LOCUS       FN545816               26028 bp    DNA     linear   BCT 27-FEB-2015
DEFINITION  Clostridium difficile R20291 complete genome.
ACCESSION   FN545816
VERSION     FN545816.1
KEYWORDS    .
SOURCE      Clostridioides difficile R20291 (Clostridium difficile R20291)
  ORGANISM  Clostridioides difficile R20291
            Bacteria; Firmicutes; Clostridia; Clostridiales;
            Peptostreptococcaceae; Clostridioides.
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-32bee55(changed)
            Run date     :: 2021-04-09 12:09:52
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1115677
            Orig. end    :: 1141705
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..26028
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[1125677:1131705]"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..16028
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
     cand_cluster    1..26028
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /kind="single"
                     /product="acetate2butyrate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..26028
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="acetate2butyrate"
                     /region_number="7"
                     /rules="(not (POR or POR_N or PFOR_II) and minimum(4,
                     [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF, ETF_alpha,
                     HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and minimum(1,
                     [EC1_2-faecali, ECH1_Enoyl_CoA_DH1, ECH1_Enoyl_CoA_DH2,
                     ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4, Thiolase_C]))"
                     /tool="gutsmash"
     gene            1033..2084
                     /locus_tag="CDR20291_0901"
                     /pseudo=""
     CDS             join(1033..1785,1785..2084)
                     /codon_start=1
                     /db_xref="PSEUDO:CBE03037.1"
                     /locus_tag="CDR20291_0901"
                     /product="putative membrane protein (pseudogene)"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSILENNFLYKLKNNTIFFCIYTLLFIFIYKAFPYIAPFFLGAII
                     ALMINPIAQKLENKFRINKGISTLVLSFLAVAIVSTVTTIIVINSMKELMGFLNNISAN
                     PEDISNTIMYFLNKINDFMKSFQEIANFDVEQLVNKFSGEVMQITKNLLTSILGLATSI
                     PYIIIFIITLFIATYFIAKDLDKIENSFYNMFTVDVRKKVKNVKKEAGLSLVGYIRAYT
                     ILMAITFFAIWGSFALFGLKYGLIVGFVGALMDLIPFLGIITIYLPVIVYYFLIKNYFI
                     AISMTVIFFVLSLIREILEPKLVSVNVGLNPLATLAAIFIGIQVKGIIGVIFCLGLVCM
                     HDILKKVDIF"
     gene            2175..3401
                     /gene="pepT"
                     /locus_tag="CDR20291_0902"
     CDS             2175..3401
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0902"
                     /db_xref="EnsemblGenomes-Tr:CBE03038"
                     /db_xref="GOA:C9YK01"
                     /db_xref="InterPro:IPR001261"
                     /db_xref="InterPro:IPR002933"
                     /db_xref="InterPro:IPR010161"
                     /db_xref="InterPro:IPR011650"
                     /db_xref="UniProtKB/TrEMBL:C9YK01"
                     /gene="pepT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M20"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CDR20291_0902"
                     /product="peptidase T"
                     /protein_id="CBE03038.1"
                     /sec_met_domain="Peptidase_M20 (E-value: 1.2e-15, bitscore:
                     55.5, seeds: 360, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQKVVERFLKYVSFDTTSNSQCENCPSSEGQRVLAKYIVEELKT
                     MGVDDVSLDENSYIMATLKGNTDGVDTIGFISHLDTIEDVSGKDIKPRIIENYDGKDIV
                     LNEALNVITYVKDSPELEEFKGDDLIVTDGTTLLGSDDKAGIAEIVTAIEYLINHPEIK
                     HGDIKIGFTPDEEIGRGADLFDVEKFGAKYAYTLDGGIVGELECENFNAANATITIHGR
                     NVHPGSAKNKMVNAIHIAAEISEMFPADERPETTEGYEGFWHLNSIGGNVENVSMAYII
                     RDHCREKFENRKSIMIENIEKINKKYDNRVELDLKDSYYNMKEKIEPVMFIVDIAKEAM
                     EELGIKPRLVPVRGGTDGARLSFNGLPCPNIFTGGLNFHGKNECIPVSSMEKATKLIVR
                     IAEKYAERV"
     gene            3659..4660
                     /locus_tag="CDR20291_0903"
     CDS             3659..4660
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0903"
                     /db_xref="EnsemblGenomes-Tr:CBE03040"
                     /db_xref="InterPro:IPR007253"
                     /db_xref="UniProtKB/TrEMBL:C9YK02"
                     /locus_tag="CDR20291_0903"
                     /product="cell surface protein"
                     /protein_id="CBE03040.1"
                     /transl_table=11
                     /translation="MLPSCVYADTISKNQNAQVDMNNYLQGRKSPKEEKLIGEDRFDTA
                     IKISQSGWNNGSERVFLVNSNSLPDALASTPLASKLDAPILLTNKNSIPYNVTEEIKRL
                     NPAEVILIGSEGAISSSVKESLEDMEVLVSRIGGADREETSLLLTRQLDDTGDLGVSKV
                     AVVNGYNGLADATSISSPAASDNTAIIYTGKDSIRSEAKNFITQNSTKTYIVGGEYSIS
                     KKLEGQLVNSERLAGTDRKDTNAKVLEKFYGKSSKVNNMYFAKDGSGREADLVDGLAAG
                     VLASKTKSPVVLASGSLSSAQKSFIKKVKADKFVQVGGGKNSKPYAEALALQ"
     gene            complement(5078..5647)
                     /locus_tag="CDR20291_0904"
     CDS             complement(5078..5647)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0904"
                     /db_xref="EnsemblGenomes-Tr:CBE03042"
                     /db_xref="InterPro:IPR000979"
                     /db_xref="InterPro:IPR024654"
                     /db_xref="InterPro:IPR029052"
                     /db_xref="UniProtKB/TrEMBL:C9YK03"
                     /locus_tag="CDR20291_0904"
                     /product="putative phosphoesterase"
                     /protein_id="CBE03042.1"
                     /transl_table=11
                     /translation="MKIGIMSDTHGSLLYFEKALNVLSDCDVLLHGGDVLYHGPRNDIP
                     EGYNPKKFIETLNKLENIVIVKGNCDADVDQMVIEHPIQSPYVMSQFGEIRIILNHGYI
                     ESEEEIIDKAKKMGGDILVLGHTHVKKLYMDDNLIVINPGSTSIPKDGSHSVAIIDIIK
                     TDDEDELELDINLIDINTGNIININD"
     gene            complement(5672..6472)
                     /locus_tag="CDR20291_0905"
     CDS             complement(5672..6472)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0905"
                     /db_xref="EnsemblGenomes-Tr:CBE03043"
                     /db_xref="GOA:C9YK04"
                     /db_xref="InterPro:IPR002504"
                     /db_xref="InterPro:IPR016064"
                     /db_xref="InterPro:IPR017437"
                     /db_xref="InterPro:IPR017438"
                     /db_xref="UniProtKB/TrEMBL:C9YK04"
                     /locus_tag="CDR20291_0905"
                     /product="putative inorganic polyphosphate/ATP-NAD kinase"
                     /protein_id="CBE03043.1"
                     /transl_table=11
                     /translation="MKRIITINTNQLNKSLETKELLTRKLINAGFEVYSDIYPDTELII
                     SIGGDGSFLRTVRDFDFPEIPIMGINTGHLGFFPDILPDKIDSFIEAYTKKDYIIQEMS
                     LLNAEVYTTTSGSNMLAVNEVVIRGDKSRTIHLNLSLDNKHIQNFSGDGMIISTSTGST
                     AYNYSAGGSIVDINLELMQITPLHPINTNAYRCFTSSIICSNESVIKIAPEYRFEDSVL
                     IVVDGVEHRFRQIENIKVSISDAKIKLLRMSNYEFWHRVSEKFL"
     gene            6574..7479
                     /locus_tag="CDR20291_0906"
     CDS             6574..7479
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0906"
                     /db_xref="EnsemblGenomes-Tr:CBE03045"
                     /db_xref="GOA:C9YK05"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:C9YK05"
                     /locus_tag="CDR20291_0906"
                     /product="ABC transporter, ATP-binding protein"
                     /protein_id="CBE03045.1"
                     /transl_table=11
                     /translation="MGIKKCIRGEDVFSIRNITKKLGKFKLNNINLELKEGDIVGIIGP
                     NGSGKTTLIKIIMGIIDADEGEIELCNETIENSPISFKNNIGFVYDSLQFYPHLKVKEF
                     RKIVSLFYKNFDREKFDEYLNKFDIEENMHIENLSKGQSEKLMLSSALSHNAKLLILDE
