 ttctttgaag aagcaaattt ttctactatt tctccagatt cctctacccc ccttatatat
     5221 aaagttacat tgctaggttt cgctaaattc agtgacatag ctttcatttg gtcatttttt
     5281 gcttcatcat ttgcaactag tattacattt atacctagtg atgttgccca tccatatgca
     5341 acctgaccat gtatcaatct gtcatcaatt ctcatcaaag ataccatttt ccccaaatcc
     5401 tccatcatac attaaaattt ttattgttta tactctcatt tatctataaa agcaaaaagt
     5461 atgccaaata ctggcatact attttaaatt tcatttactt attttgtaat cttgtatttt
     5521 actgtggtag accatagata atattataaa tatatcctat ctctgaaatt ggtatttgca
     5581 cactataact cttttctagc acactaaatg cattttttat tagttttact tcactatgat
     5641 ggtttttgat taacaaatcc atatcagtat actcttcaat ttcagtttgt ctaactaatc
     5701 tttcaatcat acaacttaaa tgaacatata aagaaatctt tttatcattt ggaagttttt
     5761 tcttttgaat attttctata gcattgattc cttcttctat tctctctatt atcttttttg
     5821 aatctaaaat agttagactg tctattactc taattaatga aaaattcttt acaatagaat
     5881 catttatgtt ctttattttt tcattttcta ctactctact aaatattcta aaaacatcat
     5941 cttctccttt tcctgatatt atatcctcta acaatataaa atccacccca ttcacatttg
     6001 gattagcagt tcctactata gccatcacat catacatttc aaaaactggt tctttatctc
     6061 ccatagaaac aagactatca taatcataag gtattatttt gacatcaact atcccaatta
     6121 aactttcgga aagtagatgt tggattttta tagcagtacc tatccctgta aaacaagatg
     6181 atattatagc atattcttta tttttttgag gataatacaa ttgtatatta ggtttagttt
     6241 cttcatccat aatttctgca atctgttcaa tgtttttacc ttgcattaat aaatttccta
     6301 cttctagtgc agaaatagtg gatatttggt ctataaataa cattggccca tttatcttat
     6361 tttttaaatc ttcatagata agattaagag agcccatatc aaataacaca attaaaccat
     6421 tctttatcct atctccttct aggtatctag acatttgttt tgatacatca gcaatggtag
     6481 catctatagg catatcaata gctgtaaata tatttttacc caacatccga ttacatacat
     6541 tcgccatact actggcagta gcatatccat gtgctataat agtcgcatta acttgattaa
     6601 atttcattct tataattgtt gatttaataa atataatcat tatgattgta tctacattat
     6661 taagatacat atccaatcta ttcgttatta atgttgatat tttacttatt atagagtatt
     6721 ctttgtaact ctcttttttt aaatatatta gtaatttact ttctaaagct ttatactcat
     6781 cagataattg ataagattcg tccttcaaat aaagataaga cgaaaatgcc aatacattat
     6841 tcccatcgta ttttatattg ttattaactt ctaaatttct aaatatatcc tgcattatcg
     6901 atattataag ctccataagt acgttattat tttcatcatt atttgaaaag actaaattgt
     6961 ccattagtct aatcattaga ttagaactct ttttactaaa tatttctttt gttatttcat
     7021 ttttttctag tctatcaaag tagtctaaac attttatgaa actttgatag attatatttc
     7081 ttttatttct tccatttgac atttcaatac taaattgttt aggagaaaag ataatgcttt
     7141 tgcttttacc actttggaat tgaaatatat ctacattttc tatataaaga tttctaggga
     7201 ggtcttgaag agtaacaaaa atatttccat ttcttctttg attttttgca taagctcgtc
     7261 cacatgcata ttttattaca tttttacatt cacctatatt ccccttgaat tttatcttta
