LOCUS       FN545816               29137 bp    DNA     linear   BCT 27-FEB-2015
DEFINITION  Clostridium difficile R20291 complete genome.
ACCESSION   FN545816
VERSION     FN545816.1
KEYWORDS    .
SOURCE      Clostridioides difficile R20291 (Clostridium difficile R20291)
  ORGANISM  Clostridioides difficile R20291
            Bacteria; Firmicutes; Clostridia; Clostridiales;
            Peptostreptococcaceae; Clostridioides.
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-32bee55(changed)
            Run date     :: 2021-04-09 12:09:52
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 427492
            Orig. end    :: 456629
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..29137
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[437492:446629]"
                     /cutoff="10000"
                     /detection_rule="(minimum(3, [Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, CoA_transf_3, ETF,
                     ETF_alpha, FGGY_C, HCDH, Hacid_dh_C, Lactoyl-CoA1,
                     Lactoyl-CoA2, MreB_Mbl, NAD_binding_2, Peptidase_M22,
                     UDPG_MGDP_dh_N]) and minimum(1, [HleuD1, HleuD2, HleuS1,
                     HleuS2]))"
                     /neighbourhood="10000"
                     /product="Leucine_reduction"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..19137
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(3, [Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, CoA_transf_3, ETF,
                     ETF_alpha, FGGY_C, HCDH, Hacid_dh_C, Lactoyl-CoA1,
                     Lactoyl-CoA2, MreB_Mbl, NAD_binding_2, Peptidase_M22,
                     UDPG_MGDP_dh_N]) and minimum(1, [HleuD1, HleuD2, HleuS1,
                     HleuS2]))"
                     /neighbourhood="10000"
                     /product="Leucine_reduction"
                     /protocluster_number="1"
     cand_cluster    1..29137
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(minimum(3, [Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     CoA_transf_3, ETF, ETF_alpha, FGGY_C, HCDH, Hacid_dh_C,
                     Lactoyl-CoA1, Lactoyl-CoA2, MreB_Mbl, NAD_binding_2,
                     Peptidase_M22, UDPG_MGDP_dh_N]) and minimum(1, [HleuD1,
                     HleuD2, HleuS1, HleuS2]))"
                     /kind="single"
                     /product="Leucine_reduction"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..29137
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Leucine_reduction"
                     /region_number="3"
                     /rules="(minimum(3, [Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, CoA_transf_3, ETF,
                     ETF_alpha, FGGY_C, HCDH, Hacid_dh_C, Lactoyl-CoA1,
                     Lactoyl-CoA2, MreB_Mbl, NAD_binding_2, Peptidase_M22,
                     UDPG_MGDP_dh_N]) and minimum(1, [HleuD1, HleuD2, HleuS1,
                     HleuS2]))"
                     /tool="gutsmash"
     gene            974..1837
                     /locus_tag="CDR20291_0358"
     CDS             974..1837
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0358"
                     /db_xref="EnsemblGenomes-Tr:CBE02084"
                     /db_xref="GOA:C9YIG4"
                     /db_xref="InterPro:IPR000620"
                     /db_xref="UniProtKB/TrEMBL:C9YIG4"
                     /locus_tag="CDR20291_0358"
                     /product="putative membrane protein"
                     /protein_id="CBE02084.1"
                     /transl_table=11
                     /translation="MILSYFALLIRVVLLAFERVVVRLLGDEEGDIYKNIASSFLFFFI
                     GGVCLLPFSIMDRVSDWSFLIPCYISSLVYSIGSVAYVTSLATGEVSLVTPINSLNSLF
                     LLLLSVIFLGEGLSLAKVAGIIIMIGGVFILKKVSSFLKNVSVIFNNLPCRLMFLYIFL
                     QSVGRVLDKAFFVQVSPILYSTILYFFVGLNLFIFLAFKKKQKIICEIFSNKKGLSILS
                     GAINGYSYLALLIALNNLELSIAEPFSQVSMIITLILAHFIFKENIKEKIPGSILILIG
                     GWLLLL"
     gene            2084..3946
                     /gene="bglF"
                     /locus_tag="CDR20291_0359"
     CDS             2084..3946
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0359"
                     /db_xref="EnsemblGenomes-Tr:CBE02086"
                     /db_xref="GOA:C9YIG5"
                     /db_xref="InterPro:IPR001127"
                     /db_xref="InterPro:IPR001996"
                     /db_xref="InterPro:IPR003352"
                     /db_xref="InterPro:IPR011055"
                     /db_xref="InterPro:IPR011297"
                     /db_xref="InterPro:IPR013013"
                     /db_xref="InterPro:IPR018113"
                     /db_xref="UniProtKB/TrEMBL:C9YIG5"
                     /gene="bglF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTS_EIIC"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CDR20291_0359"
                     /product="PTS system, beta-glucoside-specific IIabc
                     component"
                     /protein_id="CBE02086.1"
                     /sec_met_domain="PTS_EIIC (E-value: 1.3e-21, bitscore:
                     74.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYKKTAIDIIEQVGGSKNILALEHCSTRLRFKLIDRSKVNQDAL
                     KKVQGVMSIVNGAQFQVVIGNSVVDVYDEILKVCPLDTNDSTVKTEEKINLGTRFIEFI
                     INIFQPLIFAIAGAGILKSLLMLLAMFNILKSDSTIYTLLVAISDATFYFLPLMVAVTT
                     ANVLKCNRLVAIAAVGYLLLPATTTALSEGVELFGFTIPNIAYNAQVFPAILCVSFLAT
                     MEKIFNKYSPKPIRTFFVPMMSLAITVPITLTILGPLGYNVGTIFTTIILFLYNKMGFL
                     VVGLLAAFLPFMVATGMHKALIPYSINTIGKLGYEALYMTSSLAHNISESGACFAVALR
                     TKDETLKQTALSAGISALMGITEPALYGITLQHKRAMLGVVFSSAISGTFLGLFAVKGF
                     VIVGPGLASMSMFIDPNNGNNLIFASIGFVIAILGSFIITLIIWKEDTNTVESSIGDVV
                     EEELEEEKEVNILVTPVEGKVIDLSKVNDELFASKTLGDGVAIIPTNGNLYAPCDSEVV
                     MLFETKHAIGLRTKNGAEILIHIGINTVSMNGDGFKTFVKTGDNVKEGDLLIQFDLDKI
                     SHANLDSTVMIVNNNGADYAYKVLNQSYGNVKKGSILFDVKGGI"
     gene            3949..5415
                     /gene="bglA"
                     /locus_tag="CDR20291_0360"
     CDS             3949..5415
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0360"
                     /db_xref="EnsemblGenomes-Tr:CBE02087"
                     /db_xref="GOA:C9YIG6"
                     /db_xref="InterPro:IPR001360"
                     /db_xref="InterPro:IPR013781"
                     /db_xref="InterPro:IPR017853"
                     /db_xref="InterPro:IPR018120"
                     /db_xref="UniProtKB/TrEMBL:C9YIG6"
                     /gene="bglA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CDR20291_0360"
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="CBE02087.1"
                     /sec_met_domain="Glyco_hydro_1 (E-value: 2.3e-119,
                     bitscore: 396.4, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKFPEGFLWGGATAANQFEGGWNLGGKGWSVSDVAKAHFDADVK
                     DYKSNNEITTKDIEEGLAHPEDEVNYPKRHGSDFYHHYKEDIALMAEMGFKTYRMSIAW
                     SRIFPNGDDKEPNEEGLQFYDDVFDELISYGIEPLVTMSHYEPPLNIVLNYDGWYSRQV
                     INMFVRYVETICERYKNKVKYWLTFNEVDSMIRHPYTTGGLVRDRFKDKNFEEVIFQAM
                     HHQFVASALATKICHEIIPNSKVGCMLTKLTYYPYTCRPEDVLATQQKMRSIYAYSDTQ
                     VFGEYPVYLLSYFKNNNIQIAKEEHDDEIMKKYPVDFISFSYYMSSCEAADTTGLDITP
                     GNTLLAVKNPYLEMSEWGWQIDSIGLRISLIELYDRYRKPLFIVENGLGAKDILTEDKK
                     VHDQYRINYLKEHFKCMLDAIIEDGVELWGYTSWGCIDLVSESTKQMSKRYGYIYVDAD
                     DYGKGTYNRYKKDSFYWYKKVIENNSIDFK"
     gene            5439..6275
                     /gene="bglG"
                     /locus_tag="CDR20291_0361"
     CDS             5439..6275
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0361"
                     /db_xref="EnsemblGenomes-Tr:CBE02089"
                     /db_xref="GOA:C9YIG7"
                     /db_xref="InterPro:IPR004341"
                     /db_xref="InterPro:IPR011608"
                     /db_xref="UniProtKB/TrEMBL:C9YIG7"
                     /gene="bglG"
                     /locus_tag="CDR20291_0361"
                     /product="beta-glucoside bgl operon transcription
                     antiterminator"
                     /protein_id="CBE02089.1"
                     /transl_table=11
                     /translation="MNYIIKKVLNSSVVLVHDAKYNEFILLGKGIGYGKKTGEYICGSN
                     DNQMFVPVENTKSKKFLELMDDIPVDILKITQEIIVEAEKLLNSSFNKNLYLILADHFN
                     FAIERMRKGIKITNRVFWEIKNYYPNEFKVGMVAIYMVEERLGIQLPEEEAANIAFHFA
                     NAMASDGNSYDTIKYAKVIGEIINIFVFSLNRTLDKKSMHYMRFITHIKFFVERFFSDS
                     MLSSGDDLLFNQMKRSNPKEMLIALKVRDFLEKKYGKKLTNEEIAFLVVHIARVKQ"
     gene            6841..8424
                     /locus_tag="CDR20291_0362"
     CDS             6841..8424