                     PTAGIDPIVRTEIMQYLQDFVKNGSSSVIISTHNTDNLIKIADYLVFINRGNQIFTVKK
                     ELIEQEYKIIRANKAELEAIKESIVGVKEYKYYNEALVKVGDSLKVKSLLIEIDKHKVK
                     NPTIEELMYYYVNEVRGCSI"
     gene            7467..8153
                     /locus_tag="CDR20291_0907"
     CDS             7467..8153
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0907"
                     /db_xref="EnsemblGenomes-Tr:CBE03047"
                     /db_xref="InterPro:IPR025699"
                     /db_xref="UniProtKB/TrEMBL:C9YK06"
                     /locus_tag="CDR20291_0907"
                     /product="putative ABC transporter, permease protein"
                     /protein_id="CBE03047.1"
                     /transl_table=11
                     /translation="MFNLIRKDLIIGISSDGIRNLKYILLFFVFYFFLNSISYYTVSIV
                     VSYLIFINTFECDYENDSRIFIRSMPVSIEDIVYSKYLLGVGLIISVTIIVSLLSKLTS
                     LVFFRNMVLNDVFFSVNIFLAILTILLPLIFKFGYGKMKVCGFIVSILIYFVYGSLLKM
                     ISMIVYQVKHFNYSKVGGVYLSNYVTDIANTKYINLYSMTFLTIIIFIISMYFSIKISK
                     KNKFNY"
     gene            8205..8747
                     /locus_tag="CDR20291_0908"
     CDS             8205..8747
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0908"
                     /db_xref="EnsemblGenomes-Tr:CBE03049"
                     /db_xref="UniProtKB/TrEMBL:C9YK07"
                     /locus_tag="CDR20291_0908"
                     /product="putative membrane protein"
                     /protein_id="CBE03049.1"
                     /transl_table=11
                     /translation="MKKFIKVSFFILGIFTLFIAINKLVYRDMVSVKDYEINHLEEIVF
                     DFDSRRSRDIGTIVRFKISNNSKYSYKLNSAKMKFENCVENKKGMNKCSAYVNVDLFNE
                     KNSITESTLKYGIKPNNQGYVDFVIPKGLNFDYRYFNESGMSVEYKGEYIVNIPMAKGL
                     YLVVGKNNDTWNANIME"
     gene            8826..9293
                     /locus_tag="CDR20291_0909"
     CDS             8826..9293
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0909"
                     /db_xref="EnsemblGenomes-Tr:CBE03051"
                     /db_xref="GOA:C9YK08"
                     /db_xref="InterPro:IPR007214"
                     /db_xref="UniProtKB/TrEMBL:C9YK08"
                     /locus_tag="CDR20291_0909"
                     /product="putative regulatory protein"
                     /protein_id="CBE03051.1"
                     /transl_table=11
                     /translation="MSISNVREYFKQFGKEDSILEFEQSSATVELAAEAAGVIPARIAK
                     TLSFKIGDDAILIVTAGDAKIDNKKYKAEFNCKAKMLTPEEVLEFTGHAIGGVCPFGLK
                     NSIKVYLDDSMKRFDTVFPACGSSNSAIELTCEEMEKFSKSEKWVDVCKNW"
     gene            10001..11137
                     /gene="bcd2"
                     /locus_tag="CDR20291_0910"
     CDS             10001..11137
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0910"
                     /db_xref="EnsemblGenomes-Tr:CBE03052"
                     /db_xref="GOA:C9YK09"
                     /db_xref="InterPro:IPR006089"
                     /db_xref="InterPro:IPR006091"
                     /db_xref="InterPro:IPR009075"
                     /db_xref="InterPro:IPR009100"
                     /db_xref="InterPro:IPR013786"
                     /db_xref="UniProtKB/TrEMBL:C9YK09"
                     /gene="bcd2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_0910"
                     /product="butyryl-CoA dehydrogenase"
                     /protein_id="CBE03052.1"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.2e-56, bitscore:
                     187.4, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.7e-27, bitscore:
                     93.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.4e-35, bitscore:
                     120.1, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLNSKKYQMLKELYVSFAENEVKPLATELDEEERFPYETVEKMA
                     KAGMMGIPYPKEYGGEGGDTVGYIMAVEELSRVCGTTGVILSAHTSLGSWPIYQYGNEE
                     QKQKFLKPLASGDKLGAFGLTEPNAGTDASGQQTTAVLDGDEYILNGSKIFITNAIAGD
                     IYVVMAMTDKSKGNKGISAFIVEKGTPGFSFGVKEKKMGIRGSATSELIFEDCRIPKEN
                     LLGKEGQGFKIAMSTLDGGRIGIAAQALGLAQGALDETVKYVKERVQFGRPLSKFQNTQ
                     FQLADMEVKVQAARHLVYQAAINKDLGKPYGVEAAMAKLFAAETAMEVTTKAVQLHGGY
                     GYTRDYPVERMMRDAKITEIYEGTSEVQRMVISGKLLK"
     gene            11181..11978
                     /gene="etfB2"
                     /locus_tag="CDR20291_0911"
     CDS             11181..11978
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0911"
                     /db_xref="EnsemblGenomes-Tr:CBE03054"
                     /db_xref="GOA:C9YK10"
                     /db_xref="InterPro:IPR012255"
                     /db_xref="InterPro:IPR014729"
                     /db_xref="InterPro:IPR014730"
                     /db_xref="UniProtKB/TrEMBL:C9YK10"
                     /gene="etfB2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_0911"
                     /product="electron transfer flavoprotein beta-subunit"
                     /protein_id="CBE03054.1"
                     /sec_met_domain="ETF (E-value: 3.4e-47, bitscore: 158.4,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEGFMNIVVCIKQVPDTTEVKLDPNTGTLIRDGVPSIINPDDKA
                     GLEEAIKLKEEMGAHVTVITMGPPQADMALKEALAMGADRGILLTDRAFAGADTWATSS
                     ALAGALKNIDFDIIIAGRQAIDGDTAQVGPQIAEHLNLPSITYAEEIKTEGEYVLVKRQ
                     FEDCCHDLKVKMPCLITTLKDMNTPRYMKVGRIYDAFENDVVETWTVKDIEVDPSNLGL
                     KGSPTSVFKSFTKSVKPAGTIYNEDAKTSAGIIIDKLKEKYII"
     gene            11997..13007
                     /gene="etfA2"
                     /locus_tag="CDR20291_0912"
     CDS             11997..13007
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0912"
                     /db_xref="EnsemblGenomes-Tr:CBE03056"
                     /db_xref="GOA:C9YK11"
                     /db_xref="InterPro:IPR001308"
                     /db_xref="InterPro:IPR014729"
                     /db_xref="InterPro:IPR014730"
                     /db_xref="InterPro:IPR014731"
                     /db_xref="InterPro:IPR018206"
                     /db_xref="InterPro:IPR029035"
                     /db_xref="UniProtKB/TrEMBL:C9YK11"
                     /gene="etfA2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF_alpha"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_0912"
                     /product="electron transfer flavoprotein alpha-subunit"
                     /protein_id="CBE03056.1"
                     /sec_met_domain="ETF (E-value: 3.6e-51, bitscore: 171.3,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 2.5e-35, bitscore:
                     118.1, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNVLVVIEQRENVIQTVSLELLGKATEIAKDYDTKVSALLLGSK
                     VEGLIDTLAHYGADEVIVVDDEALAVYTTEPYTKAAYEAIKAADPIVVLFGATSIGRDL
                     APRVSARIHTGLTADCTGLAVAEDTKLLLMTRPAFGGNIMATIVCKDFRPQMSTVRPGV
                     MKKNEPDETKEAVINRFKVEFNDADKLVQVVQVIKEAKKQVKIEDAKILVSAGRGMGGK
                     ENLDILYELAEIIGGEVSGSRATIDAGWLDKARQVGQTGKTVRPDLYIACGISGAIQHI
                     AGMEDAEFIVAINKNPEAPIFKYADVGIVGDVHKVLPELISQLSVAKEKGEVLAN"
     gene            13026..13823
                     /gene="crt2"
                     /locus_tag="CDR20291_0913"
     CDS             13026..13823
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0913"
                     /db_xref="EnsemblGenomes-Tr:CBE03058"
                     /db_xref="GOA:C9YK12"
                     /db_xref="InterPro:IPR001753"
                     /db_xref="InterPro:IPR018376"
                     /db_xref="InterPro:IPR029045"
                     /db_xref="UniProtKB/TrEMBL:C9YK12"
                     /gene="crt2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: EC1_2-faecali"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_0913"
                     /product="3-hydroxybutyryl-CoA dehydratase"
                     /protein_id="CBE03058.1"