     7321 aaatcgtatt taatgtaatt tgagttatct ctataggcaa gccaagtacc ttactttctt
     7381 cataaataaa atgttctaca atctttcttt tttcaatagt ccctctttct tctatattgg
     7441 gaacataaat atttatgggt attcttctta aaaaagtttg caaaaatttg gatagacttt
     7501 ctgttgttgc aaatattaat cttaccctag cttttctaat tactccattc tctccaatcc
     7561 tagaaaacgt acctgtatcc ataaatgtaa ataacttttc ctgaccttca ctatttaatc
     7621 tatgtacttc atctaaaaat aaaacaccac catctgattg ttctattaga cctgctctag
     7681 attcatttgc tccagtatat gctcctttta catgcccaaa taatagacta gacaataact
     7741 ccaaattatt ataatactgc gcacagttta acacattgta tggagaattt ttttctaata
     7801 cattactgct tacactatat ttgtatatta tcttggctaa aaaagttttt cctactccac
     7861 tttcacctgt cagcattatt gtaagtccgc catttggata aagtacagcg gtttttattt
     7921 gttcgattac ttcttttaag ctattatcat atcctatgat actattaaac acagtctctt
     7981 gctttaataa tttacactca tttttaagtt catctaaatt ttcataaata cttttttttg
     8041 taggtcctac tacatcattt attttatttt taggtaaaaa aataacaggt ctactgttta
     8101 tctttataag attatcagat tttactaaat catttaataa tctacttgat tgagttctac
     8161 ttaaattaaa cttttttact atatcttctg ttattatgcc actttctttt ttaagttcat
     8221 caaagttgtt aaataataca cattcattta caaaacttaa aatttcatcc ctcatgttca
     8281 acctccaata caaatatcaa taatactata atattagtat atcatttata tatttatgaa
     8341 aaagataatt atattcctat cttgattctc ttttgtaagg ttgtaaaatc aaacttttta
     8401 taagtataaa atctagattt tttaacataa tctcaaggtt cttatctttc catatatctg
     8461 acatagaatt tatataagaa tatatttatt gtatttatta taataaaaag taaaacatta
     8521 taggtatttt aaaacttatt agcgaagaaa atatttgtaa cttttattac cttatgaata
     8581 ttatttcaaa tttaaaaagg ctataaataa atttattttt aaataaatct acttataacc
     8641 tcacaataat acttataaat tttatttttt cacaatgata tatctcaaat atagttaaaa
     8701 atatatctat ttaattatta atatttaagt aataaattct cactcaatca ttaaattcct
     8761 ttttatagta aattactctt attttactta taccaaatac atttatgtat agatataaat
     8821 aagtactaaa aaaacaattc aagaaaccat atagtaaact taattacatc tgttatttgc
     8881 tcatatcttt agacttatct atacaagcaa caatagattt tataactgct gctctaaagc
     8941 cttcttcttc taatacctta acagcttcta tagtagttcc tgctggagaa caaaccatat
     9001 cttttaattc acctggatgt tttccagttt caagaaccat cttagctgac cccattactg
     9061 cttgagatgc aaatttataa gcttgttgtc ttggcattcc agctaatact gctgcatctg
     9121 ccatagcttc tataaacata aatacatatg caggagaaga accactaata cctgtaactg
     9181 tatccattaa atattctgat actatttctg cctcaccaaa agattcaaac agagccttaa
     9241 tcatatttaa ctcttcatct gttacattac tatttttaca aagagctgac attccctcgc
     9301 caacaagggc tggagtatta ggcattactc ttactatttt tttatctgaa cctataaaac
     9361 tttccagact ttctatagtt ttacctgctg ctatagatac tattatttta tttgcatcta
     9421 ttaattcttt aagtggagtt aaagcctttt cgcatatatt aggtttaagt gctactatta