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0362"
                     /db_xref="EnsemblGenomes-Tr:CBE02091"
                     /db_xref="GOA:C9YIG8"
                     /db_xref="InterPro:IPR000583"
                     /db_xref="InterPro:IPR001962"
                     /db_xref="InterPro:IPR006426"
                     /db_xref="InterPro:IPR014729"
                     /db_xref="InterPro:IPR017932"
                     /db_xref="InterPro:IPR029055"
                     /db_xref="UniProtKB/TrEMBL:C9YIG8"
                     /locus_tag="CDR20291_0362"
                     /product="asparagine synthetase"
                     /protein_id="CBE02091.1"
                     /transl_table=11
                     /translation="MINLEEKYLTRKDTYMIKILEYNGHIRNWKVLCEELGIDSSLCRD
                     ERERAILVEAYKTWGYDMANHMHGMFAFALWDTVEKKLFCLRDQFGVKPFYYYETENGK
                     LLYGSSIRKIMEQPGFVKELNEDMLQIYMSFTYVAGENTFFRGVKKLMPGHYLVYQNKT
                     VCIGRYWKPEFHPDHSKSIEEWTDEIHTTLQKIMPEVKSENETAELFLSGGVDSSYILA
                     MSDIEKTGSCGYEEERFDESKLAQQTANILGCKNSRYIITPEEYFASVPYVMYHMEQPT
                     GDASAIVFAIGCKAAAENTNICYSGEGADEFFGGYNIYHKAECYGENLKTFYIGNTNIM
                     NEGEKRKILKKYNPDVLPIEVVKGIYEETEELDTLTNMSNVDIQIWLEGDIYFNIDKMS
                     TAVGLEVRMPLTDTRIFDIASRIPSEYKVKGKENKIAFRTAASKTLPEEIAFRNKLGFI
                     VPIRIWMADDQYNKDIRDKFNSEIADKFFNIDEINEIFNDYISGNSDNWRKIWMIYTFL
                     VWYEIYFVKC"
     gene            complement(8489..9085)
                     /locus_tag="CDR20291_0363"
     CDS             complement(8489..9085)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0363"
                     /db_xref="EnsemblGenomes-Tr:CBE02093"
                     /db_xref="GOA:C9YIG9"
                     /db_xref="InterPro:IPR007197"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="InterPro:IPR023821"
                     /db_xref="InterPro:IPR023822"
                     /db_xref="UniProtKB/TrEMBL:C9YIG9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="CDR20291_0363"
                     /product="Radical SAM-superfamily protein"
                     /protein_id="CBE02093.1"
                     /sec_met_domain="Radical_SAM (E-value: 3.9e-16, bitscore:
                     57.6, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNILYTIENSIYVNITNTCPCSCVFCIRNEKDEVANSGSLWLEHE
                     PSVDEVKEAFNKYNLDDYDEIVFCGYGEPLMRINELIEVAKFIKEKSSIKIRINTNGLS
                     DLIHNKKTAILLKDVIDTVSISLNAPNKEAYNRVTQPKFGEKSFDYMLGFARDCKKYIK
                     EVAFSVVDEISPEEIEESKQLAKKLDIPLRVRHKN"
     gene            complement(9112..9630)
                     /locus_tag="CDR20291_0364"
     CDS             complement(9112..9630)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0364"
                     /db_xref="EnsemblGenomes-Tr:CBE02095"
                     /db_xref="GOA:C9YIH0"
                     /db_xref="InterPro:IPR009825"
                     /db_xref="InterPro:IPR023812"
                     /db_xref="UniProtKB/TrEMBL:C9YIH0"
                     /locus_tag="CDR20291_0364"
                     /product="putative membrane protein"
                     /protein_id="CBE02095.1"
                     /transl_table=11
                     /translation="MNKVTSKKTTYIVTSALFASIICLTIAYILHIPVGGNNGYVHIGD
                     AFIYLAATILPTNYAIAASAIGAGLADLSTGAAIWVIPTIIIKPILVLFFTSKSDKIIN
                     KRNIVASVVAGIVGLVLYMFAEGIIIGSFTSAFVMSLLGLLQPIGSFIVFIILGMALDK
                     LDFKKRYFN"
     gene            complement(10001..10999)
                     /gene="ldhA"
                     /locus_tag="CDR20291_0365"
     CDS             complement(10001..10999)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0365"
                     /db_xref="EnsemblGenomes-Tr:CBE02096"
                     /db_xref="GOA:C9YIH1"
                     /db_xref="InterPro:IPR006139"
                     /db_xref="InterPro:IPR006140"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR029752"
                     /db_xref="InterPro:IPR029753"
                     /db_xref="UniProtKB/TrEMBL:C9YIH1"
                     /gene="ldhA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Leucine_reduction: Hacid_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hacid_dh"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_0365"
                     /product="(R)-2-hydroxyisocaproate dehydrogenase"
                     /protein_id="CBE02096.1"
                     /sec_met_domain="Hacid_dh (E-value: 4.1e-26, bitscore:
                     88.9, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="Hacid_dh_C (E-value: 1.3e-52, bitscore:
                     175.4, seeds: 144, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILVFGARDYEEPVIKKWSEEHKDVQVDIYPENMTEENVVKAKG
                     YDGISIQQTNYIDNPYIYETLKDAGVKVIASRTAGVDMIHFDLVNENGLIVTNVPSYSP
                     NAIAELAVTQAMNLLRKTPLVKKKVCEGDYRWIAELLGTEVRSITVGVIGTGKIGATSA
                     KLFKGLGANVIAFDQYPNSDLNDILTYKDSLEDLLKEADLITLHTPLLEGTKHMINKDT
                     LAIMKDGAYIVNTGRGGLINTGDLIEALESGKIRAAALDTFETEGLFLNKKMNPGELTD
                     PEINKLLSMEQVIFTHHLGFFTSTAIENIVYSSLSSAVEVIKTGTATNRVN"
     gene            11676..12875
                     /gene="hadA"
                     /locus_tag="CDR20291_0366"
     CDS             11676..12875
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0366"
                     /db_xref="EnsemblGenomes-Tr:CBE02098"
                     /db_xref="GOA:C9YIH2"
                     /db_xref="InterPro:IPR003673"
                     /db_xref="InterPro:IPR023606"
                     /db_xref="UniProtKB/TrEMBL:C9YIH2"
                     /gene="hadA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Leucine_reduction: CoA_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_0366"
                     /product="isocaprenoyl-CoA:2-hydroxyisocaproate
                     CoA-transferase"
                     /protein_id="CBE02098.1"
                     /sec_met_domain="CoA_transf_3 (E-value: 4.4e-92, bitscore:
                     306.7, seeds: 55, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLEGVKVVELSSFIAAPCCAKMLGDWGAEVIKIEPIEGDGIRVM
                     GGTFKSPASDDENPMFELENGNKKGVSINVKSKEGVEILHKLLSEADIFVTNVRVQALE
                     KMGIAYDQIKDKYPGLIFSQILGYGEKGPLKDKPGFDYTAYFARGGVSQSVMEKGTSPA
                     NTAAGFGDHYAGLALAAGSLAALHKKAQTGKGERVTVSLFHTAIYGMGTMITTAQYGNE
                     MPLSRENPNSPLMTTYKCKDGRWIQLALIQYNKWLGKFCKVINREYILEDDRYNNIDSM
                     VNHVEDLVKIVGEAMLEKTLDEWSALLEEADLPFEKIQSCEDLLDDEQAWANDFLFKKT
                     YDSGNTGVLVNTPVMFRNEGIKEYTPAPKVGQHTVEVLKSLGYDEEKINNFKDSKVVRY
                     "
     gene            12905..13714
                     /gene="hadI"
                     /locus_tag="CDR20291_0367"
     CDS             12905..13714
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0367"
                     /db_xref="EnsemblGenomes-Tr:CBE02100"
                     /db_xref="InterPro:IPR002731"
                     /db_xref="InterPro:IPR008275"
                     /db_xref="UniProtKB/TrEMBL:C9YIH3"
                     /gene="hadI"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Leucine_reduction: FGGY_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Leucine_reduction: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_0367"
                     /product="activator of 2-hydroxyisocaproyl-CoA dehydratase"
                     /protein_id="CBE02100.1"
                     /sec_met_domain="FGGY_C (E-value: 3.9e-05, bitscore: 21.2,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 1e-65, bitscore:
                     219.6, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKMYTMGLDIGSTASKGVILKNGEDIVASETISSGTGTTGPSRV
                     LEKLYGKTGLAREDIKKVVVTGYGRMNYSDADKQISELSCHARGVNFIIPETRTIIDIG
                     GQDAKVLKLDNNGRLLNFLMNDKCAAGTGRFLDVMAKIIEVDVSELGSISMNSQNEVSI
                     SSTCTVFAESEVISHLSENAKIEDIVAGIHTSVAKRVSSLVKRIGVQRNVVMVGGVARN
                     SGIVRAMAREINTEIIVPDIPQLTGALGAALYAFDEAKESQKEVKNI"
     gene            13723..14955
                     /gene="hadB"
                     /locus_tag="CDR20291_0368"
     CDS             13723..14955
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0368"
                     /db_xref="EnsemblGenomes-Tr:CBE02102"
                     /db_xref="InterPro:IPR010327"
                     /db_xref="UniProtKB/TrEMBL:C9YIH4"
                     /gene="hadB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Leucine_reduction: HleuD2"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_0368"
                     /product="subunit of oxygen-sensitive
                     2-hydroxyisocaproyl-CoA dehydratase"
                     /protein_id="CBE02102.1"
                     /sec_met_domain="HleuD2 (E-value: 1.3e-268, bitscore:
                     887.1, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKMSEKKEARVVINDLLAEQYANAFKAKEEGRPVGWSTSVFPQEL
                     AEVFDLNVLYPENQAAGVAAKKGSLELCEIAESKGYSIDLCAYARTNFGLLENGGCEAL
                     DMPAPDFLLCCNNICNQVIKWYENISRELDIPLIMIDTTFNNEDEVTQSRIDYIKAQFE
                     EAIKQLEIISGKKFDPKKFEEVMKISAENGRLWKYSMSLPADSSPSPMNGFDLFTYMAV
                     IVCARGKKETTEAFKLLIEELEDNMKTGKSSFRGEEKYRIMMEGIPCWPYIGYKMKTLA
                     KFGVNMTGSVYPHAWALQYEVNDLDGMAVAYSTMFNNVNLDRMTKYRVDSLVEGKCDGA
                     FYHMNRSCKLMSLIQYEMQRRAAEETGLPYAGFDGDQADPRAFTNAQFETRIQGLVEVM
                     EERKKLNRGEI"
     gene            14955..16082
                     /gene="hadC"
                     /locus_tag="CDR20291_0369"
     CDS             14955..16082
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0369"
                     /db_xref="EnsemblGenomes-Tr:CBE02104"
                     /db_xref="InterPro:IPR010327"
                     /db_xref="UniProtKB/TrEMBL:C9YIH5"
                     /gene="hadC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Leucine_reduction: HleuD1"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_0369"
                     /product="subunit of oxygen-sensitive
                     2-hydroxyisocaproyl-CoA dehydratase"
                     /protein_id="CBE02104.1"
                     /sec_met_domain="HleuD1 (E-value: 2.7e-248, bitscore:
                     820.1, seeds: 30, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAILSKMKEVVENPNAAVKKYKNETGKKAIGCFPVYCPEEIIHA
                     AGMLPVGIWGGQTELDLAKQYFPAFACSIMQSCLEYGLKGAYDELSGVIIPGMCDTLIC
                     LGQNWKSAVPHIKYISLVHPQNRKLEAGVKYLISEYKGVKRELEEICGYEIEEAKIHES
                     IEVYNEHRKTMRDFVEVAYKHSNTIKPSIRSLVIKSGFFMRKEEHTELVKDLIAKLNAM
                     PEEVCSGKKVLLTGILADSKDILDILEDNNISVVADDLAQETRQFRTDVPAGDDALERL
                     ARQWSNIEGCSLAYDPKKKRGSLIVDEVKKKDIDGVIFCMMKFCDPEEYDYPLVRKDIE
                     DSGIPTLYVEIDQQTQNNEQARTRIQTFAEMMSLA"
     gene            16130..17263
                     /gene="acdB"
                     /locus_tag="CDR20291_0370"
     CDS             16130..17263
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0370"
                     /db_xref="EnsemblGenomes-Tr:CBE02105"
                     /db_xref="GOA:C9YIH6"
                     /db_xref="InterPro:IPR006089"
                     /db_xref="InterPro:IPR006091"
                     /db_xref="InterPro:IPR009075"
                     /db_xref="InterPro:IPR009100"
                     /db_xref="InterPro:IPR013786"
                     /db_xref="UniProtKB/TrEMBL:C9YIH6"
                     /gene="acdB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Leucine_reduction: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_0370"
                     /product="acyl-CoA dehydrogenase, short-chain specific"
                     /protein_id="CBE02105.1"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 4.4e-51, bitscore:
                     170.7, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.5e-26, bitscore:
                     90.1, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 6e-34, bitscore:
                     114.8, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYNKEQELLRKAVRDFVSKELDTLPAEMDKTGVMPKELIKKLAD
                     AKFISSNIPEEYGGGGAGYVSYAIVMEEIARRCASTATFVTAGSSLASLPILYNGTEEQ
                     KQKYLKGIATGELIGAFGLTEPGAGSDAGGQQTTAELVGDHYILNGRKTFITNGPFCDV
                     AIVIAVTDRSKGLRGTSAFIVESKWDGFSTGAHEDKMGIRGTETSDLIFENVKVPKENL
                     LGKEGQGFKIAMGTLEVGRIGVAALALGIAQGALDEAVKYTKQRVQFGKPIAKFQNTQF
                     TIADMETKVCAARGLVYDAAQKRDAGMRVAQESAMAKYYASEIANEVAYKALQLHGGYG
                     FIKDYEIERMYRDARIVSIYEGTSEVQKMVISSNVLK"
     gene            17296..18081
                     /gene="etfB1"
                     /locus_tag="CDR20291_0371"
     CDS             17296..18081
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0371"
                     /db_xref="EnsemblGenomes-Tr:CBE02107"
                     /db_xref="GOA:C9YIH7"
                     /db_xref="InterPro:IPR000049"
                     /db_xref="InterPro:IPR012255"
                     /db_xref="InterPro:IPR014729"
                     /db_xref="InterPro:IPR014730"
                     /db_xref="UniProtKB/TrEMBL:C9YIH7"
                     /gene="etfB1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Leucine_reduction: ETF"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_0371"
                     /product="electron transfer flavoprotein beta-subunit"
                     /protein_id="CBE02107.1"
                     /sec_met_domain="ETF (E-value: 4.2e-51, bitscore: 171.1,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILVCVKQVPDTNEVRINKETGTLIRDGVPSILNPDDANALEEA
                     LKIKDEHDDVTITVITMGPPQADFMLRECLAMGADDAILLSDRAFGGADTWATSNTIAA
                     GISKVGDYDIIFAGRQAIDGDTAQVGPQIAEKLDIPQVTYVQDFKIEGKDIIVQRQLED
                     GYELIKVSTPVLLTAVKELNTPRYMSVDKIVKAYKHDVKVWTIDDLDVNKEEVGLKASP
                     TKVFRSFTPEPRGKGEILEGKADEIASKIIIGLKQKHII"
     gene            18100..19137
                     /gene="etfA1"
                     /locus_tag="CDR20291_0372"
     CDS             18100..19137
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0372"
                     /db_xref="EnsemblGenomes-Tr:CBE02109"
                     /db_xref="GOA:C9YIH8"
                     /db_xref="InterPro:IPR001308"
                     /db_xref="InterPro:IPR014729"
                     /db_xref="InterPro:IPR014730"
                     /db_xref="InterPro:IPR014731"
                     /db_xref="InterPro:IPR018206"
                     /db_xref="InterPro:IPR029035"
                     /db_xref="UniProtKB/TrEMBL:C9YIH8"
                     /gene="etfA1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Leucine_reduction: ETF_alpha"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Leucine_reduction: ETF"
                     /gene_kind="biosynthetic"
                     /locus_tag="CDR20291_0372"
                     /product="electron transfer flavoprotein alpha-subunit"
                     /protein_id="CBE02109.1"
                     /sec_met_domain="ETF (E-value: 2.2e-51, bitscore: 172.0,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 7.5e-37, bitscore:
                     123.0, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDIKDLSSYKNVWIFAEQREGKIAPVVIELLGEGRKLAKEVDAE
                     LCAILLGKDVDGLAKELITFGADKVYVADDALLEKYTTDAYTKVIKDAIDEIKPEIMLF
                     GATHIGRDLAPRIASRVGTGLTADCTKLEIDPEDKKIKQTRPAFGGNIMATIICPNHRP
                     QMSTVRPGVMDKAEKDETRTGEVIALDYKITQDDIRTTVLETVKTKKDLVSLTDANVIV
                     SGGLGLGGPEGFEMLKKLADKLGGVVGSSRAAVDAGWIDHSHQVGQTGTTVKPNLYIAC
                     GISGAIQHLAGMQSSDFIIAINKNPAAPILEIADYGVVGDLHEIVPMLIEKLDSVDDLL
                     EAIKA"
     gene            19620..21251
                     /locus_tag="CDR20291_0373"
     CDS             19620..21251
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0373"
                     /db_xref="EnsemblGenomes-Tr:CBE02111"
                     /db_xref="GOA:C9YIH9"
                     /db_xref="InterPro:IPR000014"
                     /db_xref="InterPro:IPR002078"
                     /db_xref="InterPro:IPR002197"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR025662"
                     /db_xref="InterPro:IPR025943"
                     /db_xref="InterPro:IPR025944"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:C9YIH9"
                     /locus_tag="CDR20291_0373"
                     /product="sigma-54-dependent transcriptional regulator"
                     /protein_id="CBE02111.1"
                     /transl_table=11
                     /translation="MDNNLIGLIEHVENPAILCKESGEIIYCNHLIDSIFSFLDIKKPR
                     NINELDSNFDKTEILTDSKKKIAFRELRMTAHIYNMKDNNNENNIVYLFEKSLISDKVI
                     EDIIEHIDEVVVVFNKDGVIEKMNTVSDEILPFKRTEVLGRNITDLVRQGLVEEPIILN
                     MLKVKKKIYRNIVYPDGKLIAYTAVPRWDSKGKLTGGVLTGRDISRVIKLESQIKYSDI
                     SEDTEYISQSKIMDNIKKVVKRAAASDSSIFINGESGVGKEIIARTIYKYSSRRDKPFI
                     AINCGAIPNELLESEFFGYEEGSFTGAKKKGKKGLFEEANGGTIFLDEIGELPMQMQKK
                     LLRVIQENTITRIGGSKPIKIDVRYISATNISHEDLRNNLKFRQDLYYRLSVIPVKIPP
                     LRERKEDIVPLVNYFLKLYNEKYNREVEVSPKVIELLEEYSWPGNIRELKNIIERFVVL
                     SAKNVIGEDEFNMLINLDMIDNETDDLSPIVVNGIMNLNDAYKIVDQIMISKAINKYGS
                     ITKAAEVIGIYPSTIHRKIKSGHIHV"
     gene            complement(21386..22312)
                     /gene="fba"
                     /locus_tag="CDR20291_0374"
     CDS             complement(21386..22312)
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0374"