                     /sec_met_domain="EC1_2-faecali (E-value: 1.9e-89, bitscore:
                     297.0, seeds: 67, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSDVKVYENVAVEVDGNICTVKMNRPKALNAINSKTLEELYEV
                     FVDINNDETIDVVILTGEGKAFVAGADIAYMKDLDAVAAKDFSILGAKAFGEIENSKKV
                     VIAAVNGFALGGGCELAMACDIRIASAKAKFGQPEVTLGITPGYGGTQRLTRLVGMAKA
                     KELIFTGQVIKADEAEKIGLVNRVVEPDILIEEVEKLAKIIAKNAQLAVRYSKEAIQLG
                     AQTDINTGIDIESNLFGLCFSTKDQKEGMSAFVEKREANFIKG"
     gene            13921..14766
                     /gene="hbd"
                     /locus_tag="CDR20291_0914"
     CDS             13921..14766
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0914"
                     /db_xref="EnsemblGenomes-Tr:CBE03059"
                     /db_xref="GOA:C9YK13"
                     /db_xref="InterPro:IPR006108"
                     /db_xref="InterPro:IPR006176"
                     /db_xref="InterPro:IPR006180"
                     /db_xref="InterPro:IPR008927"
                     /db_xref="InterPro:IPR013328"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR022694"
                     /db_xref="UniProtKB/TrEMBL:C9YK13"
                     /gene="hbd"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_0914"
                     /product="3-hydroxybutyryl-CoA dehydrogenase"
                     /protein_id="CBE03059.1"
                     /sec_met_domain="HCDH (E-value: 2.6e-36, bitscore: 121.9,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="HCDH_N (E-value: 5e-65, bitscore: 216.5,
                     seeds: 60, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLAVIGSGTMGSGIVQTFASCGHDVCLKSRTQGAIDKCLALLDK
                     NLTKLVTKGKMDEATKAEILSHVSSTTNYEDLKDMDLIIEASVEDMNIKKDVFKLLDEL
                     CKEDTILATNTSSLSITEIASSTKRPDKVIGMHFFNPVPMMKLVEVISGQLTSKVTFDT
                     VFELSKSINKVPVDVSESPGFVVNRILIPMINEAVGIYADGVASKEEIDEAMKLGANHP
                     MGPLALGDLIGLDVVLAIMNVLYTEFGDTKYRPHPLLAKMVRANQLGRKTKIGFYDYNK
                     "
     gene            14838..16028
                     /gene="thlA1"
                     /locus_tag="CDR20291_0915"
     CDS             14838..16028
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0915"
                     /db_xref="EnsemblGenomes-Tr:CBE03061"
                     /db_xref="GOA:C9YK14"
                     /db_xref="InterPro:IPR002155"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="InterPro:IPR020613"
                     /db_xref="InterPro:IPR020615"
                     /db_xref="InterPro:IPR020616"
                     /db_xref="InterPro:IPR020617"
                     /db_xref="UniProtKB/TrEMBL:C9YK14"
                     /gene="thlA1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_0915"
                     /product="acetyl-CoA acetyltransferase"
                     /protein_id="CBE03061.1"
                     /sec_met_domain="Thiolase_N (E-value: 8.3e-104, bitscore:
                     344.2, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Thiolase_C (E-value: 5.1e-53, bitscore:
                     175.7, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVMNMREVVIASAARTAVGSFGGAFKSVSAVELGVTAAKEAIKR
                     ANITPDMIDESLLGGVLTAGLGQNIARQIALGAGIPVEKPAMTINIVCGSGLRSVSMAS
                     QLIALGDADIMLVGGAENMSMSPYLVPSARYGARMGDAAFVDSMIKDGLSDIFNNYHMG
                     ITAENIAEQWNITREEQDELALASQNKAEKAQAEGKFDEEIVPVVIKGRKGDTVVDKDE
                     YIKPGTTMEKLAKLRPAFKKDGTVTAGNASGINDGAAMLVVMAKEKAEELGIEPLATIV
                     SYGTAGVDPKIMGYGPVPATKKALEAANMTIEDIDLVEANEAFAAQSVAVIRDLNIDMN
                     KVNVNGGAIAIGHPIGCSGARILTTLLYEMKRRDAKTGLATLCIGGGMGTTLIVKR"
     gene            16280..17125
                     /locus_tag="CDR20291_0916"
     CDS             16280..17125
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0916"
                     /db_xref="EnsemblGenomes-Tr:CBE03063"
                     /db_xref="GOA:C9YK15"
                     /db_xref="InterPro:IPR002942"
                     /db_xref="InterPro:IPR006145"
                     /db_xref="InterPro:IPR006224"
                     /db_xref="InterPro:IPR006225"
                     /db_xref="InterPro:IPR020103"
                     /db_xref="UniProtKB/TrEMBL:C9YK15"
                     /locus_tag="CDR20291_0916"
                     /product="putative pseudouridylate synthase"
                     /protein_id="CBE03063.1"
                     /transl_table=11
                     /translation="MTLKEVLLDKLNFSVRSLSKMKKEKSVLVNGVYKKPSLKVYSGDL
                     IEVKIDEEKANFEPQDLNLQIIYDDFDIIMVNKPPFMVVHPTKSHYDKTIANGISYYID
                     NQKENVKIRFVNRLDMNTSGLVIVAKNAYAHHTLSTAMSENKVEKKYITVVDGIIKENE
                     GTIDEPIYRPTEDSIKRIIDERGQSSVTHYKVIERLENATVLEVSLETGRTHQIRVHMA
                     HIGHGIIGDELYGYVDEELINRQALHAYKLEFEQPRTKEKLKFKADIPEDMKELISKLR
                     "
     gene            17139..18143
                     /locus_tag="CDR20291_0917"
     CDS             17139..18143
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0917"
                     /db_xref="EnsemblGenomes-Tr:CBE03065"
                     /db_xref="GOA:C9YK16"
                     /db_xref="InterPro:IPR007358"
                     /db_xref="UniProtKB/TrEMBL:C9YK16"
                     /locus_tag="CDR20291_0917"
                     /product="conserved hypothetical protein"
                     /protein_id="CBE03065.1"
                     /transl_table=11
                     /translation="MIIHKFIIHVLDKNSDVPILNDFEGKVNQEVDGFFQKAIKRIAKD
                     EDLRKGVFKDYNDNLIKNCCEQIIYDESTFLKNSKEIASYLFDVMKINAALESCDLAIC
                     LYTIKDEKSVAILKLDYKKLYTHSIEFVDDKFNIQMVSNEIGIPETLRQKQGALISLSG
                     INDEFHLRLLDKDAEKEGSESKFVTEFLNAKKIDDDKYKTKVFKNTAENWITNALSNDI
                     KQAEDVRSILNYTLKEKHEVDINDFVDNSIKDDELKDSFKEHMEEKGLDESFSIDKKWV
                     EKKLKKRSIKTDNGFDIKGNLTDFEDPMKYTVKQNQDGTIDIIIKNVTFYEEK"
     gene            complement(18287..18514)
                     /gene="acpP"
                     /locus_tag="CDR20291_0918"
     CDS             complement(18287..18514)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0918"
                     /db_xref="EnsemblGenomes-Tr:CBE03066"
                     /db_xref="GOA:C9YK17"
                     /db_xref="InterPro:IPR003231"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="UniProtKB/TrEMBL:C9YK17"
                     /gene="acpP"
                     /locus_tag="CDR20291_0918"
                     /product="acyl carrier protein"
                     /protein_id="CBE03066.1"
                     /transl_table=11
                     /translation="MFEKIKEIIAEQLGVDNLDEITMEASLMDDLEADSLDAVEIIMAL
                     EDEFGIEIPDEEAENFKCIGDICKYIEENK"
     gene            18686..19111
                     /locus_tag="CDR20291_0919"
     CDS             18686..19111
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0919"
                     /db_xref="EnsemblGenomes-Tr:CBE03068"
                     /db_xref="UniProtKB/TrEMBL:C9YK18"
                     /locus_tag="CDR20291_0919"
                     /product="putative exported protein"
                     /protein_id="CBE03068.1"
                     /transl_table=11
                     /translation="MKYVGLLLTSVGMFLLIAVNFYYNSITLDMQRIEDYVMETNLILE
                     DVAEKESYVSNEKEDYISRLMHVKKGIENSKTSFLIERYKEYKIKSIESLIYTISEEKK
                     DYLDEVDRYNKLGEKEINKLINKNFLEVTYLSITTYI"
     gene            19159..19365
                     /locus_tag="CDR20291_0920"
     CDS             19159..19365
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0920"
                     /db_xref="EnsemblGenomes-Tr:CBE03070"
                     /db_xref="UniProtKB/TrEMBL:C9YK19"
                     /locus_tag="CDR20291_0920"
                     /product="conserved hypothetical protein"
                     /protein_id="CBE03070.1"
                     /transl_table=11