     9481 ccacatcaga atttgtaaca gctacctttg aatcagttgt agtatttatt ccaaattctt
     9541 cttttacttt atctaaggca acttggctta aatctgatac agttatatct tctgccttta
     9601 ctaatcctga ctgtactatg ccacctatca ttgcacttcc catattccct gaaccaataa
     9661 atcctaaagt tttcatatca aatctccttt tttctattag ttttatttta aagtagctaa
     9721 attgacttta ttttaactgc ttaaaattat cttattttta taaaatataa ccttattata
     9781 actataataa attattcttt tgtatgtatt acttactaat atgtgtatga tttactaaat
     9841 ataaatttaa cgattttttc attaaactta acgagctaac ttcctattta gaaagttagc
     9901 tcataattaa tctaaaattt taaaaatgga atcaaaccat ttatacttta ttatatcagt
     9961 tacgatttta tatagtaaga agttttattt acaagcaaac ctagaatgtt tgctcagttc
    10021 ttcctattat ctcatcttgt agtgttctac ttaaattatt gaaatggtca ctatatcctg
    10081 caactctaac tattaagtct ttataatcct taggattctt ttgagcctct aacagtacat
    10141 ttttatcaaa tacattaaat tgtatatgat gaccatccat attaaagtat gctcttacta
    10201 gattagccat attatctaac cctttttctc cttgaactac tgatggtgca aatctttgat
    10261 ttaataatgt tccaccagtt tttatgtggt ccatcttagc acaagatttt ataactgctg
    10321 taggtccatt agtatctcca cctttttcag gtgaaattcc ctctgaaact ggttttgcac
    10381 aaagtctacc atttggactt gctcccataa tttctccaaa gtatatatga caagttgttg
    10441 gtaacatatc tactctgtat tctccaccac aaacagttag tctaccagtt acctcattgt
    10501 aatatgcatt gaatatctct tgcattattt catcagcata atcatcatca tttccatatt
    10561 taggagtctt atttgaaact aaattaagta tagcttcata tccttcaaaa ttagcatcaa
    10621 gtgctttaag caatgtatcc atatcgaatt ttttcttatc aaatacatta tattttattg
    10681 ctgttaaact atctgttata gttcctatac caacaccttg tatatatcta gtgttgtatc
    10741 ttgctccacc tctttggtaa tccttgcctt tttctataca atcatcaact attgtagaca
    10801 taagtggaca aggcatgtgt tttgcacata tattttctat cacagcattt ccttctattt
    10861 ttatgtcaat catataatgt aattgctttt taaatgcttc aaatagttcc tcataagatt
    10921 ggaaatttct agggtctcca gtttcaatac ctatttgttt tttactaatt gggtcatatc
    10981 cattatttaa tgttaattca agtatttttg gaatgttcat atatccagtt agaacatatg
    11041 cttctttacc aaaacatcca gtttcaacac aaccactggt tccaccaagt cttgcatctt
    11101 ctatagtttt tccagcttcc ataagctctt gaactattgc ttcagtatta taaaatgctg
    11161 gttgacccca tccttttctt gatatttcac aagctctctt taagaatttt tgaggagtct
    11221 ttttacttat ttgaacattt gaactaggtt gtatcaattt catttcatcc ataacatcaa
    11281 gtattatata actaacttca ttaacaccat cttgaccatc tggatttatt ccaccagtgt
    11341 ttatatttgc aaaatctgta tatgtgctac tttcttttaa tgttatacca acttttggtg
    11401 gtgctggctg attgttaaat ttaacccata aacattcaag taattcttgt gctctatctc
    11461 tatctagtat tccattttct acatctcttt catagaaagg atttagatgt tggtcaagtc
    11521 ttcctggagt aaaagcatcc catatattaa gttcagtagt aacccctata tgaacaaacc
    11581 aatacatttg tatagcttga tgataagttt ctggtttgtg agctggtaca acatcacaag