                     /db_xref="EnsemblGenomes-Tr:CBE02113"
                     /db_xref="GOA:C9YII0"
                     /db_xref="InterPro:IPR000771"
                     /db_xref="InterPro:IPR011289"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="UniProtKB/TrEMBL:C9YII0"
                     /gene="fba"
                     /locus_tag="CDR20291_0374"
                     /product="putative fructose-bisphosphate aldolase"
                     /protein_id="CBE02113.1"
                     /transl_table=11
                     /translation="MALITTKEMFKKAYEGGFAIGAFNISDLEQLQGVLKAAKAKNSYV
                     MIQASMSAVKYAGPHTLVEMVKAASDEIGVDVALHLDHGPNMDAIKTCIDAGFSSVMID
                     GSHFDFEENVRITKEAVEYAHSKGVVVEAELGVLAGTEDDVTSDVHKYTQPAEAVEFVE
                     RTGVDSLAIAIGTSHGAFKFKGEAKLRFDILEEIQSKLPGFPIVLHGASAVDQNAVATC
                     NEFGGNIAGAKGVPVDMLRKASSMAVCKINMDTDLRLAMTAAIRKFLAENPKEFDPRKY
                     IGAGRDAIQAVVESKIDDVLGSANSIN"
     gene            22642..22971
                     /locus_tag="CDR20291_0375"
     CDS             22642..22971
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0375"
                     /db_xref="EnsemblGenomes-Tr:CBE02114"
                     /db_xref="InterPro:IPR014347"
                     /db_xref="InterPro:IPR015017"
                     /db_xref="UniProtKB/TrEMBL:C9YII1"
                     /locus_tag="CDR20291_0375"
                     /product="conserved hypothetical protein"
                     /protein_id="CBE02114.1"
                     /transl_table=11
                     /translation="MPQIKIRGINENDICKISKKMINDLVEAVKCPRDYFEIECIKSVA
                     IRDGKIADVYPFVEVAWFDRGQEVQDIVARIITDSIRNNLDVESMDLAFTVFEKEKYYE
                     NGEHF"
     gene            order(22971..23174,25005..25577)
                     /locus_tag="CDR20291_0376"
     CDS             join(22971..23174,25005..25577)
                     /EC_number="5.4.99.-"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0376"
                     /db_xref="EnsemblGenomes-Tr:CBE02116"
                     /db_xref="GOA:C9YII2"
                     /db_xref="InterPro:IPR000748"
                     /db_xref="InterPro:IPR002942"
                     /db_xref="InterPro:IPR006145"
                     /db_xref="InterPro:IPR018496"
                     /db_xref="InterPro:IPR020103"
                     /db_xref="UniProtKB/TrEMBL:C9YII2"
                     /locus_tag="CDR20291_0376"
                     /product="pseudouridine synthase"
                     /protein_id="CBE02116.1"
                     /transl_table=11
                     /translation="MAKKQRIDKILSNLGYGSRSEIKKYCKQGSVVVNGSEVSNPGTQV
                     DTENDEILFNGEEVIYREYIYLIMQNSVKQEPCDFSHGRFRMNKPDGYISATTDKYDPT
                     VLDLIDLSYLAFEPFPVGRLDKDTEGLLVLTNDGKLSHRVLSPKKHVPKTYYAKIDGVV
                     TEEDVEAFLEGVVLDDGYKTMPSQLNILKSDDESEIELTIHEGKFHQVKRMFESVGKKV
                     VYLKRLSMGNLKLDESLELGEYRELTDEEVKLIEER"
     gene            23822..24940
                     /locus_tag="CDR20291_0377"
     CDS             23822..24940
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0377"
                     /db_xref="EnsemblGenomes-Tr:CBE02118"
                     /db_xref="InterPro:IPR001959"
                     /db_xref="InterPro:IPR010095"
                     /db_xref="InterPro:IPR021027"
                     /db_xref="UniProtKB/TrEMBL:C9YII3"
                     /locus_tag="CDR20291_0377"
                     /product="transposase-like protein b"
                     /protein_id="CBE02118.1"
                     /transl_table=11
                     /translation="MIAVEKAYKFRMYPNKKQQELINKTFGCCRFVYNKYLAKRIEVYK
                     NDKETFTYKQCSSDLTNLKKELKWLKEPDKFSLQNALKDLDNAYKKFFKEKAGFPKFKS
                     KKINRFSYKTNFTNGNIMYCGQHIKLPKLGMVKIRDKQVPKGRILNATISKEPSGRYYV
                     SLCCTDVDIEVFENTNNQIGLDLGIKEFCISSCGEFIENPKYLKKSLNKLAKLQRELSR
                     KTIGSLNRNKARLKVARLQEHIANQRNDFLQKLSTKLIKENDIICIEDLQVKNMIRNCK
                     LSRLISDVSWSEFIRQLEYKANWHGRQIVKVGKFFASSQICNKCGYKNEEVKDLSIREW
                     ICPSCNETHDRDINASINILKEGLRLITTQNK"
     gene            25604..26965
                     /locus_tag="CDR20291_0378"
     CDS             25604..26965
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0378"
                     /db_xref="EnsemblGenomes-Tr:CBE02120"
                     /db_xref="GOA:C9YII4"
                     /db_xref="InterPro:IPR001566"
                     /db_xref="InterPro:IPR010280"
                     /db_xref="InterPro:IPR012340"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="UniProtKB/TrEMBL:C9YII4"
                     /locus_tag="CDR20291_0378"
                     /product="putative tRNA (Uracil-5-)-methyltransferase"
                     /protein_id="CBE02120.1"
                     /transl_table=11
                     /translation="MSVKKKDVIEFEVDKMEFGGTSLSQVGDRVIHMKGGISGQKVRAG
                     VKKVRSKKAEVKMIELLENSPLETEETCKHFRECGGCTLLSVPYEKQLEIKEKQVMDLF
                     LKQDLFGFQFLGIEGSPENKYYRNKMEYTFGDEVKNGPLTLGLHKKGKHIDIQTVEECM
                     LVDEDFSKILVSSVEFFNEKKLPYYRTMNHKGYLRHLVVRKGIHTNEIMVNIVTSSQED
                     FDMNEFKDMLLGIDLKAELVGVLHTINDGLADAVQCDELRVLYGRDYIQEEILGLKFKI
                     SPFSFFQTNTKGAEVLYSIARDFIGDYNDKVVFDLYSGTGSIGQVMAGAAKKVYGIEIV
                     EEAVVAANENAKLNGLTNCEFIAGDVAKVVKDLKDKPDLIIVDPPRPGIHKDAIRDICG
                     FGAKEIVYISCNPKSLVVDLVDFKGYGYEIKMVKCMDMFPNTPHCETVVKLIRE"
     gene            27488..28522
                     /locus_tag="CDR20291_0379"
     CDS             27488..28522
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0379"
                     /db_xref="EnsemblGenomes-Tr:CBE02121"
                     /db_xref="UniProtKB/TrEMBL:C9YII5"
                     /locus_tag="CDR20291_0379"
                     /product="putative exported protein"
                     /protein_id="CBE02121.1"
                     /transl_table=11
                     /translation="MFKKKLIAVAMSITMISVGSFSYAHSGRTDSSGGHRDNKNKSGLG
                     SYHYHCGGYPAHLHNNGGCPYTGGGSSSGTTTSVNNEEKQKRSVGEKGYNQGYEDGYKG
                     NYSSSNYSGDYSDTYESKYSEGYEKGKAKLEEEEKVAKETGYNLGLTGAKSNNTYEKEV
                     LKNAYDTGYSTGYNEYKTKKIEEYKAKGIEDSNKDKEKMTFEENIDSEFIDAYNNAYDE
                     IQEQLKNDYTTQGFESAIKGERFDTSTIGNVKYANWFKEGYDNGKVKLPKAKESVYNQG
                     YNEEDFSIPYEMKSIETKLKGVYDEGLEKREEEKSRNATYGVGAGTAAVVAGVVYKNKK
                     RKKI"
     gene            28609..28812
                     /locus_tag="CDR20291_0380"
     CDS             28609..28812
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CDR20291_0380"
                     /db_xref="EnsemblGenomes-Tr:CBE02123"
                     /db_xref="InterPro:IPR025330"
                     /db_xref="UniProtKB/TrEMBL:C9YII6"
                     /locus_tag="CDR20291_0380"
                     /product="conserved hypothetical protein"
                     /protein_id="CBE02123.1"
                     /transl_table=11
                     /translation="MGFNFRKSINLGGGLKLNLGKKSVGISAGVKGARVSVNSKGRKSA
                     TLSIPGTGISYTKTSTKKRKPK"
ORIGIN
        1 agcagttttt ttcttttgta gtgatttaaa gaaagaccca gtagccagta atgtgataaa
       61 gtgttgtgaa gaaataatgg atttaaatca aactgatatt gttattgatg ataattttgt
      121 attagaattt aaggataaaa acaataactt atttcatttt gtaaaaacaa aagatgtaat
      181 aagtcataat tataaatatt atcttccaat tttaaataga catttcagag attatgattt
      241 tgcaggagtt gtaaattggc atgagggaga aaatgctcca gaacatatcc taacagctca
      301 tacaattgga gatgttccaa caggagaatt tggaaattca aatccaagat actttaaaaa
      361 tctaatcaat gctattgagg atataaaaaa tgaaaatcta cttgatgaat ttactacatt
      421 aacagaagca actcactggt ctggaacaac atatggtgaa gaatctaaat taattacaga
      481 atattctgta cctatgttgg atattgagat aggaagtagt agtgatagtt ttaataatag
      541 tatagcaata caggtattgg caaaatcatt aattagagta tttgattgtg atgaaccttt
      601 gaagacttta ttatgtgttg gaggggtaca ttttgagaaa tctttctcag atattataaa
      661 aaataaagaa tataacatat caattggaca tgtattgcca aatcaatgga ttgtaagtgg
      721 aatgtatgat gatgaatcgg gatttgagaa actagaaaag tgtataaata gtattgaagg
      781 tggaattgat tgtatagttt ttcatgataa attaaaaggt acctataaag agcaatgccg
      841 taaactaggt gaaaaactta atgtacctgt atttaaacat aaaatattaa aaaatcccaa
      901 agacttacct atatggtagt cttatacagt taatataaca ataagtcgga ttaattttta
      961 agcgaggtca aaaatgatat tatcttattt tgcattatta attagagtag tgctattagc
     1021 ttttgaaaga gtagttgtaa gattattagg tgatgaagaa ggagatattt ataaaaatat
     1081 agcttcatca tttctatttt tctttatagg gggagtatgt ttacttccat ttagcataat
     1141 ggatagagtt agtgattggt cgtttttaat accatgttat ataagtagtt tagtctattc
     1201 aattggttca gtagcgtatg taacgtcttt agcaactggg gaagtttcac ttgttactcc