                     /translation="MTKLEDNMERFFGGCEGFFGNKMLIIIVIVFLLLCTDILEDLLCD
                     DNIWIWVILIVLLLFNFDDGCCC"
     gene            19547..19726
                     /locus_tag="CDR20291_0921"
     CDS             19547..19726
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0921"
                     /db_xref="EnsemblGenomes-Tr:CBE03072"
                     /db_xref="UniProtKB/TrEMBL:C9YK20"
                     /locus_tag="CDR20291_0921"
                     /product="hypothetical protein"
                     /protein_id="CBE03072.1"
                     /transl_table=11
                     /translation="MLDRFFGEEGCFGGGGWWIIVLFFLFLAFGDSWAEFDIMAWIPFL
                     IVLLILCCCGGCLE"
     gene            19760..19960
                     /locus_tag="CDR20291_0922"
     CDS             19760..19960
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0922"
                     /db_xref="EnsemblGenomes-Tr:CBE03074"
                     /db_xref="UniProtKB/TrEMBL:C9YK21"
                     /locus_tag="CDR20291_0922"
                     /product="hypothetical protein"
                     /protein_id="CBE03074.1"
                     /transl_table=11
                     /translation="MLDRFFGEEGCFGGGGWWIIVLFFLFLAFEDCWRDIDIMSWIPFL
                     ILLLITCSCGGFFDGEVGCGC"
     gene            20207..21229
                     /gene="ccpA"
                     /locus_tag="CDR20291_0923"
     CDS             20207..21229
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0923"
                     /db_xref="EnsemblGenomes-Tr:CBE03075"
                     /db_xref="GOA:C9YK22"
                     /db_xref="InterPro:IPR000843"
                     /db_xref="InterPro:IPR010982"
                     /db_xref="InterPro:IPR028082"
                     /db_xref="UniProtKB/TrEMBL:C9YK22"
                     /gene="ccpA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LacI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CDR20291_0923"
                     /product="LacI-family transcriptional regulator (catabolite
                     control protein)"
                     /protein_id="CBE03075.1"
                     /sec_met_domain="LacI (E-value: 5.8e-20, bitscore: 68.6,
                     seeds: 22, tool: rule-based-clusters)"
                     /sec_met_domain="Peripla_BP_3 (E-value: 3.6e-38, bitscore:
                     129.2, seeds: 83, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKMKGNITIKDVAKQAGVSISTVSRVINDSKPVTDEVKQKVLEVI
                     KETGYIPNPLARSLVTKKSQLIGVIVPEVSDSFVNEVLNGIEEVAKMYDYDILLANTYS
                     DKEQELKSINLLRAKQVEGIVMISWIVEQEHINYIQNCGIPATYISKTARNYDIYTVST
                     SNEEATFDMTEHLIKKGHEKIAFIMTSKDDTVLEMERLAGYEKALSNNNIELDKSLIKY
                     GGTDYESGYNSMKELLDDGIIPHAAFVTGDEAAIGAINAICDAGYKVPEDISVAGFNDV
                     KIARMYRPKLTTVYQPLYDMGAVAIRMVIKLINKELIENKKIELPYRIVDRESVTERKK
                     "
     gene            complement(21352..21792)
                     /locus_tag="CDR20291_0924"
     CDS             complement(21352..21792)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0924"
                     /db_xref="EnsemblGenomes-Tr:CBE03077"
                     /db_xref="UniProtKB/TrEMBL:C9YK23"
                     /locus_tag="CDR20291_0924"
                     /product="putative uncharacterized protein"
                     /protein_id="CBE03077.1"
                     /transl_table=11
                     /translation="MNIIQYIFIERGFFMKKLDTESLEKMAKQKNIDKDKIEKMADSYK
                     GKSENELMEELIKIGKNLDGRDEVVSKFKAFLDENQRKKLDNIMEKISDAENQRDTKPA
                     KTKKAKPTKGKSNSPAPKNTPGGQQKKSKGLFKKTKKSNPHE"
     gene            21962..22867
                     /locus_tag="CDR20291_0925"
     CDS             21962..22867
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0925"
                     /db_xref="EnsemblGenomes-Tr:CBE03079"
                     /db_xref="UniProtKB/TrEMBL:C9YK24"
                     /locus_tag="CDR20291_0925"
                     /product="hypothetical protein"
                     /protein_id="CBE03079.1"
                     /transl_table=11
                     /translation="MNNLLFLIGVIALSNGNISIFDDKNKSKGNNRVRKNKKNANDKLS
                     QSTHGNLRFDANDIKRGLRLMDLSEEDLEMGMEIITRTKKYMSRDERKILIKIESVLDL
                     VRGIKKLNNIDMVDTEDETDFFRKMDSDDKKNMMIKEIIDVFPEKRKNSVEKAIGMKKK
                     IDLFAELFLPDDFGEGGFSLSSLANINNLGSMNNLKLLGSLLRGDDSNNDDEDNNDELN
                     YEDEELDCEDKELDDDELTDEGEMEDNEDELVEDKNTGYENIENDEDIVYDEELYNINE
                     QESEYNYNEKNTKTRAKKKR"
     gene            23345..24562
                     /locus_tag="CDR20291_0926"
     CDS             23345..24562
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0926"
                     /db_xref="EnsemblGenomes-Tr:CBE03081"
                     /db_xref="UniProtKB/TrEMBL:C9YK25"
                     /locus_tag="CDR20291_0926"
                     /product="hypothetical protein"
                     /protein_id="CBE03081.1"
                     /transl_table=11
                     /translation="MQDYKKNKRRMMNQPMSTMNEEEVYTDEINSEDMRGFKKSHHHNG
                     CNTDNKCECHDECNPCNPCNPCKPNPCNPCKPNPCDDKCECHDKCKCDCEPCEMDSDEC
                     FENKCGPECCNPISPRNFSVSNAVPFAIEANRIFDTMQFQTFTDATGPNGEPLTFETEV
                     VEVFGSIPSAGQASVTIEKICLSNDGIVIDTGMTTLEDFDLDPLGDIVGRNCETTFEFA
                     VCGERNAECCRQGKGKSVAYKQRGLTVAVRNLVLELRGRCGCTEFVALAFPAVRAGGGC
                     KRRVDYVEFTFNTLSAPICLPADGRAVTLRQEYQTNLTVDCIGKSILKLECNECCEPFY
                     ELIIPNDIDLVLCLQETVSTLISEQIVVLASPNPIQPRLVDTFSKVCDFSQCGPNHGSG
                     KPSCHR"
     gene            complement(24663..25994)
                     /locus_tag="CDR20291_0927"
     CDS             complement(24663..25994)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0927"
                     /db_xref="EnsemblGenomes-Tr:CBE03082"
                     /db_xref="GOA:C9YK26"
                     /db_xref="InterPro:IPR002797"
                     /db_xref="InterPro:IPR024923"
                     /db_xref="UniProtKB/TrEMBL:C9YK26"
                     /locus_tag="CDR20291_0927"
                     /product="putative polysaccharide biosynthesis/sporulation
                     protein"
                     /protein_id="CBE03082.1"
                     /transl_table=11
                     /translation="MIFLKVPYLVLSTVILFISNFIVRIFGFLYKIFLSRALGETGLGI
                     YHMIFNFLMICLAVTTTGIPTALSCLVAKRKALNDRHNTNALFISTLYISFFVALIISI
                     VASFNSSFLSLKFLKDAKLNLFILAVCPAIVIITLSNVLRGYYYGIKNVKIPAIGQIIE
                     QIGKILFVFLLVMYINNKSMNCYIALLGISIGELSNIIFMLICLWRDSSFDNRYIISIK
                     DFYNSSMETLKMSIPITCNRMSNILLQSISSMMIPSRLALSGMTYQQSLSMYGIVSGMV
                     MPFIFLPFTVGSALIVNLIPTISQEMALRKRKSVIKKIKYSILLTLFVGILSSIFFYFF
                     GKDLCILVFKNTLAGEYLKAMFLVPLFMSLNQTLSGILHSIRKELASSINTITGMLIQL
                     IALYVFLPIPGLNIYAYIYTMTIVSIFTCLLHTIVLFKSLKSIR"
ORIGIN
        1 aggtttctct attagtatct aaacctataa aagcaattat atttatatta agaccaatag
       61 tatggatatt taatataatt acaaatatta tatttaaatt atttggtata acaaataaag
      121 gagctaaatc attcataact gaagaagagc taaaaactat ggtaaatgta agtcatgaag
      181 aaggcgtcct tgaaatggaa gagagagaaa tcataaataa tgtttttgaa tttggagata
      241 tgcaagctaa aaatgcaatg gtacaaagaa tagatatggt agctatagat atggaagata
      301 gttatgatga gataatacag gtatttaaaa ctgaaaaatt aagtagaatg cctgtgtatg
      361 aagaaactat agatgatatt gtaggaatac ttaatataaa agatattata tttttatctg
      421 atgaagaaat agagtcattt gatattaaaa attatatgag agaacctttt ttcacgtatg
      481 agttcaaaaa gataacacaa cttcttgaag agatgaaact tgaaaaaagt cagatggcta
      541 tagttgtaga tgagtatggt ggaacatctg gacttttaac tatagaagat ttagtagaag
      601 tcattgttgg agatatagag gatgaatatg atgaagaaga ggatgaaata caagttataa
      661 aagaagatga gtatattgta gatggaagta ctaaaattgg tgatgttaat gaacttattg
      721 gtgtaaactt ggaatctgag gagtttgatt ccataggagg ttttataatt ggacacctaa