    11641 tttcagcaat tagtaataaa tcttttttct tagcttcatc tgtttcttct tctgccattt
    11701 gtcttgcttt ctcagcatat cttttaccta atataaccat tgcatcacaa gctattgcca
    11761 tagcttctaa atctgctttt ttattatatg catctaaatc attaagaaaa tctagctctt
    11821 ttaatcttgc ttctatgtct ttctttaaat ctaaaaatcc ttttttatat attgtatctc
    11881 cacaaactgt atgtcctggg gctctttgtt ccataaactc tgtaaacata cctgcttcat
    11941 atgctgctaa ccactcaggt gtcattgcat ttattatctt atctcttgtt tgtctttttt
    12001 tccaaaaagg aattatttct tctttatgta tttttctagc ttcttctgat acgctaaaat
    12061 ttattatatc tctattgtgc attacttcta aatcttccat tgtgtgacaa caaatttctg
    12121 gatatgttgg tgctccatta ggagaatcac ctttttcacc tactattaat tctccatcat
    12181 ttatgctaag agttctattc tcaatataat gcttaaatga taaagcacga agtacaggaa
    12241 tctctacact tccctcatat tttttataag cttctgtcat aagtactgct ctttcaatag
    12301 atatgtgtgg ttctgcatta atactttctt ctcttaattt tttagttctc tcaaaagttc
    12361 ctcttgccat tttattaccc tccaatctta gtattgaaat tacttgcttc aaacagtctt
    12421 tttatttcct ctaatttttc ttctgatggt ctttgtagtt cttctccttc atacttttta
    12481 taaattttat catacttgtg tttaccaata ttatgatatg gaagaagact tactgcttgt
    12541 atattcaaag gctttaaaaa ctctatcatt tttttaacct ctaaattttc atcatctaca
    12601 tttactccta caattaatgg tattcttata tttatgttaa cccctaattc acttaaaatc
    12661 ttaacatttt tcagtattaa gtcatttgat tttcctgtaa attttatgtg cttatcctca
    12721 tcaataagct taatatcata taaaaacaaa tctgcacatt tagcaactct ttcataattt
    12781 tctgactttg catagccaca tgtatcaatt gctacatgga ttccctttga tttgcacatg
    12841 tttattactc cacaaatgaa gtccatatct tgagccatta cttctccacc tgatagtgtt
    12901 actccaccac ccgattcttc atagaaaatt ctatccttct ctatctcttt aaccaagtct
    12961 cttacagaat actcttgacc aacaatctct cttgcattgt ttacacaata gtctaagcaa
    13021 gtttcacaaa actcacactt atcttggtct aagcatattt ttgtttcacc tttgtaaatt
    13081 gccttatgag ggcatatatt tatacatgct tcacattttg aacatctttc ttcattatac
    13141 aaaacttgtt ttgtatatgt ttgactctct ggattatgac accaaacaca ttcaagtgga
    13201 caccctttaa aaaatactgt acttcttatc cctggtccat catgtatgct acatttttgt
    13261 aagtttataa ctaatggatt catgattttt cacccctaaa taatatccat tccatttttt
    13321 catttttatg caattcatct tcatagaata tacctatgaa aagcatttct acaattacat
    13381 aatactatat ttgttattat tttgtctata tatttttagt aatattaaaa aattttattt
    13441 tattatgata tttatattgt ttttgtaaat taaatttaaa tatttattaa atttattttt
    13501 ataagaaaat atagcaataa actataaaca atacatcatt ttaattaatt tagatgtata
    13561 tactataaaa attaaataaa aatagagact acactttacc atgtagtctc cttctttctg
    13621 gtcatattta gaaattcaca tttattgtta ctgcttttcc gcctctattt actgttattt
    13681 ttgtactagc accttttgag aaagtataca actttttatt taaatcattc atacctgtta
    13741 tatctgtatc tcctacttta gttataatat cccctacctt tactccagct ttttctgctg