     1261 aataaatagt ttaaattcat tgtttttact gcttttatca gttatatttt taggtgaagg
     1321 tttaagttta gcaaaagttg caggaatcat aattatgatt ggtggagtgt ttatattaaa
     1381 aaaagtaagc tcttttttaa agaatgtctc tgtaattttt aacaatttac catgtagatt
     1441 aatgttttta tacatatttt tgcagtcagt aggaagagta ttggataagg ctttttttgt
     1501 acaagtatct cctatattat attcaactat actgtatttt ttcgtaggtt taaatttatt
     1561 tatcttttta gcatttaaaa agaaacaaaa aataatttgt gagattttta gtaataaaaa
     1621 ggggctttca attttaagtg gtgctattaa tggatattct tatttagcat tattaattgc
     1681 tttaaataat ctagaactta gtatagcaga gccattttct caagtatcta tgataataac
     1741 tttaatactt gctcatttta tattcaaaga aaatataaaa gaaaaaatac caggttcaat
     1801 tttgatacta attggtgggt ggctactgtt actttaattg acataaaaaa tgaattataa
     1861 aggtgctatt agttagtatc agaaaattta aaaaagtatt gacaattctt ttaggcaaat
     1921 gttaatataa taatacaaaa tagtataaat agaagacatg ttactggtaa tgcaggcagg
     1981 atcgaatata ttgctttgat ttttcaaggt gtttatatag gttctgcctt ttttgcatct
     2041 tgaatggcca ttcataaaaa attatggaga aggagattac aagatgaatt ataaaaaaac
     2101 tgccattgac attattgaac aagttggtgg ttcaaaaaat attttagctt tagaacactg
     2161 ttcaactaga ctacgcttta agttgattga tagaagtaaa gtcaatcagg atgctttaaa
     2221 aaaagtacaa ggtgttatga gtatagttaa tggggcacaa tttcaagttg tcattggaaa
     2281 tagtgttgtt gatgtgtatg atgaaatttt aaaagtttgc cctttagata caaatgatag
     2341 tactgtaaaa actgaagaaa aaataaactt aggaacaaga tttatagaat ttattattaa
     2401 tatttttcaa ccactgattt ttgctattgc aggagctggt attttaaaat cactgttgat
     2461 gttattagca atgtttaata ttttaaaatc agattctact atatatacat tattagttgc
     2521 tatttcagat gcaacattct atttcctacc tcttatggta gctgtaacta ctgccaatgt
     2581 attgaaatgt aatcgtttag tagctattgc cgctgtagga tacttattgc ttccagcaac
     2641 aacaactgct ttaagtgaag gtgtcgaact atttggattt acaattccaa acattgccta
     2701 taatgcacaa gttttcccgg ctatcttatg tgtgtctttt ttggcaacaa tggagaaaat
     2761 ttttaacaag tattcaccaa aaccaattcg aactttcttt gttcctatga tgtctttggc
     2821 aattactgtt ccaattactc taactatttt aggtccttta ggatataacg ttggtacaat
     2881 ttttacaacc attattttat tcttatataa caaaatggga ttcttagttg taggattact
     2941 tgctgctttt cttccattta tggttgcaac aggaatgcac aaagcactaa taccttattc
     3001 aattaataca attggaaagt tgggttatga agctttatat atgacatctt cattagccca
     3061 caatatttct gaaagtggtg cttgttttgc agtagccttg cgaacaaaag atgaaacatt
     3121 aaaacaaaca gcattatctg caggaatttc tgccttgatg ggaattacag agccagcttt
     3181 atatggtatt actttacaac ataaaagagc aatgttaggt gttgtattct caagtgcaat
     3241 ttctggtaca tttttaggat tatttgcagt aaaaggattt gtaattgttg gaccagggct
     3301 tgccagtatg agtatgttta ttgacccaaa caatggaaac aatttgattt ttgcgagtat
     3361 tggttttgtt attgcaatat taggctcgtt tattattaca ctgattattt ggaaggaaga
     3421 tacaaataca gtagagtcat caattggaga tgttgttgaa gaagagctag aagaagaaaa
     3481 agaagtaaat atcttagtaa ctccagtaga aggaaaagta atagatttaa gtaaggttaa
     3541 tgatgaacta tttgcaagta agactttggg agatggagtt gcaattatac cgaccaatgg
     3601 aaatttatac gcaccttgtg attcagaagt tgtgatgtta tttgaaacaa aacatgcaat
     3661 tggtttaaga acaaaaaatg gggctgagat tttgattcat attggaataa atactgtaag
     3721 tatgaatgga gatggattta aaacatttgt taagacaggc gataatgtaa aagaaggaga
     3781 tttattaatt caatttgatt tagacaaaat ctcacatgct aatttagatt caactgttat
     3841 gattgtaaac aataatggag cagattatgc ttataaagtg ttaaaccagt cttatggcaa
     3901 tgtaaaaaaa ggaagtatct tgtttgatgt aaagggagga atataaatat gagaaagttt
     3961 ccagaaggat ttctttgggg aggagctaca gctgctaatc aatttgaagg tggttggaat
     4021 ttaggtggta aagggtggtc tgtatcagat gtagcaaagg cacactttga tgcagatgtg
     4081 aaagactata aatctaataa tgaaatcaca acaaaagata tagaagaagg attagcacat
     4141 cctgaagatg aagtaaatta tccaaaacgt catggtagtg atttttatca tcactataaa
     4201 gaagatattg ctctaatggc agaaatggga tttaagacat atcgaatgag tattgcttgg
     4261 tctcgtattt ttccaaatgg agatgataaa gagccaaatg aagaaggttt acagttttat
     4321 gatgatgtat ttgatgagtt gataagttat ggaattgaac cacttgttac tatgtcacat
     4381 tatgaaccac cattaaatat cgttttaaac tatgatggat ggtattcacg acaagttatc
     4441 aatatgtttg ttaggtatgt agaaactatc tgtgaaagat ataaaaacaa agtgaaatat
     4501 tggcttacat ttaatgaagt tgattctatg attcgtcatc cgtacactac tggtggttta
     4561 gttcgagacc gttttaagga taaaaacttt gaggaagtta tttttcaagc tatgcatcat
     4621 caatttgtag ctagtgccct tgcaacaaaa atttgccatg agattattcc aaattcaaaa
     4681 gtagggtgta tgttaacaaa attaacgtat tatccatata catgtagacc agaagatgtt
     4741 ttggcaactc aacaaaaaat gagaagtatt tatgcatata gtgatacgca ggtttttggt
     4801 gagtatccag tatatttact ttcgtatttt aaaaataata acattcaaat agcaaaagaa
     4861 gaacatgatg atgaaattat gaaaaagtat ccagtagatt ttatttcatt ctcttactat
     4921 atgtcttctt gtgaggcagc tgatacaact ggattagata ttacacctgg gaatacgtta
     4981 ttagctgtaa aaaatcctta tttagaaatg agtgaatggg gttggcaaat tgattcaata
     5041 ggtctacgta tatctttgat tgaattatat gatagataca gaaagccttt atttatagtt
     5101 gaaaatggat tgggagctaa agatatttta actgaagata aaaaagttca tgaccaatat
     5161 agaattaatt atttaaaaga acactttaaa tgtatgttag atgcgattat cgaagatggc
     5221 gttgaacttt ggggatacac ttcatggggt tgtattgatt tggtcagtga atcaacgaaa
     5281 caaatgtcaa aacgttatgg atatatttat gtggatgctg atgattatgg aaaggggaca
     5341 tataatcgat ataagaaaga tagtttttat tggtataaaa aagtaattga aaataatagt
     5401 atagatttta aatgaccaat agaaggtgag caaataaaat gaactacata ataaagaaag
     5461 ttttgaactc gagcgttgtt ttagttcatg atgcaaagta taatgaattt attttgctag
     5521 ggaaaggaat tggatatggt aaaaaaacag gagaatatat ttgtggttcc aatgataatc
     5581 aaatgtttgt ccctgttgaa aatacaaaat caaaaaaatt tttagaatta atggatgata
     5641 ttcctgtcga cattttaaag ataacacagg aaataatagt agaggcagaa aagttattga
     5701 actcatcttt taataaaaac ttatacttaa tattagcaga ccattttaac tttgcaattg
     5761 aaaggatgcg taaaggaata aaaattacaa atcgagtatt ttgggaaata aaaaattatt
     5821 atccaaatga gtttaaggtt ggaatggttg caatttatat ggtagaggag agattgggca
     5881 ttcaattacc agaggaagaa gcagctaaca ttgctttcca ttttgcaaat gctatggctt
     5941 cagatggaaa ttcatatgat acgattaagt atgccaaagt aattggagaa ataattaata
     6001 tttttgtttt ttctttgaat agaaccttag ataaaaagag tatgcattat atgagattta
     6061 taacacatat aaaatttttt gtggaaagat ttttttcaga tagtatgtta agcagtggtg
     6121 atgatttatt atttaatcaa atgaaaaggt caaatccaaa agaaatgtta attgcattaa
     6181 aagttagaga ttttttagaa aagaaatatg gaaaaaagtt aacaaatgag gaaatagctt
     6241 tcttggttgt ccatatcgca cgagttaagc aatagagtga attactaata ttatcttata
     6301 cgtctacatg gtagaaaatt gaaagaaggt aaagtatata aagaaactga gacatattat
     6361 tttgttgttc attatgttta ttttatgagt gtatcctgtt aaaaatttaa gttaatattt
     6421 ataattaaaa tatacaaata gttaaaataa gtttatgtgg ttatgaattt attttaacta
     6481 tttttttgtt taatggaaaa tatgttttat aactagaatt ttatttttaa ttaattataa
     6541 tacaaaaaac tttataaaat cttcagaatt tcttaaagaa tatgtaagta acataagata
     6601 tattatattt agttggtaat ataaaggggg caatatttat gaagaataaa aaattcaatg
     6661 ttataacact gataatactt gataatcata tttatgccat taataaagag cagattagta
     6721 ctaattcaaa aagaatttac tttgaaaaaa gtcgattttt cagtgattat aagtgaataa
     6781 atatatataa acatttaata aatttagaag ttaaatgttt taatacgaaa ggatacacat
     6841 atgataaatt tagaagaaaa gtatttaaca cgaaaagaca catatatgat aaaaattcta
     6901 gaatacaatg gacatattcg aaactggaaa gttctctgtg aagaacttgg aatcgattct
     6961 tcattatgta gagatgagcg tgaacgagca attttagtgg aagcatataa gacatgggga
     7021 tatgatatgg caaatcacat gcatggaatg tttgcctttg cattatggga tactgtggaa
     7081 aagaaactct tctgcctaag agaccagttt ggagtaaaac ctttctatta ttatgagact
     7141 gaaaatggga agcttctcta tggttcatct attcgtaaga ttatggagca accaggattt
     7201 gtgaaagagt taaatgaaga catgttacag atttatatgt ctttcacata tgtagcaggt
     7261 gaaaatacat tcttccgtgg agtaaagaag cttatgccag gacattacct tgtctatcag
     7321 aataaaacag tatgtattgg tcgttattgg aaacctgaat ttcatcctga ccacagcaag
     7381 tctattgagg aatggacgga tgaaattcat acaacacttc agaaaattat gccagaggta
     7441 aaatcagaga atgaaactgc agagttattc ttatcaggag gtgttgattc atcttatata
     7501 ttggcaatgt cagatataga aaaaacaggt tcatgtggtt atgaggaaga gcgttttgat
     7561 gaatcaaaat tagcacaaca gacagctaat attcttgggt gtaaaaattc gagatatata
     7621 attacacctg aagagtattt tgcgtcagta ccttatgtaa tgtaccatat ggagcaacca
     7681 actggagatg catctgctat cgtttttgct attggatgca aggcagcagc tgaaaacaca
     7741 aatatctgtt actctggaga aggagcagat gagttttttg gtggatataa tatataccat
     7801 aaggcagagt gttatggaga gaatttgaag acattttata ttggaaatac aaacattatg
     7861 aatgagggtg agaaaagaaa aattcttaag aaatacaatc ctgatgtgct tcctattgaa
     7921 gtggtaaaag gaatttatga agaaacagaa gaactagata cacttactaa catgtcaaat
     7981 gtagatattc aaatatggtt ggaaggagat atttatttta atatagataa aatgagtact
     8041 gcagttggat tggaagtcag aatgcctctt acagatacaa gaatatttga tattgcatcc
     8101 agaataccat cagaatataa agtgaaagga aaagagaata aaattgcctt tcgtacagct
     8161 gcatcaaaaa cattaccaga agagattgct tttagaaata aattaggatt tattgtgcca