      781 gcagattgcc agaagaaaat gaagtaattg aagttgataa tataagattt tgtatagaaa
      841 gtatagaaaa aaatagaatt aaaaaaataa gaatatatac ataatgtaat aatgttctta
      901 aatttattag aagtgtataa atataaaaga tatcttttat atttatacac ttctttttat
      961 tttgtattca aataaaacta gtatgaaatg gacaaaataa aaatataaat tagaagaaag
     1021 gagattttta agatgagcat actagaaaat aattttttat acaaattaaa aaacaacact
     1081 atcttttttt gtatatatac attgttattt atttttattt acaaagcgtt tccatacata
     1141 gctccatttt ttctaggtgc tataatagca cttatgatta atcctatagc acaaaagtta
     1201 gaaaataagt ttcgtataaa taaaggtatc tctactcttg ttctaagttt tcttgcagtg
     1261 gctatagtca gtacagttac tacaataata gtaataaatt caatgaaaga attaatggga
     1321 tttttaaata atatatctgc taatcctgag gatataagta atactattat gtatttttta
     1381 aataaaataa atgactttat gaaatcattt caagaaatag ccaattttga tgtagaacaa
     1441 ttagtaaaca aattcagtgg tgaagtaatg caaattacaa aaaatcttct tactagtata
     1501 cttggattgg ctacttctat tccatatatt ataatattta taattacctt gtttattgct
     1561 acctacttta tagcaaaaga ccttgataag attgaaaata gtttttataa tatgtttact
     1621 gttgatgtta gaaagaaggt aaaaaacgta aagaaagagg cagggctttc acttgttgga
     1681 tatataaggg cctatacaat acttatggct ataacatttt ttgcaatctg gggaagtttt
     1741 gctttatttg gattgaaata cggtctaata gtagggtttg tagggcttta atggatttaa
     1801 ttccattcct aggtataata acaatatatc ttccagtaat tgtttattat tttcttataa
     1861 aaaattattt tatagctata agtatgactg tgatattttt tgttttgtct ttgattagag
     1921 aaatacttga acctaaacta gtatcagtaa atgttggact aaatccatta gctaccctag
     1981 cagcgatttt tattggaatc caagtaaaag gaataattgg agtaattttt tgtttgggtt
     2041 tggtatgtat gcatgatata cttaagaagg tggatatttt ttaattataa taattgatag
     2101 atttttttaa aaataaaatt ttattcacag gtaaataaaa aaatattaat cttattaaga
     2161 aagagggtat atacgtgaaa caaaaagtag tggaaagatt tttaaaatat gtatcatttg
     2221 atacaacatc taattctcag tgtgagaact gtccatcttc agaaggtcaa agagttttag
     2281 ctaagtatat agttgaagag ctaaaaacaa tgggtgttga tgatgtgagt ttagatgaaa
     2341 atagttatat aatggctact ttaaaaggaa atactgatgg tgtggatact ataggattca
     2401 tatcacattt agatacaatt gaagatgtta gtggaaaaga tattaaacca agaataatag
     2461 aaaattatga cggaaaagac atagttttaa atgaagcgtt aaatgttatt acgtatgtaa
     2521 aggattctcc agagttggaa gaatttaaag gtgacgattt aatagtcact gatggaacaa
     2581 ctctacttgg ctctgatgat aaagctggta tagctgagat agtgactgca atagagtatc
     2641 taataaatca tccagaaatt aagcatggag atataaaaat aggatttaca ccagatgaag
     2701 aaattggtag aggtgctgat ttatttgatg ttgaaaaatt tggagcaaaa tatgcatata
     2761 ctttagatgg aggaatagtt ggagaacttg aatgtgaaaa ttttaatgct gcaaatgcaa
     2821 ctattactat acatggtaga aatgttcatc caggttcagc taaaaataaa atggtaaatg
     2881 ctatacatat agctgctgaa atatcagaaa tgttcccagc agatgaaaga ccagaaacaa
     2941 cagaaggata tgaaggattt tggcatttaa attctatagg tggaaatgtc gagaatgtaa
     3001 gtatggctta tattattaga gaccattgta gagaaaaatt tgaaaataga aaatctatta
     3061 tgatagagaa tatagaaaaa ataaataaga aatacgataa tagagtggaa ttggatttaa
     3121 aagattctta ttacaatatg aaagaaaaga ttgagccagt tatgtttata gttgatatag
     3181 ctaaagaagc tatggaggaa ttaggtataa aaccacgttt agttcctgta agaggtggta
     3241 ctgatggagc aagattatct tttaatggat taccttgtcc aaatatattt actggtggat
     3301 taaacttcca tgggaaaaat gagtgtatac cagttagttc tatggagaaa gctactaaac
     3361 taattgtaag aatagctgaa aaatatgctg aaagagttta gttaaaaagt atttaaaaat
     3421 taagcattta aagttataat agctatatca ttctttataa gtcaagctga ttataagctt
     3481 gtgttgtatt taaaatggta tagctatttt tgtaattatt tttataaaag ataattattt
     3541 ttagtttagg gtatcaataa aaagtatgga tatcaatagg tattaacatt taaaaggggg
     3601 aattgtattg aaaattaaat ctaaaaaaat aatagcattt gcactttcac ttgggattat
     3661 gttgccaagt tgtgtatatg cagacactat tagtaaaaat caaaatgcac aggtagatat
     3721 gaacaattat cttcaaggta gaaaatctcc aaaggaggaa aaacttattg gtgaagatag
     3781 atttgataca gcgataaaaa tatctcaaag tggttggaat aatggttcag aaagggtgtt
     3841 tctagttaac tcaaattcat tgccagatgc attggcttca actcctttgg caagtaaatt
     3901 ggatgcacca atactgctta caaataaaaa tagtatacca tataatgtaa cagaggaaat
     3961 aaaaaggctt aatccagcag aagttatttt aattggaagt gaaggagcta tttcatcaag
     4021 tgtaaaagaa tctcttgaag atatggaagt attagtcagt agaatcggtg gagcagatag
     4081 agaagaaaca tctttacttc ttactagaca gctagatgat actggtgatt taggtgtctc
     4141 aaaagtggca gtggttaatg ggtataatgg actggcagat gcaacttcaa tatcaagccc
     4201 agctgcaagt gataatacag ctataatata tacaggtaag gatagcataa gaagtgaggc
     4261 aaagaatttt attacacaaa actcaactaa gacatacata gtaggtgggg agtacagtat
     4321 aagtaaaaaa cttgaaggac agttagtaaa ctcagaaaga ctagcaggaa cagatagaaa
     4381 agatactaat gcgaaagttt tagaaaagtt ttatggaaaa tcaagtaagg ttaataatat
     4441 gtattttgca aaagatggaa gtggtagaga agctgattta gttgatgggc ttgctgctgg
     4501 agtattagca tcaaaaacaa agtcacctgt agtacttgca agtggaagtt taagtagtgc
     4561 acagaaaagt tttataaaaa aagtaaaggc tgataaattt gtacaagttg gtggaggtaa
     4621 aaatagtaaa ccatatgcag aagcattagc cttacagtaa tattgtgtaa atcaaaatta
     4681 atatataata atagcaagta aaccaagttg aacttcaata tatataataa aataagtaaa
     4741 ctaagttata tttcagtata atatataatg aaataagtaa actaagctat gtttaaatat
     4801 aatatataat aaaataagta aactaagtta tatttcagta taatatataa tgaaataagt
     4861 aaactaagtt atactccaat ataatatata atagaaacaa gtaaactaag ttatatttca
     4921 atatagcata taataaaaca agtaaaccag attctattta attagaagtt taaggtattg
     4981 tacttaaact tctaattgag atagaaataa aatggtttac ttgtttttat tatgagttta
     5041 ataaattaaa gcttatttta tttttattaa aaatttacta atcattgata tttattatat
     5101 ttccagtatt gatgtcaatt aagtttatat caagttcaag ctcatcctca tcatcagttt
     5161 ttatgatatc tataattgcg acagaatggc ttccatcttt tgggatagaa gtacttcctg
     5221 gatttattac tattaaatta tcatccatgt atagtttttt tacatgagta tgtcctaaaa
     5281 ctaatatgtc accacccatt ttctttgctt tgtcaataat ttcttcttct gattctatat
     5341 aaccatgatt caatataatt ctaatttcac caaattggct catgacataa ggactctgaa
     5401 taggatgttc tataaccatc tggtcaacat ctgcatcaca gttccctttt acaatcacaa
     5461 tgttttctaa tttatttaat gtctcaataa attttttagg attatatcct tctggaatat
     5521 catttctagg tccatgatat aagacatctc caccatgtaa taaaacatca caatcagata
     5581 atacatttaa cgctttttca aagtaaagta agctaccatg agtatcactc attattccta
     5641 ttttcatatt aaaaatcctc ctaagtacag tctataaaaa tttttcagat actctatgcc
     5701 aaaactcata gtttgacatt ctaagtaatt ttatttttgc atcagatata ctaactttta
     5761 tattttcgat ttgtctaaat ctgtgctcaa ctccatcaac gacaatcaat acagaatctt
     5821 caaatctata ttctggtgca atctttataa cagattcatt tgaacatatt atacttgatg
     5881 taaagcacct atatgcattg gtatttatcg gatgtaaagg tgtaatctgc ataagttcaa
     5941 gatttatatc aacaatacta cctccagcag aatagttata ggctgttgaa cctgtggaag
     6001 tagaaataat cataccatct ccactaaaat tttgtatatg tttattatca aggcttaaat
     6061 ttaggtgtat agtcctagac ttgtctcctc ttataacaac ctcatttaca gcaagcatat
     6121 tagaaccact agtagttgta tatacttccg cattaagaag tgacatttct tgaataatat
     6181 aatctttttt tgtataagct tcaataaagc tatcaatctt atctggtaaa atatcaggaa
     6241 aaaaccccag atgacctgta tttattccca ttatgggaat ctcaggaaaa tcgaaatctc
     6301 taactgttct taaaaaagag ccatcaccac caattgatat aataagctct gtgtctggat
     6361 aaatatctga atacacttca aagccagcat tgataagttt tctagttaag agttctttag
     6421 tctcaaggga cttatttaat tggtttgtat ttatagttat aattcttttc atatattcac
     6481 ctcttcatac tttgtattat aacatagttt tataattctt aatttataaa tttataaatg
     6541 acctttgtag tgaatgtgtt aaaatatgta taggtgggta taaaaaaatg cataagaggt
     6601 gaagatgtgt ttagcataag gaatatcaca aaaaaattag gaaaattcaa gttaaataat
     6661 ataaacttag agttaaagga aggggatatt gttgggatta taggaccaaa tggttcggga
     6721 aaaacgactt taataaaaat tataatgggg attattgatg cagatgaagg tgaaattgaa
     6781 ctttgtaatg aaactattga aaattctcca ataagcttta aaaacaatat tggttttgta
     6841 tatgattctt tacaatttta tccacattta aaggttaagg aatttagaaa aatagtttct
     6901 ttattttata agaattttga tagagaaaaa tttgatgaat accttaataa gtttgacata
     6961 gaagaaaata tgcatattga aaatttatct aaaggtcaat ctgagaagct tatgttatca
     7021 agcgcactta gtcataatgc taagttattg attttggatg aaccaactgc tggtatagac