    13801 atgaaccaga tattacttct gcaacataaa cacctttatc agtacttaat tttgtacctg
    13861 ttgctgcttc ataatttgat acatctgtac cttttatgcc taaagttact ttttcatatt
    13921 ttccattttt gattacttct tcaactatac tcttagctgt attgattggt attgcaaatc
    13981 ctaatccttc tgcttgagaa gcttttgctg tgtttatacc aattacttga cctttttgat
    14041 ttaacaatgg tcctccacta tttcctgcat ttatacttgc atcagtttgt aataaaccag
    14101 tcatattagt tttttctgtt tgtatagttc tatctaatcc acttattatc ccttgagtaa
    14161 ctgttttttg aaaatctaat ccaagaggat tacctattgc tattgatata tctccaactt
    14221 ttactttgtc actatcagca aattctgctg gtgttagtcc agttttatca accttaacta
    14281 tagctaaatc aagttgttgg tcaaaccata ctactttacc tgaagttgtt gaaccatcat
    14341 tgaataatac atttacactt gtagcttgac catctgatat aacatgagaa ttagtaagta
    14401 tatatccatt tgaatcaact atgattccag ttcctacacc ttgtgtttca gttggtattg
    14461 caaacatatt actagtatca acactagttg ttgtaatacc tacaacagat ggcgtagctt
    14521 tttctgcaac tgcttgataa atattttgac tcttaccatc atcatttaca actatcggcg
    14581 tagaacttcc tgtagatttg cttactaaat tgtccttaac taaaattatt gttagaaaac
    14641 tactaagtat tgaacttatt atagcaacta atattactaa acttatccct ttctttcttc
    14701 ttgacatctc ataccactcc ctatcttaat ataatataaa ttatcaaaat atatttttcc
    14761 caatttttca taaaaaaaat gaaatcatct attttgagta aactcctttt cgatgatttc
    14821 attatattat tttaatctta attaaacctt aactatttaa aattatttaa gtcttttttc
    14881 tagctcttcc ttttcttttt cataacctgg tttgcctagt aaagcaaaca tatttttctt
    14941 gtaagcttct actcctggtt ggtcaaatgg attaactccc aataaatatc cacttattcc
    15001 acaagccttc tcaaagaaat aaactaaata tccaaaatta tactcatcta gttgaggtat
    15061 atttattact aaattaggta cttttccatc tgtatgagcc aatagagttc cttcaaaagc
    15121 tttatgattt acaaaatcta cagtcttacc tgctaaataa tttaaaccat ctaagtctac
    15181 ttcctctgaa cttatagtta tatttctctt acagttttca acattaagta ctgtctcaaa
    15241 taaaagcctt tttccatctt gtatgtattg acccatagaa tgtaaatctg ttgagaaatc
    15301 tacagaagca gggaataaac ctttattttc ttttccttca ctttctccat aaagctgttt
    15361 ccaccactca cttacataat gtagttgagg ttcatagttc actaataact ctacatcttt
    15421 tccttttcta tgtaaaattg ttctagcaac agcatatcta taactatcat tactttttaa
    15481 gtcaggattt tgaaatgctt ctctagcatc atttgcgcct ttcatcatag catcaatatc
    15541 aagtccagca gcagcaatag gaagtaaccc aactgctgtc aatacagaaa aacgaccacc
    15601 tacatcatct ggtattacaa aagtctcata tccttcttct gtagctaact gtctaagtgc
    15661 acctttactt gcatctgttg ttgcataaat tctctttctt gcttcttcct taccatactt
    15721 tttctctaag taatctttaa atattctaaa agccagagct ggttctgtag tagttcctga
    15781 tttagatatt acatttacag aaatatcctt tccttcaatt atatctaata aatccataat
    15841 atatgttgag cttatattat gccctacaaa atatacttct ggagcctttc tttgctcttt