     8221 attcgtatat ggatggctga tgaccaatat aataaggata tccgagataa attcaatagt
     8281 gagatagcag ataaattctt taacatagat gagattaatg agatttttaa tgactacatt
     8341 agtggaaact ctgataattg gagaaagatt tggatgattt acacattcct agtgtggtat
     8401 gaaatctatt ttgtaaaatg ttaatacaag aggaagaatc acctgaaaga ccattcaggt
     8461 gattcttaat gttttataat tttacttgct aattcttatg tctaactctt aatggtatat
     8521 caagtttttt tgccagttgt ttagattctt ctatttcttc tggagatatt tcatctacta
     8581 ctgaaaaagc tacttctttt atatattttt tgcaatctct tgcaaaacct aacatatagt
     8641 caaatgattt ttctccaaac tttggttgag taactctatt ataagcttct ttatttgggg
     8701 cattaagact tattgatact gtatctataa catcttttaa cagaatagct gtttttttgt
     8761 tatgtattaa atcacttaga ccatttgtat ttattcttat ttttatgcta cttttttctt
     8821 ttataaactt tgctacctct atcaattcat ttattctcat taatggttcg ccatatccac
     8881 aaaatacgat ttcatcatag tcgtctaaat tgtatttatt gaaggcttct tttacttcat
     8941 ctacacttgg ctcatgctcc aaccataaac taccactatt tgcaacttca tctttttcgt
     9001 ttcttataca aaaaacacaa ctacatggac atgtattagt tatatttaca tagatactat
     9061 tttcaattgt atataagata ttcataattt tccctccata aatttaaatt cttaattaaa
     9121 ataacgtttt ttaaaatcaa gtttatcaag tgccatacct aagattataa aaacaataaa
     9181 acttcctatt ggctgtaata agccaagtaa gctcattaca aatgcacttg taaaacttcc
     9241 aataattata ccttcagcaa acatgtataa aactaatcct actatacctg ctacaaccga
     9301 agcaactata tttctcttat ttattatctt gtcactttta gaagtgaaaa ataatacaag
     9361 tattggtttt atgattatag ttggtattac ccagatagca gcacctgtag ataaatcagc
     9421 tagaccagca ccaattgcag aagcagctat agcatagttt gttggcaaaa tagttgcagc
     9481 tagataaata aaagcatctc ctatatgaac atatccattg tttccaccaa ctggaatatg
     9541 taatatatat gctattgtca ggcatattat ggatgcaaat aatgctgaag taacaatata
     9601 ggtagttttt ttagaagtaa ctttattcat tttttccaat atactccctc cctaaaaatc
     9661 cagagctaac ataattgtta tgttttctta taaatatatt aatattaatc atacaatttt
     9721 catagtttgt taggtgtttt ttttgtaaaa tacagattgt acccattcaa atgtatataa
     9781 ttagaaaagt aaaaataggt aaaatgtata gagtaggagt agttagagta agttaatata
     9841 aatttaattt ggtataaata agaggagtac aagtttaata taaaaaataa tataagagag
     9901 tctactcaat atatactgag ctgactctct tatatttggg aaattaaagg ctattttgtt
     9961 agataatagc taattaatga aaaaatatat ttataaaata ctaatttact ctattagtag
    10021 cagttcctgt ttttataact tctacagcac tacttaaact agaataaact atattttcaa
    10081 tcgctgtact agtgaagaaa ccaaggtgat gagtgaatat aacttgttcc atagaaagaa
    10141 gtttatttat ttctgggtca gttaattctc caggattcat ttttttgttt aagaacaatc
    10201 cttcagtttc aaatgtatca agggcagcag ctctaatttt tcctgactct agtgcttcta
    10261 ttaaatcccc tgtattaatt aaaccaccac ggccagtatt tactatgtaa gctccatcct
    10321 tcattatagc tagagtatct ttatttatca tatgttttgt tccttcaagt aaaggagtat
    10381 gtaatgttat aaggtcagct tcttttagaa ggtcttctaa agaatctttg taagttaata
    10441 tatcatttaa atcactattt ggatattggt caaatgcaat tacattagct cctaggcctt
    10501 tgaataattt tgcagaagta gcacctattt ttcctgtacc tataacacca actgtaatag
    10561 atctaacttc tgttccaaga agttcagcta tccaacggta atcaccttca cagacttttt
    10621 tctttactag aggagtcttt cttaaaaggt tcatagcttg agtaacagct aattcagcta
    10681 ttgcattagg tgaataagaa ggaacgtttg taacgataag tccattttca ttaactaaat
    10741 caaaatgtat catgtcaacc cctgcagttc ttgaagctat aactttaacc ccagcatctt
    10801 ttaaagtttc ataaatataa ggattatcta tatagttagt ttgttgtata gatataccat
    10861 catacccttt agctttaact acattttctt cagtcatgtt ttcaggataa atatccactt
    10921 gaacatcctt atgttcttca gaccattttt ttattactgg ttcttcataa tcgcgtgctc
    10981 caaatactag tattttcata tcaataccct cctgtaatta ttaaattatt atggtaattt
    11041 ttcatttaga aataatatgt agcatataag gttatatttt ttatacaaaa tttttaaggt
    11101 taaaaattta gttttgaaat tgttttccct gtgttatttt gatatttagt aattttttat
    11161 ttaatgtaat aattactcta aaatttatca aagaaattgt tattttttag attaaatatt
    11221 attaaaaaat tatctaagtt tgaaattagt taactaactt gctgattaat tacaatgata
    11281 acatgtgttt ttgagtttag caatgaaaac tttttttgaa atgtcaagct ttttcataaa
    11341 aaaatatata aaaaaaactt ttataagcat agaaagaata gcaaaatgca atggatagtg
    11401 gcaagatgcc acgatatgaa aaagattatt caattgcata ttgttaaaaa acattcaaat
    11461 caagcgatat tttgattaaa tataaagttg gcacgataaa tgcttaacaa tataggtgta
    11521 agacaataaa acaataaaaa ataattttaa taatttttaa gttattttag ataagattag
    11581 gaactttgac atcagacagt taatatcaga aaaaagtatt ttatgagtga tttaatcgaa
    11641 attttataat tgatactatt aaggaggaaa acgttatgct tttagaagga gttaaagtag
    11701 tagaactttc aagtttcatc gcagcaccat gttgtgcaaa aatgttaggt gactggggtg
    11761 cagaggttat taagattgaa cctatagaag gtgatggaat aagagttatg ggtggaacat
    11821 ttaaatctcc agcatcagat gatgaaaacc ctatgtttga attagaaaat ggaaataaaa
    11881 agggtgtaag tattaatgta aaatcaaaag aaggagtaga aatattacat aaattattat
    11941 cagaagcaga catatttgta actaatgtta gagttcaagc attagaaaaa atgggtatag
    12001 cttatgacca aataaaagat aagtatccag gattaatatt ctctcaaata ttaggatatg
    12061 gtgaaaaagg acctttaaaa gataaaccag gatttgacta tactgcatac ttcgcaagag
    12121 gaggagttag ccaatctgtt atggaaaaag gaacatctcc agcaaataca gcagcaggat
    12181 ttggtgacca ctatgcaggt ctagcactag cagcaggaag tttagcagca ttacataaaa
    12241 aagctcaaac tggtaaaggt gagagagtaa cagtaagtct tttccataca gctatatatg
    12301 gaatgggaac aatgataaca acagcacaat acggaaatga aatgccttta tcaagagaaa
    12361 atccaaacag cccattaatg actacatata aatgtaaaga tggaagatgg attcaattag
    12421 ctttaataca atacaacaag tggttaggca aattctgtaa ggttataaat agagaatata
    12481 tattagaaga tgatagatat aataacatag attcaatggt taatcatgtt gaagatttag
    12541 ttaagatagt tggagaagct atgttagaaa aaacattaga cgagtggtca gctttattag
    12601 aagaagcaga cttaccattt gaaaaaattc aaagctgtga agatttatta gatgacgaac
    12661 aagcttgggc aaatgacttc ttatttaaga aaacatacga tagcggaaat acaggtgtct
    12721 tagttaatac tccagttatg tttagaaatg aaggaattaa agaatataca ccagcaccaa
    12781 aagtaggtca acatactgta gaagtattaa aatctttagg ctacgatgaa gagaaaataa
    12841 ataactttaa agatagtaaa gttgtaagat attaattagt aattctagat tttttaaaag
    12901 gagaatgcta aagatgtaca caatgggatt agatataggt tcaactgcat caaagggagt
    12961 aatcttaaag aatggggaag atattgtagc ttctgaaaca atatcctctg gtactgggac
    13021 tactggacca tcaagagttt tagaaaaatt atatggcaag acaggtcttg caagagaaga
    13081 tattaaaaaa gttgtagtta caggatatgg aagaatgaac tattcagatg ctgataagca
    13141 aataagtgaa ttaagctgtc atgctagagg ggtaaatttc ataattccag agacaagaac
    13201 cattattgac ataggtggtc aagatgcaaa ggtattaaaa ttagataata atggaagact
    13261 attaaacttt cttatgaatg acaaatgtgc tgcaggtaca ggaagatttt tagatgtaat
    13321 ggcaaaaata atagaggttg atgtatctga actcggaagt atatctatga attctcaaaa
    13381 tgaagtatca ataagcagta catgtacagt atttgcagag tctgaggtta tatcacattt
    13441 atctgaaaat gcaaaaattg aagatatagt ggcaggtatt catacttcag tagcaaagag
    13501 agtttctagc ctagtaaaaa gaataggagt acaaagaaat gtagttatgg ttggtggagt
    13561 tgctagaaat agtggtattg taagagctat ggcaagagaa atcaacacag aaattattgt
    13621 acctgatata cctcaattaa ctggtgcttt aggagcagcg ttatatgctt ttgatgaagc
    13681 aaaagaatca caaaaagaag tgaaaaatat ataaaaagag ggatgaaaat gtctgaaaaa
    13741 aaagaagcta gagtagtaat taatgattta ttagctgaac aatatgcaaa tgcatttaaa
    13801 gctaaagaag aaggaagacc tgtaggttgg tcaacatcag tatttcctca agagttagca
    13861 gaagtatttg acttaaacgt attatatcca gaaaaccaag cagctggagt agcagctaaa
    13921 aaaggttctt tagaattatg tgaaatagct gaatctaaag gatattctat tgacctatgt
    13981 gcatatgcaa gaacaaattt tggtctttta gaaaatggtg gatgtgaagc tttggatatg
    14041 ccagctccag atttcctact ttgctgtaac aatatatgta atcaagttat aaaatggtat
    14101 gaaaatattt caagagaatt agatatacct ttaataatga ttgatacaac tttcaataat
    14161 gaagacgaag ttactcaatc aagaatagat tatattaaag ctcaatttga agaagctata
    14221 aaacaactag aaattatatc aggaaagaaa tttgacccta agaagtttga agaagtaatg
    14281 aaaatatcag ctgaaaacgg aagactatgg aagtattcta tgagtttacc agcagattct
    14341 tctccttctc caatgaatgg atttgactta tttacttaca tggctgtaat agtttgtgct
    14401 agaggtaaaa aagaaactac agaagcattt aagttactta tagaagaatt agaagacaac
    14461 atgaaaactg gtaaatcttc tttcagaggg gaagaaaaat acagaataat gatggaaggt
    14521 ataccttgtt ggccatatat aggatacaag atgaaaacat tagctaaatt tggagttaac
    14581 atgacaggta gtgtttaccc acatgcttgg gcattacaat atgaagttaa tgatttagat
    14641 ggaatggcag tagcatatag tactatgttt aacaatgtaa acctagaccg tatgacaaaa
    14701 tatagagttg attctttagt agagggtaaa tgtgatggag cattctatca tatgaacaga
    14761 agctgtaaac ttatgagttt aatacaatat gaaatgcaaa gaagagcagc tgaagaaact
    14821 ggattaccat atgctggatt tgatggtgac caagcagacc ctagagcttt cactaatgct
    14881 caatttgaaa caagaattca aggtttagtt gaagtaatgg aagaaagaaa aaaacttaat
    14941 agaggtgaga tataatggaa gctattttat ctaaaatgaa agaagtagtt gaaaatccaa
    15001 atgcggctgt aaaaaaatat aaaaatgaaa ctggtaaaaa agctataggt tgtttcccag
    15061 tttattgccc agaagaaatt atacatgcag ctggaatgct tccagttggt atatggggag
    15121 gacaaacaga attagattta gctaaacaat atttccctgc atttgcatgt tcaataatgc
    15181 aatcatgttt agaatatgga ttaaaaggtg cttatgatga attatctgga gttattatac