     7081 ccgattgtaa gaactgaaat aatgcagtac ttacaagatt ttgtgaaaaa tggaagtagt
     7141 agtgtaataa tttctactca taatactgat aatttaatta aaattgctga ttatcttgtt
     7201 tttataaata gaggaaatca gatttttact gttaagaaag aattaataga acaagaatat
     7261 aagataatta gggcaaataa agcagagtta gaagcaatta aagaaagtat agttggtgtt
     7321 aaagagtata aatattataa tgaggcactt gttaaagttg gagatagctt gaaagtaaaa
     7381 agcctattga tagaaattga taagcataag gtcaaaaatc ctactataga agaactaatg
     7441 tattattatg taaatgaggt gagaggatgt tcaatttaat aagaaaagat ttaataatag
     7501 gaattagttc agatggtatc cgtaatttaa agtacatatt gctatttttt gtgttttatt
     7561 ttttccttaa ttcaatttca tattatacag taagtattgt tgttagttat ttgatattta
     7621 taaatacatt tgagtgtgat tatgaaaatg attcaaggat ttttataagg agtatgccag
     7681 ttagtataga agatatagtt tactcaaaat atttattagg tgtaggacta ataatttctg
     7741 taacaataat tgtgtcctta ctaagtaaat tgacatcact agtgttcttt agaaatatgg
     7801 ttttaaatga tgtatttttt tctgtaaata tatttttagc aattttgacg attttactgc
     7861 ctttaatttt taagtttgga tatggaaaaa tgaaagtttg tggttttata gtaagtattt
     7921 taatttactt tgtatatgga agtcttttga agatgattag tatgattgta tatcaagtaa
     7981 agcattttaa ttatagtaaa gttggaggag tatatctttc aaattatgta actgatatag
     8041 ctaatactaa gtatataaat ttatatagta tgacattttt aacaataata atttttataa
     8101 tatcaatgta tttttctatt aagatttcaa aaaagaataa gtttaattat taaaatttta
     8161 attaatatta tagcacaata gcacaaaata taaggagact aaaaatgaag aagtttataa
     8221 aagtttcatt ttttattttg gggattttta cactattcat agctataaat aaattagtat
     8281 atagagatat ggtaagtgtc aaagattatg aaataaatca tttagaggaa attgtttttg
     8341 attttgatag caggagaagt agagatatcg gtactattgt aagatttaaa ataagcaata
     8401 atagtaaata tagttataaa ttaaacagtg ctaaaatgaa gtttgaaaat tgtgtggaaa
     8461 ataaaaaggg aatgaataag tgttctgcat atgtaaatgt agatttattt aatgaaaaaa
     8521 attctataac tgaaagtact ctgaaatatg gaataaaacc aaataatcaa ggttatgttg
     8581 attttgtaat tccaaaagga ctaaattttg attataggta ctttaatgaa tctggtatga
     8641 gtgtagaata taaaggagaa tatattgtca atattccaat ggcaaaagga ctttatctag
     8701 tagttggaaa aaataatgat acatggaatg ctaatattat ggaataattt gaaaaataaa
     8761 tcaattatag atataattaa gaataatatg aaatttataa aaattcagac taggaggggt
     8821 atttaatgtc aataagtaat gtaagagagt attttaaaca atttggcaag gaagacagta
     8881 tattagaatt tgaacaatct agtgctactg tggaacttgc agctgaagca gctggggtta
     8941 ttccagcaag aatagctaag acactctcat ttaaaatagg agatgatgca attttaattg
     9001 tgacagctgg tgatgctaag attgataata agaagtataa ggctgaattt aattgtaagg
     9061 ctaaaatgtt gacaccagaa gaagtcttgg agtttactgg acatgctatt ggtggagtct
     9121 gtccatttgg tttaaaaaat tctataaaag tctatttaga tgattcaatg aagagatttg
     9181 atacagtatt tcctgcatgt ggcagtagta actctgcaat agaacttaca tgtgaagaaa
     9241 tggagaagtt ttctaagagt gaaaaatggg tagatgtttg taagaattgg taaaaaaata
     9301 tagtaaacta tagtaggaat tagtaaaaaa ctacctctgt atacaatcta tacagaggta
     9361 gttttttgtg taaatattta taaatctaag aggaaaatct aatttaaact aataatccaa
     9421 aataaagtta aaaaattctg attttttttc gaaacaataa aaaaatgaca aaaaagtgga
     9481 aaaaatgtaa taaatattgt taaaaaaata attagaaatt attgaaaaat tatcctttga
     9541 gtgttactat tatagatgta agatatttaa aaataaaaaa tagtcagata aaaatacgat
     9601 tatttagctc tattaaaata atttttatac gataaaaatc ttctgtacat ggctaaaaaa
     9661 cagatgtaca gacaatattt aatgtttaat ataccctaat ataaatatcg taaacaaatt
     9721 attttatctg tgaccagtgt gaaagaaatc ttattctaac ttgaaatttc acaaaattcc
     9781 aaaaagcgag atttttttta agtatagttg attttaaatt aacaatttat gattaaatta
     9841 atgtcataat tggttagtat aatcacatat aaatatagag cgtagtttga ttaaggttat
     9901 aaatttctcg acgtatattc aaatacctta ttatagatgt tgccgagatt ttaattaata
     9961 aatgaaaata aaatatttat aaaatactga ggaggctatt atggatttaa attctaaaaa
    10021 atatcagatg cttaaagagc tatatgtaag cttcgctgaa aatgaagtta aacctttagc
    10081 aacagaactt gatgaagaag aaagatttcc ttatgaaaca gtggaaaaaa tggcaaaagc
    10141 aggaatgatg ggtataccat atccaaaaga atatggtgga gaaggtggag acactgtagg
    10201 atatataatg gcagttgaag aattgtctag agtttgtggt actacaggag ttatattatc
    10261 agctcataca tctcttggct catggcctat atatcaatat ggtaatgaag aacaaaaaca
    10321 aaaattctta aaaccactag caagtggaga taaattagga gcatttggtc ttactgagcc
    10381 taatgctggt acagatgcgt ctggccaaca aacaactgct gttttagacg gggatgaata
    10441 catacttaat ggctcaaaaa tatttataac aaatgcaata gctggtgaca tatatgtagt
    10501 aatggcaatg actgataaat ctaaggggaa caaaggaata tcagcattta tagttgaaaa
    10561 aggaactcct gggtttagct ttggagttaa agaaaagaaa atgggtataa gaggttcagc
    10621 tactagtgaa ttaatatttg aggattgcag aatacctaaa gaaaatttac ttggaaaaga
    10681 aggtcaagga tttaagatag caatgtctac tcttgatggt ggtagaattg gtatagcagc
    10741 acaagcttta ggtttagcac aaggtgctct tgatgaaact gttaaatatg taaaagaaag
    10801 agtacaattt ggtagaccat tatcaaaatt ccaaaatacc caattccaat tagctgatat
    10861 ggaagttaaa gtacaagcgg ctagacacct tgtatatcaa gcagctataa ataaagactt
    10921 aggaaaacct tatggagtag aagcagcaat ggcaaaatta tttgcagctg aaacagctat
    10981 ggaagttact acgaaagctg tacaacttca tggaggatat ggatacactc gtgactatcc
    11041 agtagaaaga atgatgagag atgctaagat aactgaaata tatgaaggaa ctagtgaagt
    11101 tcaaagaatg gttatttcag gaaaattatt aaaatagata aatattaaaa tatacacaat
    11161 aggtcgatat taaaatagat atggaggaag gatttatgaa tatagtcgtt tgtataaaac
    11221 aagttccaga tacaacagaa gttaaactag atcctaatac aggtacttta attagagatg
    11281 gagtaccaag tataataaac cctgatgata aagcaggttt agaagaagct ataaaattaa
    11341 aagaagaaat gggtgctcat gtaactgtta taacaatggg acctcctcaa gcagatatgg
    11401 ctttaaaaga agctttagca atgggtgcag atagaggtat attattaaca gatagagcat
    11461 ttgcaggtgc tgatacttgg gcaacttcat cagcattagc aggagcatta aaaaatatag
    11521 attttgatat tataatagct ggaagacagg cgatagatgg agatactgca caagttggac
    11581 ctcaaatagc tgaacattta aatcttccat caataacata tgctgaagaa ataaaaactg
    11641 aaggtgaata tgtattagta aaaagacaat ttgaagattg ttgccatgac ttaaaagtta
    11701 aaatgccatg ccttataaca actcttaaag atatgaacac accaagatac atgaaagttg
    11761 gaagaatata tgatgctttc gaaaatgatg tagtagaaac atggactgta aaagatatag
    11821 aagttgaccc ttctaattta ggtcttaaag gttctccaac tagtgtattt aaatcattta
    11881 caaaatcagt taaaccagct ggtacaatat acaatgaaga tgcgaaaaca tcagctggaa
    11941 ttatcataga taaattaaaa gagaagtata tcatataatt taagggggga taaagaatgg
    12001 gtaacgtttt agtagtaata gaacaaagag aaaatgtaat tcaaactgtt tctttagaat
    12061 tactaggaaa ggctacagaa atagcaaaag attatgatac aaaagtttct gcattacttt
    12121 taggtagtaa ggtagaaggt ttaatagata cattagcaca ctatggtgca gatgaggtaa
    12181 tagtagtaga tgatgaagct ttagcagtgt atacaactga accatataca aaagcagctt
    12241 atgaagcaat aaaagcagct gaccctatag ttgtattatt tggtgcaact tcaataggta
    12301 gagatttagc gcctagagtt tctgctagaa tacatacagg tcttactgct gactgtacag
    12361 gtcttgcagt agctgaagat acaaaattat tattaatgac aagacctgcc tttggtggaa
    12421 atataatggc aacaatagtt tgtaaagatt tcagacctca aatgtctaca gttagaccag
    12481 gggttatgaa gaaaaatgaa cctgatgaaa ctaaagaagc tgtaattaac cgtttcaagg
    12541 tagaatttaa tgatgctgat aaattagttc aagttgtaca agtaataaaa gaagctaaaa
    12601 aacaagttaa aatagaagat gctaagatat tagtttctgc tggacgtgga atgggtggaa
    12661 aagaaaactt agacatactt tatgaattag ctgaaattat aggtggagaa gtttctggtt
    12721 ctcgtgccac tatagatgca ggttggttag ataaagcaag acaagttggt caaactggta
    12781 aaactgtaag accagacctt tatatagcat gtggtatatc tggagcaata caacatatag
    12841 ctggtatgga agatgctgag tttatagttg ctataaataa aaatccagaa gctccaatat
    12901 ttaaatatgc tgatgttggt atagttggag atgttcataa agtgcttcca gaacttatca
    12961 gtcagttaag tgttgcaaaa gaaaaaggtg aagttttagc taactaattt cttggggagg
    13021 gtattatgag tacaagtgat gttaaagttt atgagaatgt agctgttgaa gtagatggaa
    13081 atatatgtac agtgaaaatg aatagaccta aagcccttaa tgcaataaat tcaaagactt
    13141 tagaagaact ttatgaagta tttgtagata ttaataatga tgaaactatt gatgttgtaa
    13201 tattgacagg ggaaggaaag gcatttgtag ctggagcaga tattgcatac atgaaagatt
    13261 tagatgctgt agctgctaaa gattttagta tcttaggagc aaaagctttt ggagaaatag
    13321 aaaatagtaa aaaagtagtg atagctgctg taaacggatt tgctttaggt ggaggatgtg