    15901 tttaagtcca ttcctaaaag aatgacttac catatctata gcagctctcg aacctaaata
    15961 agagcctcct atacctatta ccagaagaac atctgagtct gattttatct tctcagcaga
    16021 tttttttatt ctgtcaaact cttctttatc ataattttta ggaaggtcta tccatcctaa
    16081 aaaagtattt cctaaaccag ttttattatg taacatgtcg tgcgcaacat ctacatatgg
    16141 ttgcatgaca tctatttcgt tttgacaaaa aaactctgta gctttactat aatcaaaatt
    16201 tatttttccc atttaaatcc ctcttttcag catattcgtt ttaaagagat tataacacaa
    16261 aatataggtg ttttttttaa aagtttgcca caaaatcata catatctcat catttattat
    16321 caggaaatcg attcttctaa atactataac tatgtataaa tttaaaaatt ttagtcaaat
    16381 aaatttacaa aaaaagaaac tctaaacgta tcatttaaag tttctctttt atttatcctc
    16441 tattttaaat tttatattat tttaaattaa ttatttttaa tcatttccta atctcttcgc
    16501 tataacttgt tgtgctatat tgacagcatg gtcagatatt ctctctaaat tacttattac
    16561 gtctaaataa ataactccat tttctatact acatagatta ttgttcaatc tatacatgtg
    16621 attagctcta caagatttct ccattatatc aacttgttct tcaattttta taaccttaca
    16681 agctaaatca acattatcag ttctcattga ttctaatgca taagtatatg ctgaaacaac
    16741 tctattatac ataacatcaa gttcagattg tccttcttct gagaaagaaa tatttgaatc
    16801 tattgcaact tgcgataatt cagctatatt tttagcgtgg tcaccaattc tttctatatc
    16861 attgactgta ttaaacaaag tatccacaac ttctcttgaa tcatcatcta aaggtgcttt
    16921 tgaaagttta agtaagtaat ttaaaatagc tttctgtaaa tcattgatta atctctctcg
    16981 tctatatgtc ttagctattt tttcagttga atgttctact aaggcttcca tagatgcatt
    17041 taggctttcc ttcgccttct cacccatacg aagtgcttct tttatcgtat ttgcaagagc
    17101 tatagaagga gtttctatca ttctatcatc tatatattta atagttttag tttcatcttc
    17161 atctatatca cctgctctat caggaacaag ctttatagct agttttataa taagatttgt
    17221 aaatggtaaa agtatcaata cagatattat attaaacaat gtatgtgtat tggctatttg
    17281 tcttgcaaca ttgcttggat cccaacttgt aaccatgctt actactggtt tattcaagaa
    17341 tattaagaat atcaccgttc ctaaaacatt gaagattaga tgcatcatag ctgctcttcg
    17401 tgcatttttg ttagcaccaa tacttgataa cagtgaagtt acacatgtac caatattttg
    17461 gccataaaga attggcagtg ctgctgataa tggcactaga ccttctgctg ccagtgcaac
    17521 caacataccc atagatgcac ttgaactttg tattattgct gtaatcccaa atcccaataa
    17581 taatccaagt agtggatatc taccaaatgt aacaagtagg tcagtaaatc cttgatagtc
    17641 tcttagtggc tccactgcca tcttcataaa atccatacct gtaaataata taccaaaacc
    17701 tataagtatt tcggctatat tttttattct aggcttattt ccaaataaat aaagtataat
    17761 acctacacct aatgctactg gggccatacc agttaagtcg aaagatacca attgggctgt
    17821 aacagtagtc cctatattag cacccattat aactcctatt gcctgtttta aagtcattat
    17881 tcctgcattt acgaaaccaa caaccattac agtagtagca cttgaacttt gtattactgc
    17941 tgtaactcct gtacctacca aaactcccat aaataggtta ctagtaagta gttttattat
    18001 cttttttagc tttgtcccag cagatttttg aagaccttct cccataaggt tcataccata