    15241 caggtatgtg tgatacacta atttgtttag gacaaaactg gaaatcagca gtacctcata
    15301 taaaatatat atcattagta cacccacaaa atagaaaact tgaagctggt gtaaaatact
    15361 taatcagtga gtacaaaggt gtaaaaagag aacttgaaga aatttgtgga tatgaaatag
    15421 aagaagcaaa aattcatgaa agtatagaag tttacaatga acatagaaaa actatgagag
    15481 actttgttga agtagcttat aaacattcta atactataaa accatcaata agaagcttag
    15541 taattaaaag tgggttcttt atgagaaaag aagaacatac tgagctagtg aaagatttaa
    15601 tagcaaaatt aaatgctatg ccagaagaag tctgttctgg aaaaaaagtt ttattaacag
    15661 gtatattagc tgattctaaa gatatattag acattttaga agacaacaat atatcagttg
    15721 tagctgacga cttagcacaa gaaacaagac aattcagaac agatgtacca gcaggtgatg
    15781 atgcgttaga gagattagca agacaatggt caaacataga aggatgttca ttagcttatg
    15841 accctaagaa aaaacgtggg tcacttatag tagatgaagt taaaaagaaa gatatagatg
    15901 gtgttatctt ctgtatgatg aaattctgtg acccagaaga atacgattat cctttagtta
    15961 gaaaagatat agaagatagt ggaataccta ctttatatgt tgaaatcgac caacaaactc
    16021 agaataatga acaagccaga actcgtattc aaacttttgc tgagatgatg agtttagcgt
    16081 aagttcatta aaataaattt actataaaat atgaaaattg gaggaagcta tgttatataa
    16141 caaagaacaa gaacttttaa gaaaagcagt aagagatttt gttagtaaag aattagatac
    16201 tttaccagca gaaatggata aaacaggtgt aatgcctaag gaattaatca aaaaattagc
    16261 tgatgcaaaa tttataagca gtaatatccc agaagaatat ggtggtgggg gagcaggata
    16321 tgtttcttac gctatagtaa tggaagaaat agctagaaga tgtgcttcaa cagctacttt
    16381 tgttacagct ggttcttctc ttgcttcatt accaatactt tacaatggta ctgaagagca
    16441 aaaacaaaaa tacttaaaag gtatagcaac aggtgaatta ataggagcat ttgggttaac
    16501 tgagccagga gctggttctg atgcaggtgg acaacaaaca acagcagaat tagttggaga
    16561 ccactatata ttaaatggta gaaaaacttt cataactaat ggaccattct gtgatgtagc
    16621 tatagtaata gcagttacag atagaagtaa aggacttaga ggaacatcag cgtttatagt
    16681 agaaagtaaa tgggatggtt tctcaacagg agctcatgaa gataagatgg gtataagagg
    16741 aactgaaact tctgacttaa tatttgaaaa cgttaaagtt ccaaaagaaa acttacttgg
    16801 aaaagaaggt caaggattta agatagcaat gggtactcta gaagttggta gaataggtgt
    16861 tgctgcctta gctctaggaa tagctcaagg tgctttagat gaagctgtta aatatacaaa
    16921 acaaagagtt caatttggta agcctatagc taaattccaa aatactcaat ttactatagc
    16981 tgacatggaa acaaaagttt gtgcagctag aggattagtt tatgatgcag cacaaaagag
    17041 agatgcagga atgagagttg ctcaagaatc tgctatggct aaatactatg catcagaaat
    17101 tgcaaatgaa gttgcttata aagcattaca acttcacggt ggatatggat ttataaaaga
    17161 ttatgaaatc gaaagaatgt acagagatgc tagaatcgta tcaatatacg aaggaacatc
    17221 agaagttcaa aaaatggtaa tttcatcaaa cgtattaaaa taataaataa tctaatgaaa
    17281 ttggaggtat agactttgaa aatattagtt tgcgtaaaac aagttccaga tactaacgaa
    17341 gtaagaataa ataaagaaac aggtactctt ataagagatg gagttccaag tatattaaac
    17401 ccagatgatg caaatgcatt agaggaagct ttaaaaatta aagatgagca tgatgatgta
    17461 actataacag ttataacaat gggacctcct caagcagact ttatgctaag agagtgttta
    17521 gctatgggtg ctgatgatgc aatattatta agtgatagag catttggagg agctgatact
    17581 tgggctacat caaatactat tgcagcggga atatctaaag taggtgacta tgacataata
    17641 tttgcaggaa gacaagcaat agatggagat actgcacaag ttggaccaca aattgcagag
    17701 aaattagaca ttcctcaagt tacatatgta caagatttca aaatagaagg aaaagatata
    17761 atagttcaaa gacaattaga agatggatac gaattaataa aagtaagtac acctgtactt
    17821 ttaacagcag taaaagagtt aaatacacct agatacatgt ctgttgataa aatagtaaaa
    17881 gcatataaac atgatgtaaa agtttggaca attgatgatt tagatgtaaa taaagaagaa
    17941 gttggtttaa aagcatcacc aactaaagta tttagatcat ttactcctga accaagagga
    18001 aaaggagaaa tcttagaagg taaagctgat gaaatagcta gtaaaataat aatcggtcta
    18061 aaacaaaagc acattatata agttggagga gtacaaacta tgaatgatat aaaagattta
    18121 agttcttata aaaacgtatg gatatttgca gaacaaagag aaggaaaaat agctccagta
    18181 gttatagaat tattaggaga aggaagaaaa ttagctaaag aagtagatgc agaactttgt
    18241 gcaatattat taggaaaaga tgttgatgga ttagctaaag aattaatcac ttttggagct
    18301 gacaaagttt atgttgcaga tgatgctctt ttagaaaaat atacaactga tgcatataca
    18361 aaagtaataa aagatgcaat agatgaaata aaaccagaaa taatgctttt cggagcaact
    18421 catataggta gagacttagc acctagaata gcttcaagag ttggaactgg attaacagct
    18481 gactgtacta agttagaaat agacccagaa gataagaaaa taaaacaaac tcgtccagca
    18541 tttggtggaa acataatggc tacaatcatt tgtccaaacc atagacctca aatgtctaca
    18601 gttagacctg gtgttatgga taaagctgaa aaagacgaaa caagaactgg tgaagttata
    18661 gcattagact acaaaataac tcaagatgat ataagaacta ctgttttaga aacagttaaa
    18721 actaagaaag atttagtatc tcttacagat gcaaatgtta tagtatcagg tggtttagga
    18781 ttaggtggac cagaaggatt tgaaatgctt aagaaattag ctgacaaatt aggtggagta
    18841 gttggttctt ctcgtgcggc tgttgatgct ggatggatag accattctca ccaagtaggt
    18901 caaacaggaa ctactgttaa accaaaccta tatatagctt gtggtatatc aggagcaata
    18961 caacatttag caggtatgca atcatcagat ttcataattg ctataaacaa aaacccagca
    19021 gctccaattt tagaaatcgc tgactatgga gtagttggag acttacatga aatagttcca
    19081 atgcttatag aaaaattaga tagcgttgat gatttattag aagctataaa agcttaatag
    19141 atacaaacta tataaatatt actgattgaa taagtcttat tagttagtaa cataattatt
    19201 aaccctttga taagttattg ctagtgtgta tttgtcagtt attaaaaagt ctgtttgaat
    19261 aaaattttat aatacaagat aatctggata atccttatat gtatattgct tacaaattgt
    19321 gagttatatt ctgtaaggat tatctttgtt tttttaaata aatcttaaat ttaattaaat
    19381 tgtattaaat agacaaataa ttactaaata tgtgataaaa tacaattaaa agcaaaatga
    19441 aatttttaac aaactataat cattaaaatt atatcttagt tacgttttaa tgaaataaac
    19501 tacttgaaaa gacgaatatt ataaggagtt gattatatgt gctgatggta tttattgtaa
    19561 gcaaacaata aattttgtat gtagttcaat aaattactta atgaaaggtg cgaatattaa
    19621 tggataataa tttaataggg cttatagaac atgtagaaaa tccagccatt ttatgtaaag
    19681 aatcaggcga aataatatac tgtaatcatc taatagatag tatttttagt tttctagata
    19741 taaaaaagcc tagaaatata aatgaattag attcaaattt tgacaaaaca gaaatactga
    19801 cagatagtaa aaagaaaata gctttcagag agttaaggat gactgcacat atatacaata
    19861 tgaaagataa taataatgaa aataatatag tttatttatt tgagaagtct ctaatatctg
    19921 ataaagtaat tgaagatata atagagcata tagatgaagt tgttgttgtg tttaacaaag
    19981 atggggtaat tgaaaagatg aacactgtca gtgatgagat attacctttt aaaagaactg
    20041 aggtacttgg tagaaatata acagaccttg tgagacaagg attagttgaa gaaccaataa
    20101 tattaaacat gcttaaagtg aagaaaaaga tttatagaaa tatcgtttac ccagatggga
    20161 agcttattgc atatacggca gttccaagat gggattctaa gggaaagctt acaggaggag
    20221 tactaacagg gagagatatt tcaagggtta ttaagcttga atctcagata aaatatagtg
    20281 atatatcaga agacacagag tatataagtc aaagtaagat tatggacaat ataaaaaaag
    20341 ttgttaagag agctgcagcc tcagattctt ctatatttat aaatggagaa tcaggtgtag
    20401 gaaaagaaat aatagcaaga acaatatata agtatagttc aaggagagac aaacctttta
    20461 tagctataaa ctgtggagct ataccaaatg aattattaga gtcagagttt tttggatatg
    20521 aagaaggttc ttttactgga gctaagaaaa aaggtaaaaa gggacttttt gaagaggcga
    20581 atggtggaac tattttcttg gatgagatag gtgagttacc aatgcagatg caaaaaaaat
    20641 tacttagggt tatacaagaa aatactatta ctagaatagg tggtagtaag cctataaaaa
    20701 tagatgttag atatataagt gctactaata tttctcatga agaccttaga aataacctta
    20761 aatttagaca agatttgtac tatagattaa gtgttattcc agtaaaaata cctcctctta
    20821 gagaaagaaa agaggatata gtaccattag taaattattt cttaaaactt tacaatgaaa
    20881 agtacaatag agaagtagaa gtttcaccta aagttattga gttattagaa gaatattctt
    20941 ggccaggaaa cataagagaa ttaaaaaaca tcattgaaag atttgtagta ttatcagcta
    21001 aaaatgtaat tggagaagat gaatttaaca tgctgataaa tttagatatg attgataatg
    21061 aaacagatga tttatcacca atagtggtaa atggaattat gaatcttaat gatgcatata
    21121 aaatagtgga ccaaataatg ataagtaagg ctataaataa gtatggttca ataacaaagg
    21181 ctgctgaagt tataggtata tatccttcta ccatccatag aaagataaag agtggacata
    21241 ttcacgttta gctgtcagtt taaaaagaca atataattaa aatattataa gatacataat
    21301 tgatacaact taaaagagat ggcttaaaaa taaatttaat tactttaagt catctctttt
    21361 cttttataaa tatttaaaag ttatattagt ttatagagtt agcagaacct aaaacatcat
    21421 ctatcttgct ttcaactaca gcttgtatag catctctacc agcaccaatg tattttcttg
    21481 ggtcaaattc ttttggattt tcagctaaga attttctgat agcagcagtc atagctagtc
    21541 ttaagtcagt atccatgttt attttacaaa cagccataga agatgctttt cttaacatat
    21601 ctacaggtac acctttagca ccagctatat ttccaccaaa ttcattacat gtagcaacag
    21661 cgttttggtc aacagcagat gcaccatgaa gaactattgg gaaacctggt aatttgcttt
    21721 ggatttcttc tagtatatca aatcttaatt tagcttctcc tttgaatttg aaagcaccat
    21781 gagaagttcc aatagctatt gctaatgaat caacacctgt tctttcaacg aactcaactg
    21841 cctcagctgg ttgagtatac ttgtgaacat cagaagtaac atcatcttct gttccagcta
    21901 gaacaccaag ttctgcttca acaacaacac ctttagagtg tgcatattca acagcttctt
    21961 tagttattct aacattttct tcaaagtcaa aatgagaacc atctatcata actgaagaga
    22021 aaccagcatc aatacaagtt ttaatagcat ccatatttgg accatggtct aagtgaagag
    22081 ctacatctac acctatttca tcagaagcag ccttaaccat ttcaactaat gtatgaggtc
    22141 cagcatattt aacagctgac atagaagctt gtatcataac ataagaattt ttagctttag