    13381 aacttgcaat ggcatgtgat ataagaattg catctgctaa agctaaattt ggtcagccag
    13441 aagtaactct tggaataact ccaggatatg gaggaactca aagacttaca agattggttg
    13501 gaatggcaaa agcaaaagaa ttaatcttta caggtcaagt tataaaagct gatgaagctg
    13561 aaaaaatagg gctagtaaat agagtcgttg agccagacat tttaatagaa gaagttgaga
    13621 aattagctaa gataatagct aaaaatgctc agcttgcagt tagatactct aaagaagcaa
    13681 tacaacttgg tgctcaaact gatataaata ctggaataga tatagaatct aatttatttg
    13741 gtctttgttt ttcaactaaa gaccaaaaag aaggaatgtc agctttcgtt gaaaagagag
    13801 aagctaactt tataaaaggg taaaaatcta attaaaaata tatttgctgt taactagatt
    13861 aaatagtatt ttaatctagt taacagaata taaatactaa aataacagga ggttataact
    13921 atgaaattag ctgtaatagg tagtggaact atgggaagtg gtattgtaca aacttttgca
    13981 agttgtggac atgatgtatg tttaaagagt agaactcaag gtgctataga taaatgttta
    14041 gctttattag ataaaaattt aactaagtta gttactaagg gaaaaatgga tgaagctaca
    14101 aaagcagaaa tattaagtca tgttagttca actactaatt atgaagattt aaaagatatg
    14161 gatttaataa tagaagcatc tgtagaagac atgaatataa agaaagatgt tttcaagtta
    14221 ctagatgaat tatgtaaaga agatactatc ttggcaacaa atacttcatc attatctata
    14281 acagaaatag cttcttctac taagagacca gataaagtta taggaatgca tttctttaat
    14341 ccagttccta tgatgaaatt agttgaagtt ataagtggtc agttaacatc aaaagttact
    14401 tttgatacag tatttgaatt atctaagagt atcaataaag taccagtaga tgtatctgaa
    14461 tctcctggat ttgtagtaaa tagaatactt atacctatga taaatgaagc tgttggtata
    14521 tatgcagatg gtgttgcaag taaagaagaa atagatgaag ctatgaaatt aggagcaaac
    14581 catccaatgg gaccactagc attaggtgat ttaatcggat tagatgttgt tttagctata
    14641 atgaacgttt tatatactga atttggagat actaaatata gacctcatcc acttttagct
    14701 aaaatggtta gagctaatca attaggaaga aaaactaaga taggattcta tgattataat
    14761 aaataagaat ttgggaatta aaagtttaaa taaaattgtt taaaaaacaa tttcggatat
    14821 atgaaaaatc taatttaatg ggggtaatga atatgagaga agtagtaatt gccagtgcag
    14881 ctagaacagc agtaggaagt tttggaggag catttaaatc agtttcagcg gtagagttag
    14941 gggtaacagc agctaaagaa gctataaaaa gagctaacat aactccagat atgatagatg
    15001 aatctctttt agggggagta cttacagcag gtcttggaca aaatatagca agacaaatag
    15061 cattaggagc aggaatacca gtagaaaaac cagctatgac tataaatata gtttgtggtt
    15121 ctggattaag atctgtttca atggcatctc aacttatagc attaggtgat gctgatataa
    15181 tgttagttgg tggagctgaa aatatgagta tgtctcctta tttagtacca agtgcgagat
    15241 atggtgcaag aatgggtgat gctgcttttg ttgattcaat gataaaagat ggattatcag
    15301 acatatttaa taactatcac atgggtatta ctgctgaaaa catagcagag caatggaata
    15361 taactagaga agaacaagat gaattagctc ttgcaagtca aaataaagct gaaaaagctc
    15421 aagctgaagg aaaatttgat gaagaaatag ttcctgttgt tataaaagga agaaaaggtg
    15481 acactgtagt agataaagat gaatatatta agcctggcac tacaatggaa aaacttgcta
    15541 agttaagacc tgcatttaaa aaagatggaa cagttactgc tggtaatgca tcaggaataa
    15601 atgatggtgc tgctatgcta gtagtaatgg ctaaagaaaa agctgaagaa ctaggaatag
    15661 agcctcttgc aactatagtt tcttatggaa cagctggtgt tgaccctaaa ataatgggat
    15721 atggaccagt tccagcaact aaaaaagctt tagaagctgc taatatgact attgaagata
    15781 tagatttagt tgaagctaat gaggcatttg ctgcccaatc tgtagctgta ataagagact
    15841 taaatataga tatgaataaa gttaatgtta atggtggagc aatagctata ggacatccaa
    15901 taggatgctc aggagcaaga atacttacta cacttttata tgaaatgaag agaagagatg
    15961 ctaaaactgg tcttgctaca ctttgtatag gtggtggaat gggaactact ttaatagtta
    16021 agagatagtt ttagattata atatttacaa attaaatatt taattatgaa tttaacctgt
    16081 atgaataact atttgttatt cttacaggtt tttatagtta aaaataatta ttatctatta
    16141 aacaaaaata gtgtaaaata tataatatca tgattttgaa gatataaaaa gcaggaagat
    16201 ataaaagaaa gtaggtaaaa gtttgtttaa aaaagagaat caaagatata atcttatatc
    16261 gtatacaaat gaagaagaaa tgactttaaa agaagtttta ttggacaagc taaatttctc
    16321 agttaggtca ttatcaaaaa tgaagaagga aaagagtgtt ttagtaaatg gagtatataa
    16381 aaaaccaagt ttaaaggtgt atagtggtga tttaatagaa gtaaaaatag acgaggaaaa
    16441 agcaaatttt gaacctcaag atttaaattt acagataatt tatgatgatt ttgatataat
    16501 tatggtgaat aaacctccat ttatggtagt tcacccaaca aaaagccact atgataaaac
    16561 aatagcaaat ggtattagtt actatataga taatcaaaaa gaaaacgtaa aaataagatt
    16621 tgtaaatagg ttagatatga atacttcagg gttagttata gtagcaaaaa atgcttatgc
    16681 acatcatact ttatctacag caatgagtga aaataaagtt gaaaaaaagt atataacagt
    16741 agttgatgga attataaaag aaaatgaggg aactatagat gagccaattt atagacctac
    16801 agaagattca ataaagagga taatagatga aagaggacag tcatctgtta ctcactataa
    16861 agtaatagaa agactagaaa atgcaactgt attagaagta agcttagaaa ctggtagaac
    16921 acatcaaata agagtacata tggctcatat aggtcatgga ataataggtg atgagttgta
    16981 tggttatgta gatgaagagc taataaatag gcaagcactt catgcataca agctagagtt
    17041 tgaacaacca agaacaaaag aaaaattgaa atttaaagca gatataccag aggatatgaa
    17101 agagttaata tcgaaattaa gataatgggg tgatatatat gataatacat aaatttataa
    17161 tacatgtttt ggacaaaaat agtgatgttc caatattaaa tgactttgaa ggcaaagtta
    17221 atcaagaagt agatggtttt ttccagaaag ctataaaaag aattgcaaaa gatgaggatt
    17281 taagaaaagg tgtttttaaa gattataatg acaatttaat taaaaactgt tgtgaacaaa
    17341 taatatatga tgaaagtact tttttgaaaa attctaaaga aattgcatct tacttgtttg
    17401 acgttatgaa aattaatgct gcactagaat cttgtgattt ggcaatttgc ttatacacta
    17461 ttaaagatga aaagagtgta gcaatactga aattagatta taaaaagttg tacactcatt
    17521 caattgaatt tgtggatgat aaatttaata ttcaaatggt ttcaaatgaa attggtatcc
    17581 cagagacttt aagacaaaag caaggagctt tgattagttt aagtggtata aatgatgagt
    17641 ttcatctaag gcttttagat aaggatgctg aaaaagaagg gtcagaatct aagtttgtaa
    17701 cagaattttt aaatgctaaa aaaatagatg atgataagta caagaccaag gtatttaaaa
    17761 atacagctga aaattggata actaatgctc ttagtaatga tataaagcaa gctgaagatg
    17821 taagaagtat attaaattat acactgaagg aaaaacatga agttgatata aatgactttg
    17881 ttgataattc aattaaagat gatgagttaa aggatagctt taaagagcat atggaagaaa
    17941 aaggtcttga tgaaagtttt agtatagata aaaaatgggt tgagaaaaag cttaaaaaaa
    18001 gaagtataaa aacggataat ggttttgaca taaaagggaa tctaactgat tttgaagacc
    18061 caatgaagta tactgtaaag caaaatcaag atggaactat agatataata ataaagaatg
    18121 ttacatttta tgaagaaaag taatttatat acttagtata taaattaaat ataagagcgt
    18181 gtattttata tattgtaaat aaatgtaatc tagtctgtgc gaactctaat ataatttatt
    18241 atgtagaagt ttacacagac tatttatatt tgtagacaaa acgatactat ttgttttctt
    18301 cgatatattt acatatatca ccaatacatt taaagttctc agcttcctcg tctggtattt
    18361 ctattccaaa ttcatcttca agggccatta taatttcaac agcatctaat gaatcagctt
    18421 ctaagtcgtc cattaaagat gcttccatag ttatctcatc taaattgtct acccctaatt
    18481 gttctgctat tatttctttt attttctcaa acattttaag cctcctaaag cagttttaat
    18541 taattttaat gttagtttaa tataatatca agaatttttc aatatggaat ctataaaaaa
    18601 taataaaatt ttataaatgt agtaataaag tattatttga tgaataaact ttattgataa
    18661 caaatataac ttaggaggaa atgctatgaa atatgtagga ctattactaa cttcagtagg
    18721 aatgttttta cttatagcag taaattttta ttataattca ataactttag atatgcaacg
    18781 tatagaggat tatgtaatgg agaccaattt aatccttgaa gatgtagctg aaaaggagag
    18841 ttatgtatct aatgaaaaag aagactacat atcaaggtta atgcatgtaa agaaaggaat
    18901 agaaaattca aaaacatcct tcttgataga aagatataag gagtacaaaa taaaatcaat
    18961 agaaagttta atctacacta tatcagagga gaaaaaagat tatctggatg aagttgatag
    19021 atacaataaa cttggtgaaa aagaaataaa taaactaatc aataaaaact ttttagaagt
    19081 aacttatctg tctattacta catatattta attaaagaga caaaacttag tctcttaatg
    19141 attcaaggag gattagttat gacaaaatta gaagacaata tggaacgttt ctttggagga
    19201 tgcgaaggat tttttggtaa taaaatgttg ataataatag ttatagtatt cttactatta
    19261 tgcacagaca ttttagaaga cttattatgc gatgacaata tatggatatg ggttatatta
    19321 atagtattgt tattatttaa cttcgatgat ggttgttgtt gctaaaaaat attgattatt
    19381 aaataggtaa aaccagtaac ttatacaagt tatggtttta ccttttttag ttcaaattaa
    19441 aaaatttaaa aaaatagtaa aaatacatta gcaaaatgga aaccaaatgc atagtatatg
    19501 ttaggagcga aaagctcaac aaaatatcaa caggaggtaa cgtacaatgt tagatagatt
    19561 ctttggagaa gaaggatgtt ttggtggagg aggatggtgg ataatagtac tattcttcct
    19621 attcttagct tttggagata gctgggcaga atttgacata atggcatgga taccattcct
    19681 aatagtttta ttaatacttt gctgctgtgg tggatgctta gaataagaac acagttatta