    18061 taagaacaga cctaatccac ccattagact tattataatg ttcaaattat ttcctccttg
    18121 taaagagatt actgtatcta aaaattttat aacctattgt attttatcaa attataggag
    18181 tgataatgtt aaattcatgt taaatattaa aaaatcatta agtttatgtt aaatttttgt
    18241 attattggtg tatttttgta ttattttttc tgcacatttt ataccatcaa ctgctgctgt
    18301 aactatacca cctgcatatc cagcgccttc accacatgga tatagattct taatactcac
    18361 tgattctaaa gtattttcat ctcttactat tcttattggt gatgatgacc tagtttctac
    18421 tcccgtcaaa acagcatcat acattgcaaa cccattcaat tttttatcaa gagatataaa
    18481 cgcttctctc atagtctctg ttacgaagct aggcaaacat tcacttaaat ttgtaagtgt
    18541 atatcctggt ctatatgatg gctcaacact tcctaaattc aaagaagtct tattgtttat
    18601 aaaatctcca acaagctgaa ctggtgcatt gtaatttttt ccacctaatt caaaagctaa
    18661 tttttcatac ttctgctgga aatgaacacc tgctagtgga ttatcactct taaaatcttc
    18721 tggcgttaca tttactaaaa atgcactatt tgcatttatt ttatctcttg catgttcact
    18781 cataccattt gtaactattt caaaatcatt tgatgcagat gctatgacac tacctcctgg
    18841 acacatacaa aaagtatatg ctgttcttcc atttgaaaca tgctctataa gtctataatc
    18901 tgcagctcct aacctaggat gattataaaa atccttgtac tgtgctttat ttattaaatc
    18961 ttgtggatgt tcaactctag ctcctattgc aaaaggtttt tgaactattt ttatacctct
    19021 tgaatacaac atttcataag tatctcttgc actatgtcca acagctagta taattgtatc
    19081 tgtatctatt ttttcagtat catttattat tacagattgt atagaatcat ttgatacaac
    19141 tatatctgtt acttttgaat taaatctaac ttgaccacct aaacttatta tttcatttct
    19201 tatattttta actacatttt ttaatatatc tgttccaaca tgtggcttat gtgagtataa
    19261 tatttcatct ggtgctccaa actgaactaa ctcttctaat acttttctac atcgtatatc
    19321 ttttattcta gttgtaagtt taccatccga aaaagttcct gctccacctt ctccaaattg
    19381 aacgtttgaa ttatttttta attttctagt tgtccaaaaa tcacttatat ctttggttct
    19441 actgtctaca tcaagacctc tttcaagtat gattggttca taacccattt gagctaaaag
    19501 cagacctgca aataaaccag ctggtccact accaattacc aaaggattat tctttaattt
    19561 tttatcaccc acaggtacat ttatgtatct gatttccttt atttttgtta catcttttat
    19621 ttttgagtta agtattttat tttcatcttt gacttctaca tctacagaat aaacaaattc
    19681 catttttcct ttttttctag catctataga ttctttatat atactatatt tgactaagtt
    19741 tttttctttt atttttagct tcttaagtac aacatctttt aataaagata tatctttatc
    19801 aattccaagt tttacattag atactcttaa catattgttt tcctctctta gattgtaata
    19861 taaaaaagct agggttattc ctagctttct acaaatataa cttctatatt ctcttttact
    19921 agattttcta cccaaatctc atctagcaca aaattcttta ttttgtttac aacaagtgtt
    19981 ttatctaaat cctttttcaa gttttttact aagaccattg cttcaactga tttatgcaat
    20041 ctttcaacat acagagaatt aactttaatc aatacaaccc ttaattcaca cacatataac
    20101 ttttcactac ctaaggtgat ttcatcatca tattcatata cactaaattc atatgtattt
    20161 tcataaggtg ttatattttc tattcctata tagtccattt atttatcctt ttttagttat