    22201 cagcttttaa aacaccttgt aattgttcta agtcacttat gttaaatgca cctatagcaa
    22261 atccaccttc gtaagctttt ttaaacattt cttttgtagt aattaatgcc attttaaact
    22321 cctcctatta acttttaaaa tttacccatc acttatatta taacgttaaa tcaaaaaaag
    22381 tatatagtaa attgtaataa ctataaatta caagtataat gttaaataga agacaatagg
    22441 attaaataaa ataataaaga atataaataa tttaggaaaa ttagctatat aatgctaact
    22501 ataagggtag gaactacctt attagtttgg agatactgat aacaatagtt gtcttgacca
    22561 agaagttacc acttcaaacg ttatcgaagg gaattaagtg gatgataatt cactaaaaat
    22621 ttaaaataaa ggagataaac tatgccacag ataaaaataa gaggaattaa tgaaaatgat
    22681 atatgtaaaa taagtaaaaa aatgataaat gatttagttg aagctgtaaa atgtccaaga
    22741 gactactttg aaatagaatg tataaagtca gttgcaataa gagatggtaa aatagcagat
    22801 gtatatcctt ttgttgaagt agcttggttt gatagaggac aagaagtaca agatatagta
    22861 gcaagaataa taactgatag tataagaaat aatttagatg tagaaagtat ggatttagca
    22921 tttacagtat ttgaaaaaga aaaatattat gagaatggag agcattttta atggctaaaa
    22981 agcaacgtat agataaaatt ctttcaaatt taggttatgg aagtagaagt gaaataaaga
    23041 agtattgtaa acaagggtct gtagtagtaa atggaagtga agtttcaaat ccaggaactc
    23101 aagtagacac tgaaaatgat gagatattat ttaatggaga agaagttata tatagagaat
    23161 atatatattt gattaaaaaa tagctacgta cactcgtgac tttagtcatg agttagtagc
    23221 taaaatagtc agcatatagg gaaacttata tgtagagata ggatagagcc tatccaatac
    23281 tacttgaatt gctggaaacc cctaaagcta accaaactaa aacataagga tgaaataaac
    23341 ctaagtgtga aagttacgaa agtagaaaaa attggttaga tggtataagg ttaaacccta
    23401 agtactttaa aatgggcaat cagcaggtaa gctccgaata ggagaaactt caacgactat
    23461 tcctcttgag ggaagtacac tacaagctat cggtagtgga agtgggtaga ccttagcgga
    23521 taatgccgaa ggataagata tagtctgtgc ttgcatgaaa gtgtaagaag ttcataagag
    23581 aactgcatag gtagtagcga acttatgtga acgacaacct caaaaatgat aaaagttaag
    23641 acttacggtt cttaaatatg ttatttaaaa ttaaatataa aaccttctaa ataattgttt
    23701 taaataatta catttgttaa cattattata ggtgattaat aaattgttca ccacagcatt
    23761 atataatata ttaaatatga taaaatcatt aaaaagtgta tcaaaaaaca attaaagtga
    23821 ggtgatagca gtggaaaaag cttataagtt tagaatgtat ccaaataaaa aacaacaaga
    23881 gttaattaac aaaacttttg gatgttgtag atttgtatat aataagtatc ttgctaaaag
    23941 aatagaagtt tataaaaacg ataaagaaac ttttacttat aaacagtgta gttctgattt
    24001 gactaattta aaaaaagaat taaaatggct taaggaacct gacaaatttt cactacaaaa
    24061 cgccttaaaa gatttagata atgcatataa aaaattcttt aaagaaaaag caggatttcc
    24121 taaatttaaa tcaaagaaaa ttaatagatt ttcatataaa actaacttta caaatggaaa
    24181 cattatgtat tgtggtcaac atataaaact acctaaactt ggtatggtta agataaggga
    24241 taaacaagta cctaaaggga gaatacttaa tgccactata tctaaagaac caagtggtag
    24301 atattatgta tcattatgct gtactgatgt agatattgaa gtatttgaaa atactaataa
    24361 tcagataggt ttagatttag gaattaaaga attttgtatc tcaagttgtg gagaatttat
    24421 agaaaatcct aagtatctta agaagtcatt aaacaagctt gctaaattac aaagagaatt
    24481 atcgagaaag acaatcggta gtttaaatag aaataaagca agattaaaag ttgcaagact
    24541 tcaagaacat atagctaatc aaagaaatga ttttctacaa aaactatcta ctaaattaat
    24601 aaaagagaat gatattattt gcatagaaga tttacaagta aagaatatga ttaggaattg
    24661 taaactatct cgcttaattt ctgatgtgtc atggtcagag tttattcgcc aattagaata
    24721 caaggctaat tggcatggta gacaaattgt aaaggtaggt aaattctttg caagttcaca
    24781 aatatgcaat aaatgtgggt ataaaaacga ggaagtgaaa gacttaagta taagagaatg
    24841 gatttgtcct agttgtaatg aaactcacga tagagatata aatgcaagta taaatatatt
    24901 aaaagaagga ttaagactaa taacaactca aaataaataa cttatgtaag aaccgtagga
    24961 actacgggga tagcctgtgg agaattagta agacatattt tagtatgcaa aattctgtga
    25021 agcaggaacc ctgtgacttt agtcatggga ggttcaggat gaataaacct gatggatata
    25081 tatcagcaac tacagataaa tatgacccaa cagtattaga tttaattgat ttatcatact
    25141 tagcttttga accatttcct gttggaaggt tagataaaga cacagaggga ttattagttt
    25201 taactaatga tggaaagctt tctcatagag ttttatctcc taagaagcat gtgcctaaga
    25261 cttattatgc aaaaattgat ggagtagtta ctgaagaaga tgtagaagct tttttagaag
    25321 gtgtagtgct tgatgacgga tataaaacta tgccatcaca gttaaatata ttaaaaagtg
    25381 atgatgaatc agaaatagag cttacaatac atgaaggtaa gtttcaccaa gtaaaaagaa
    25441 tgtttgaaag cgtaggcaaa aaagtagtat acttaaaaag attgtctatg ggcaatttaa
    25501 aattggatga aagtttagag ttaggtgagt atagagagtt aacagatgaa gaagtaaaat
    25561 tgattgaaga aagataataa agatactata gtaaattgga ggaatgtctg tgaagaaaaa
    25621 agatgttata gaatttgaag tagataaaat ggaatttggt ggtacatctt taagtcaagt
    25681 tggagataga gttatccata tgaagggtgg aataagtggt caaaaggtga gagctggagt
    25741 taaaaaagtt agaagtaaga aagctgaagt taagatgata gaattattag agaactcacc
    25801 acttgaaact gaagaaactt gcaagcactt tagagagtgt ggaggatgta cactattgtc
    25861 tgtgccatat gaaaaacaat tagaaataaa agaaaaacaa gttatggatt tatttttaaa
    25921 gcaagattta tttggatttc agtttttagg gatagaagga agtccagaaa acaaatatta
    25981 tagaaataag atggaatata cttttggaga tgaagtaaaa aatggacctt tgacattagg
    26041 tcttcataaa aaaggaaagc atatagatat acaaactgtt gaggagtgta tgttggttga
    26101 tgaagacttc tcaaagatat tagtttctag tgtagagttt ttcaatgaaa aaaagcttcc
    26161 ttattataga acaatgaatc acaaaggata tttgagacat cttgtagtta gaaaagggat
    26221 tcatactaat gagattatgg ttaatatagt aacttcttct caagaagatt ttgatatgaa
    26281 tgagtttaaa gatatgcttt tagggattga tttaaaggct gagttagtag gtgtacttca
    26341 tactattaat gatggtttag cagatgcagt ccaatgtgat gagttaagag tattgtatgg
    26401 aagagattat atacaagaag aaattttagg tcttaagttt aagatttcac cattttcgtt
    26461 tttccaaacc aatactaagg gagctgaggt tctttatagt attgctaggg attttattgg
    26521 agattacaat gataaggttg tatttgactt gtatagtggt actgggtcta ttggacaggt
    26581 tatggctggt gctgctaaga aagtgtatgg tattgagata gttgaggaag ctgttgttgc
    26641 tgctaatgag aatgctaagt tgaatggact tactaattgt gagtttattg ctggggatgt
    26701 ggctaaggtt gttaaggatt taaaggacaa gcctgatttg attattgttg accctcctag
    26761 accaggcatt cataaggatg ctattaggga tatttgtgga tttggtgcta aggagattgt
    26821 ttatatttct tgtaatccta agtctttggt tgttgatttg gttgatttta aggggtatgg
    26881 ttatgagatt aagatggtta agtgtatgga tatgttccca aatacgccac attgtgagac
    26941 tgtagttaaa cttattagag aataacaggg tttcagactt ttatattgtg tcttaaaagt
    27001 agatttgcca cctatttgcc accataatta tttttgggtg gcaaatttat tctacaatga
    27061 tttcaaaaat atttaccatc tggtttctca tgttattagt tacatgtaaa tatgtatcca
    27121 tagttgttga agttttagca tgtccgagta tatgctggat atcttttata ttagtaccat
    27181 tttctaataa catagtatca gggtttttaa aataaagtgt gtattcttct agagtagtga
    27241 taattaaaat atcaaatatc actatacaaa ggaaagtgca ccctttttat gtttagcaaa
    27301 aacgaaatat taaaaaaact tattgaagaa tatgatgtca aaacaactac agatattcaa
    27361 gatatgctaa aagatttatt tacaaataca attcatcaaa tatttccatt gtcgaatttt
    27421 aacggtttaa acataatata ttgactgata taataaaatc atagaatatt ttagggggaa
    27481 atagattatg tttaagaaaa agttaatagc tgttgcaatg agtataacta tgattagtgt
    27541 agggagcttt tcgtatgctc attcaggaag aactgattca tcaggaggtc atcgtgataa
    27601 taaaaataaa tctggattag gaagttatca ctatcattgt ggtggttatc cagcccattt
    27661 acataataat ggtggttgtc cttatactgg aggaggaagc agttctggaa caacaacttc
    27721 ggttaataat gaagaaaagc aaaagaggtc tgttggagaa aaaggatata atcaagggta
    27781 tgaagatggg tataaaggaa attatagttc atcaaattat agtggagatt atagtgatac
    27841 atatgaatca aagtactcag aaggatatga aaaaggtaag gctaaattag aagaggaaga
    27901 aaaggtggct aaagagactg gatataattt agggcttaca ggtgctaaat ctaataatac
    27961 atatgaaaaa gaagttttaa aaaatgctta tgataccgga tattcaactg gatacaatga
    28021 atataagact aaaaagatag aagaatataa agctaaaggg atagaggata gcaataaaga
    28081 taaagaaaaa atgacatttg aagaaaacat agattctgaa tttatagatg cttataataa
    28141 tgcttatgac gaaatacaag aacaattaaa aaatgattac actactcaag gatttgagag
    28201 tgctatcaaa ggagaaagat ttgacacatc aactataggt aatgttaaat atgctaattg
    28261 gtttaaagaa ggatatgata atggtaaggt taagttacct aaagcaaaag aaagtgtata
    28321 taatcaaggt tacaatgaag aagattttag tataccatat gaaatgaagt ctattgaaac
    28381 taagttaaaa ggtgtatatg atgaaggttt agaaaaaaga gaagaagaga aaagtagaaa
    28441 tgctacttat ggggttggag ctggaacagc agctgtagtt gctggagtag tatataaaaa
    28501 taaaaaacgt aaaaagatat agatgctaga tataccaatg atgacaagtg tataacaaat
    28561 ataattttaa gtataaatat ttaaaatata gaagggaagg ttatatctat gggatttaac
    28621 tttaggaaaa gcataaatct aggaggagga ctcaaattaa atttaggtaa gaagagtgta
    28681 ggtataagtg ctggtgttaa aggtgctaga gtgtcagtta attcaaaagg aagaaaatca
    28741 gctacattga gtatacctgg aactggaata tcatatacaa aaactagtac aaagaaacgt
    28801 aaacctaaat aaatatttga tatactaaga aatagactgt tacaaatagt ctatttttta
    28861 gtatatagat ttaaaaagtg acaaaatttt gaaatataaa ctaatttcat aaaggaaaat
    28921 attcttttat gtagaattat aatatttaag taatattata aaatttatag gaggatttca
    28981 ttatgaaatt aagcaaaaca ctattggcaa tagggatgtc tgtttcatta ttgattgcta
    29041 gttgtccaac atcaaacgct cttagttcta ttaattcaat aaaaggtaca aataagtatg
    29101 aaacagcagg tttaatagca gataaacaaa attatga
//