    19741 aaaaaaggag ggctttgtta tgttagatag attttttgga gaagaaggat gctttggtgg
    19801 aggaggatgg tggataatag tactattctt cctattctta gcttttgaag attgctggag
    19861 agacattgac ataatgtcat ggataccttt cttaatatta ttgctaataa cttgttcatg
    19921 tggtggattc tttgatggtg aagtaggttg cggctgctaa tacttaaatc attagaataa
    19981 aaaaatgctg gtattttata ccagtatttt tttattttat tttttaatat gatttaaatt
    20041 aagaatgaat attattaaat ttgttgaata tagggtataa tataaaatat aatgtattta
    20101 aatgtacttg cttttatggt aaaataaaaa cttatataaa tgtagttaaa ataggaacct
    20161 tcaaaaattt ggttcagttt tagataaatt tagtaaaata aggaggatga agatgaaagg
    20221 caatataacg ataaaagatg ttgctaaaca agcaggagtg tcaatatcta ctgtatctag
    20281 agttataaat gattcaaaac ctgtaactga tgaagtcaaa caaaaagttt tagaggttat
    20341 aaaagagact ggatatatac caaatccact tgctagaagc ttagtaacaa agaagagtca
    20401 attaataggg gtaatagttc cagaagtttc agattctttt gttaatgagg tgttaaatgg
    20461 gatagaagaa gttgctaaaa tgtatgacta tgatattctt ttagcgaata catactctga
    20521 taaggaacaa gaacttaaga gtataaatct attgagagca aaacaagtgg aaggtatagt
    20581 tatgatttca tggatagttg aacaagaaca tatcaactat atacaaaatt gtggaatacc
    20641 agcgacatat ataagtaaaa ctgctagaaa ttatgatata tatacagtaa gtactagcaa
    20701 cgaagaagct acttttgata tgacagagca tcttataaag aaaggtcatg aaaagatagc
    20761 ttttataatg acgagtaaag atgatactgt tttagaaatg gaaagacttg ctggttatga
    20821 gaaagcactt tcaaataaca atatagaatt agacaagagt ttgattaagt atggtggaac
    20881 tgattatgag agtggataca atagtatgaa agaactatta gatgatggaa taatacctca
    20941 tgcggctttt gtaacaggtg atgaggctgc cataggtgct ataaatgcta tatgtgatgc
    21001 tggatataag gttccagaag acatatctgt tgcaggattt aatgatgtta agatagctag
    21061 aatgtataga cctaaactta ctacagtata tcaacctcta tacgatatgg gagcagtagc
    21121 aataagaatg gttataaaat taataaataa ggaattaatt gaaaataaga aaatagaatt
    21181 accttataga attgttgata gagaaagtgt tacagaaaga aaaaaataaa actattaaaa
    21241 tcaatcaggt agtgcctaag gcactacctg attttttatg tcaataatat caaatttaat
    21301 aatagattaa ctaaaaataa ttatctaatt acttaaatag tttattttta tctactcatg
    21361 agggttagac tttttagttt tcttaaataa acctttagat tttttttgtt gaccacctgg
    21421 tgtatttttt ggtgcaggtg aatttgattt acctttagta ggtttagcct tcttagtttt
    21481 agctggttta gtatctcttt gattttctgc atctgagatt ttttccatta tattatctag
    21541 ttttttgcgt tgattttcat ctaaaaatgc tttgaatttt gatactactt catctcttcc
    21601 atctaagttc ttacctattt ttataagttc ctccataagt tcattttctg attttccttt
    21661 gtaactatca gccatctttt ctattttatc cttgtcaata tttttttgtt tagccatttt
    21721 ttctaatgac tctgtatcta attttttcat aaaaaaaccc ctttctataa atatatattg
    21781 aattatattc atactattta tatatagaaa taatattgaa gtggtgaatt gtgagtgata
    21841 tataatataa ataaaaattc ttatagataa tatatatgca ctgagcttta aaaatggaac
    21901 attaaaatat gaaaaacata ctttaatata gggcaattat ataatataag ggggaattgt
    21961 cttgaataac ttactatttt tgattggagt gattgcattg agtaatggta atatctctat
    22021 atttgatgat aaaaataaat caaaaggaaa taatagagtt agaaaaaaca aaaaaaatgc
    22081 aaatgataaa ctttcacagt ctacacatgg caatttaagg tttgatgcaa atgatataaa
    22141 aagaggttta aggctcatgg atttaagtga agaagattta gaaatgggaa tggaaataat
    22201 aacaagaact aaaaaataca tgtcaagaga tgaaagaaaa atactaataa aaatagaaag
    22261 tgttttagat ttagttagag gaataaaaaa attaaataat atagatatgg tagatacaga
    22321 agatgaaacg gattttttca gaaaaatgga tagtgatgat aaaaagaata tgatgataaa
    22381 ggaaattata gatgtattcc cagaaaaaag aaaaaattca gttgaaaaag ctataggaat
    22441 gaaaaagaag atagatttat ttgcagaatt atttttacca gatgactttg gtgaaggtgg
    22501 atttagtttg agctctttgg caaatataaa caatcttggt agtatgaata atctcaaatt
    22561 gttaggaagt cttttaagag gtgatgatag taataatgat gatgaagaca ataatgatga
    22621 gttaaattat gaagacgaag aattagattg tgaagacaaa gaattggatg atgatgagtt
    22681 aacagatgaa ggtgaaatgg aggataatga agatgaatta gtagaagata agaacacagg
    22741 ctatgaaaat atagaaaatg atgaagatat agtatacgat gaggaactat acaacattaa
    22801 tgagcaagaa tccgaataca attataatga aaaaaatact aaaactagag ctaagaaaaa
    22861 acgataatta actaaataca taaagaaaaa aggaagaaaa agtaatgata gaataagatt
    22921 atctcaatta ctatataaaa ccactttaaa aaattcaaaa tttattatat aataataata
    22981 tgaaatcctg aaacatacga taaggctttt ttaaattcaa cctacaaatg aaatacggga
    23041 gaccgtgtct ggtaaattat aacatgccta gttagtttgg acgttaaagg ttactggcaa
    23101 gtcacccacc tgggagtgcc tagggtgtga atttacttag ccaccggtgt ttcgggacaa
    23161 aaaaagtgct actatttcaa atagtagtac tttttttatt aatatgcatt tttctactaa
    23221 atacgcctaa ttattgataa attcaaaaag caagtaacaa ttaagattat aaaagcatag
    23281 tattaattag gcttcaaaaa gccaaagact taataagaat cgcttacagg gagggcaatg
    23341 aaaaatgcaa gattataaaa aaaataaaag aagaatgatg aatcagccaa tgtctacaat
    23401 gaatgaagaa gaagtgtata cagatgaaat aaattcagaa gacatgagag ggtttaaaaa
    23461 atcacaccat cataatggat gtaatactga taataagtgt gagtgccatg atgagtgtaa
    23521 tccatgtaac ccatgtaatc catgtaaacc taacccatgc aatccatgca aacctaatcc
    23581 atgtgatgac aaatgtgaat gccatgacaa gtgtaaatgt gattgtgaac catgtgaaat
    23641 ggattcagat gaatgttttg aaaacaaatg tggaccagaa tgttgtaatc cgatatctcc
    23701 aagaaacttc tctgtatcaa atgcagtgcc atttgcaata gaggctaata gaatatttga
    23761 tactatgcaa ttccaaacat ttacagatgc aacaggtcca aatggagaac cattaacttt
    23821 tgaaacagaa gtagtagaag tatttggttc aattccaagt gcaggtcaag caagtgtaac
    23881 tatagaaaaa atatgcttaa gtaatgatgg aatagttata gacacaggaa tgacaacttt
    23941 agaagatttc gatttagacc cattaggaga tatagtagga agaaactgtg aaacaacttt
    24001 tgaatttgca gtttgtggag aaagaaacgc tgagtgctgt agacaaggaa aaggcaaatc
    24061 agtagcttat aaacaaagag gattaactgt agcagttcgt aatttagtac tagagctaag
    24121 aggtagatgt ggatgtacag agttcgttgc attagctttc ccagcagtta gagcaggagg
    24181 tggatgtaag agaagagttg attatgtaga atttactttt aacacacttt cagcaccaat
    24241 atgcttgcca gctgacggaa gagctgttac tttaagacaa gaatatcaaa ctaacttaac
    24301 tgtagattgt ataggaaaat ctatattaaa attagaatgc aacgaatgtt gtgaaccttt
    24361 ctatgaatta attataccaa atgatataga tttagtactt tgcttacaag aaacagttag
    24421 cacattaata agtgaacaaa tagtagtttt agcatcacca aatccaatcc aaccaagact
    24481 tgttgatact ttctctaaag tatgtgattt ttcgcaatgt ggacctaatc atggaagtgg
    24541 aaagccaagt tgccacagat agataggtaa gatatataga cagtttaaat tataaataaa
    24601 aatcatctaa ggaaggctac caaagtgtat aatttacatt ggtagccttc acgtttttat
    24661 aactagcgta tagattttag tgatttaaaa agcactatag tatgtaatag acaagtaaag
    24721 attgatacta tcgtcattgt gtatatgtat gcataaatat taagtcctgg aattggaaga
    24781 aatacatata aagctattag ttgaattaac atgccagtaa tagtatttat acttgaagct
    24841 aattcttttc ttattgaatg taaaatgcca gatagagttt gatttaggga cataaatagt
    24901 ggaactaaaa acatagcttt tagatattct cctgcaagtg tatttttaaa tactaatata
    24961 cataaatctt ttccaaagaa ataaaaaaat attgatgata gtatgcctac aaataaagta
    25021 agaagtatgg agtatttgat ttttttaatt acactcttac gctttcttag agccatttcc
    25081 tgtgaaatag ttggtattaa atttacaata agcgctgaac caacagtaaa aggtaaaaat
    25141 ataaagggca ttaccatccc actgacaata ccatacatac ttaaagattg ttgataagtc
    25201 attcctgata atgctaatct tgatggtatc atcatagaac ttatagattg caaaagtatg
    25261 tttgacattc tattacaagt tatgggaata gacattttta atgtttccat agaagaatta
    25321 taaaaatctt ttatgcttat aatataccta ttgtcaaatg atgaatctcg ccataagcaa
    25381 ataagcataa atataatatt gctcaactca ccaatagata tacctaatag agctatataa
    25441 caattcatag atttattatt tatgtacata acaagtaaaa aaacaaataa tattttacca
    25501 atttgttcaa tgatttgtcc aatagcaggg atttttacat tctttatgcc atagtaatat
    25561 cctcttagta cgtttgaaag agttattata actatagcag gacaaacagc tagtataaat
    25621 agatttaatt tagcatcttt taaaaattta agtgataaaa aagaactatt gaaagatgca
    25681 actatagata taattagtgc tacgaaaaat gatatatata aagttgatat aaatagagca
    25741 ttagtattgt gtctatcgtt taaagctttt ctctttgcaa ctagacaact aagtgcagta
    25801 ggtatacctg ttgttgtaac agctaagcaa atcatcaaaa agttaaaaat catatgatag
    25861 atacctaaac ctgtttcacc tagtgctctt gataagaata ttttatataa aaaaccaaat
    25921 attcttacaa taaaattgga tataaataaa ataactgttg atagtactaa ataaggtact
    25981 ttcaaaaaaa tcacctcctt atcttttaaa tatattcaca aggaggtg
//