    20221 aagacctctt ataaccttca tgttattaaa caccttttct aagaagttct ctgcttcttc
    20281 attgtctaaa aggtttattt caaggttttc gttttctaca atacctttag atttacagta
    20341 ctctttagca acatttatta gttcattttt tttatccata gataaatcaa actctttata
    20401 gtctattatt atatattgtt tggtatcagg tgatacacca ttattatatc ctatttctat
    20461 atgataaata actgcatata tttcttctcc gttgtacaca ggtacagctg ggttagattt
    20521 tataaagttc gttgatacag caattgcatt tcctaaacta agactcatta ttaatacctc
    20581 tttctaaaca ttatacatat attatactat agattcttta tctatgactt aaagcttttt
    20641 ataattaatt aagatatttt taaatctttg tatctctttc ctagtgtact agagcttata
    20701 tcgtatttct ttgatatttg aacttgagtt ataggttgtc ctgcttcttt tttaacatag
    20761 tattcaacag cagctgccca accattttca gctcctttta tattttcatg atttttctta
    20821 tattcattcc aaaactctat acatgcatct atattttctt tttctacatt ttctttaaga
    20881 gtatctaaaa ctttacattc ttcttcagct aattcatttt ctgaattaac ttttgtatcg
    20941 tttttatctc tttctctctt taaatattca gctatacttg ggtctaaaag ctgttgtata
    21001 tacttgtata gtatatgtgt atgataaatt aagaacgact tcatatcttt gtatacatct
    21061 tgatattgat tgaatagatt cataatatcc tttaaaatta tatctttaac ctcatttgat
    21121 atacttatag ttatatctat caatatgtta gttccttcaa tatcaactat tctagctatc
    21181 atacaacttc cgattttaaa acttctcaga agttttacat cttctgtaca aagttcattt
    21241 ccacttaaac agtcctttaa tactattttt ccagcagaaa cttcttttac ctcataaata
    21301 cttacgtatg attcaaacat actttttaat attgatactt ctgattgact taggtttgca
    21361 ccattttctt caagaaaacc aactgtcata acctttttat tttccattat gtggtcttgt
    21421 attaaataag tattaaaaaa tctttcaaat ttttcattta cactatcatt ttgcattata
    21481 taaaacattt ctttagcttt ttcacattct tctttaaact tatcctgtct tgaataatca
    21541 tataactttg aatataaatc tgtatattgt ttttgtgaaa gttcagtttt tctgcatgct
    21601 ctttctgaaa caatatcttt atttaaacaa catttcttgt attttttgcc acttccacaa
    21661 gggcatagct catttctccc taacaatatg acttccactc ccttattatt aaattaaagt
    21721 acaatttgtt attataccat ttttttatta atcaatctat agtataagta aatattctat
    21781 taaattcact tatattttgg tacaatatat taactttaat taggatttcg ataaaatcat
    21841 caacaatccc tcttgtagaa atgaattatc gtaaaactaa ttcctctata aaattttatt
    21901 aattgataat agttttttac tttatctatt cttttttgtt atatgactct aactgtcatt
    21961 ttacattcaa caatattgtc tttttcttgt ttatattcat ttggaatatt ttgaacatca
    22021 aaattattga cttttaattt gttaatttct atcttttcaa gtttattatt tagtcttaac
    22081 ttcttcatta caccttcaag tttcaacaca tttgcaagtt ctccattaac ttttatttct
    22141 aaattaactt gttttttatt gtgattatct aaactacttt cttgattaat atattctaca
    22201 ttcacaatat ctctcagttc attttctact aataacacta tatctttatt tgttttttta
    22261 tctaaaaatg agttattaaa attatttttc aattcttcat ttttatttaa ttcaacactt
    22321 tctatatatt tatcatctat atgcttatta tcctttattt gataattatc
//
